Flip and Flop Variants of AMPA Receptors in the Rat Lumbar Spinal Cord
Tölle, T. R. ; Berthele, A. ; Zieglgänsberger, W. ; Seeburg, P. H. ; Wisden, W.
Oxford, UK : Blackwell Publishing Ltd
Published 1995
Oxford, UK : Blackwell Publishing Ltd
Published 1995
| ISSN: |
1460-9568
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| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
The expression of eight messenger RNA splice forms encoding the Flip and Flop variants of AMPA receptor subunits GluR-A to -D in the rat lumbar spinal cord was examined by in situ hybridization using specific oligonucleotides. In the dorsal horn (laminae I, II and III) the predominant mRNA was GluR-B Flip. Much lower levels of GluR-A Flip were found in lamina I and in superficial parts of lamina II outer. In the ventral horn, motor neurons expressed mainly GluR-B Flip, GluR-C Flip and Flop, and GluR-D Flip. Serial sectioning through large motor neurons indicated that a given cell contained, for example, both GluR-C Flip and Flop splice types.
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| Type of Medium: |
Electronic Resource
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| URL: |