An immunohistochemical study of copper, zinc-containing superoxide dismutase detected by a monoclonal antibody in gastric mucosa and gastric cancer
OKA, S. ; OGINO, K. ; HOUBARA, T. ; YOSHIMURA, S. ; OKAZAKI, Y. ; TAKEMOTO, T. ; KATO, N. ; IIDA, Y. ; UDA, T.
Oxford, UK : Blackwell Publishing Ltd
Published 1990
Oxford, UK : Blackwell Publishing Ltd
Published 1990
| ISSN: |
1365-2559
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| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
The immunohistochemical localization of copper, zinc-superoxide dismutase (Cu, Zn-SOD) in human gastric mucosa and gastric cancer was studied using a monoclonal antibody. In gastric mucosa, parietal cells, pyloric glandular cells and foci of intestinal metaplasia showed positive staining in the cytoplasm and/or nucleus. The wide distribution of Cu, Zn-SOD in the gastric mucosa suggests cell function may be vulnerable to active oxygen species. In gastric cancer, 34 of 70 cases showed a positive reaction for Cu, Zn-SOD. There was a relationship between the grade of Cu, Zn-SOD immunoreactivity and the histological type of gastric cancer, well-differentiated types of gastric cancer being more frequently positive. The positive cases of poorly-differentiated adenocarcinoma were characterized by a pattern of diffusely infiltrative invasion. These results suggest that some types of gastric cancer are resistant to active oxygen species.
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| Type of Medium: |
Electronic Resource
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| URL: |