GENETIC STUDIES OF LOW-ABUNDANCE HUMAN PLASMA PROTEINS: VII. HETEROGENEITY OF THE C1, SUBCOMPONENT OF THE FIRST COMPLEMENT COMPONENT

1744-313X

Blackwell Publishing Journal Backfiles 1879-2005

Biology

Medicine

Charge-based structural variation has been observed in the C1, subcomponent of the first complement component C1 after isoelectric focusing and immunoblot-ting. One common and two uncommon autosomal co-dominantly expressed alleles, designated ClS*1, ClS*2 and ClS*3, have been recognized at the ClS structural locus. The frequency of these alleles was 0·979, 0·016 and 0·005, respectively, in a U.S. white population. No variation at the ClS locus was observed in a U.S. black sample (n = 95).

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