GENE DELETION AND GENE DUPLICATION WITHIN THE CLUSTER OF HUMAN HEAVY-CHAIN GENES: SELECTIVE ABSENCE OF IgG SUB-CLASSES
Loghem, Erna van ; Sukernik, R. I. ; Osipova, L. P. ; Zegers, B. J. M. ; Matsumoto, H. ; Lange and, Gerda de ; Lefrance, G.
Oxford, UK : Blackwell Publishing Ltd
Published 1980
Oxford, UK : Blackwell Publishing Ltd
Published 1980
| ISSN: |
1744-313X
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|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
|
| Topics: |
Biology
Medicine
|
| Notes: |
Individuals with selective absence of IgG1 and IgG2 were discovered by testing for allotypes and isotypes of the respective sub-classes. These individuals were homozygous for sub-class deleted Gm-Am haplotypes, as shown by allotype studies in two families (Gm-;…;g;A2ml/Gm-;n;b;A2ml and Gm-;n;b;A2ml/Gm-;…;b;A2ml) and by a population study of New Guineans (Gm fa;-;b;A2m2). The individuals with IgGl sub-class deficiency showed elevation of IgG2, IgG4 and in particular of IgG3.Gene deletion can result from unequal crossing over which renders a complementary chromosome with a duplication of a sub-class gene. In one family, duplication of γ3 genes was observed to have happened in one of a twin pair. Quantitation of sub-classes in families with γ1- and with γ3-duplicated haplotypes did not show increased levels of the gene involved.
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| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798290383260614656 |
|---|---|
| autor | Loghem, Erna van Sukernik, R. I. Osipova, L. P. Zegers, B. J. M. Matsumoto, H. Lange and, Gerda de Lefrance, G. |
| autorsonst | Zegers, B. J. M. Matsumoto, H. Lange and, Gerda de Lefrance, G. |
| book_url | http://dx.doi.org/10.1111/j.1744-313X.1980.tb00722.x |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLZ239398432 |
| insertion_date | 2012-04-26 |
| issn | 1744-313X |
| journal_name | International journal of immunogenetics |
| materialart | 1 |
| notes | Individuals with selective absence of IgG1 and IgG2 were discovered by testing for allotypes and isotypes of the respective sub-classes. These individuals were homozygous for sub-class deleted Gm-Am haplotypes, as shown by allotype studies in two families (Gm-;…;g;A2ml/Gm-;n;b;A2ml and Gm-;n;b;A2ml/Gm-;…;b;A2ml) and by a population study of New Guineans (Gm fa;-;b;A2m2). The individuals with IgGl sub-class deficiency showed elevation of IgG2, IgG4 and in particular of IgG3.Gene deletion can result from unequal crossing over which renders a complementary chromosome with a duplication of a sub-class gene. In one family, duplication of γ3 genes was observed to have happened in one of a twin pair. Quantitation of sub-classes in families with γ1- and with γ3-duplicated haplotypes did not show increased levels of the gene involved. |
| package_name | Blackwell Publishing |
| publikationsjahr_anzeige | 1980 |
| publikationsjahr_facette | 1980 |
| publikationsjahr_intervall | 8019:1980-1984 |
| publikationsjahr_sort | 1980 |
| publikationsort | Oxford, UK |
| publisher | Blackwell Publishing Ltd |
| reference | 7 (1980), S. 0 |
| search_space | articles |
| shingle_author_1 | Loghem, Erna van Sukernik, R. I. Osipova, L. P. Zegers, B. J. M. Matsumoto, H. Lange and, Gerda de Lefrance, G. |
| shingle_author_2 | Loghem, Erna van Sukernik, R. I. Osipova, L. P. Zegers, B. J. M. Matsumoto, H. Lange and, Gerda de Lefrance, G. |
| shingle_author_3 | Loghem, Erna van Sukernik, R. I. Osipova, L. P. Zegers, B. J. M. Matsumoto, H. Lange and, Gerda de Lefrance, G. |
| shingle_author_4 | Loghem, Erna van Sukernik, R. I. Osipova, L. P. Zegers, B. J. M. Matsumoto, H. Lange and, Gerda de Lefrance, G. |
| shingle_catch_all_1 | Loghem, Erna van Sukernik, R. I. Osipova, L. P. Zegers, B. J. M. Matsumoto, H. Lange and, Gerda de Lefrance, G. GENE DELETION AND GENE DUPLICATION WITHIN THE CLUSTER OF HUMAN HEAVY-CHAIN GENES: SELECTIVE ABSENCE OF IgG SUB-CLASSES Blackwell Publishing Ltd Individuals with selective absence of IgG1 and IgG2 were discovered by testing for allotypes and isotypes of the respective sub-classes. These individuals were homozygous for sub-class deleted Gm-Am haplotypes, as shown by allotype studies in two families (Gm-;…;g;A2ml/Gm-;n;b;A2ml and Gm-;n;b;A2ml/Gm-;…;b;A2ml) and by a population study of New Guineans (Gm fa;-;b;A2m2). The individuals with IgGl sub-class deficiency showed elevation of IgG2, IgG4 and in particular of IgG3.Gene deletion can result from unequal crossing over which renders a complementary chromosome with a duplication of a sub-class gene. In one family, duplication of γ3 genes was observed to have happened in one of a twin pair. Quantitation of sub-classes in families with γ1- and with γ3-duplicated haplotypes did not show increased levels of the gene involved. 1744-313X 1744313X |
| shingle_catch_all_2 | Loghem, Erna van Sukernik, R. I. Osipova, L. P. Zegers, B. J. M. Matsumoto, H. Lange and, Gerda de Lefrance, G. GENE DELETION AND GENE DUPLICATION WITHIN THE CLUSTER OF HUMAN HEAVY-CHAIN GENES: SELECTIVE ABSENCE OF IgG SUB-CLASSES Blackwell Publishing Ltd Individuals with selective absence of IgG1 and IgG2 were discovered by testing for allotypes and isotypes of the respective sub-classes. These individuals were homozygous for sub-class deleted Gm-Am haplotypes, as shown by allotype studies in two families (Gm-;…;g;A2ml/Gm-;n;b;A2ml and Gm-;n;b;A2ml/Gm-;…;b;A2ml) and by a population study of New Guineans (Gm fa;-;b;A2m2). The individuals with IgGl sub-class deficiency showed elevation of IgG2, IgG4 and in particular of IgG3.Gene deletion can result from unequal crossing over which renders a complementary chromosome with a duplication of a sub-class gene. In one family, duplication of γ3 genes was observed to have happened in one of a twin pair. Quantitation of sub-classes in families with γ1- and with γ3-duplicated haplotypes did not show increased levels of the gene involved. 1744-313X 1744313X |
| shingle_catch_all_3 | Loghem, Erna van Sukernik, R. I. Osipova, L. P. Zegers, B. J. M. Matsumoto, H. Lange and, Gerda de Lefrance, G. GENE DELETION AND GENE DUPLICATION WITHIN THE CLUSTER OF HUMAN HEAVY-CHAIN GENES: SELECTIVE ABSENCE OF IgG SUB-CLASSES Blackwell Publishing Ltd Individuals with selective absence of IgG1 and IgG2 were discovered by testing for allotypes and isotypes of the respective sub-classes. These individuals were homozygous for sub-class deleted Gm-Am haplotypes, as shown by allotype studies in two families (Gm-;…;g;A2ml/Gm-;n;b;A2ml and Gm-;n;b;A2ml/Gm-;…;b;A2ml) and by a population study of New Guineans (Gm fa;-;b;A2m2). The individuals with IgGl sub-class deficiency showed elevation of IgG2, IgG4 and in particular of IgG3.Gene deletion can result from unequal crossing over which renders a complementary chromosome with a duplication of a sub-class gene. In one family, duplication of γ3 genes was observed to have happened in one of a twin pair. Quantitation of sub-classes in families with γ1- and with γ3-duplicated haplotypes did not show increased levels of the gene involved. 1744-313X 1744313X |
| shingle_catch_all_4 | Loghem, Erna van Sukernik, R. I. Osipova, L. P. Zegers, B. J. M. Matsumoto, H. Lange and, Gerda de Lefrance, G. GENE DELETION AND GENE DUPLICATION WITHIN THE CLUSTER OF HUMAN HEAVY-CHAIN GENES: SELECTIVE ABSENCE OF IgG SUB-CLASSES Blackwell Publishing Ltd Individuals with selective absence of IgG1 and IgG2 were discovered by testing for allotypes and isotypes of the respective sub-classes. These individuals were homozygous for sub-class deleted Gm-Am haplotypes, as shown by allotype studies in two families (Gm-;…;g;A2ml/Gm-;n;b;A2ml and Gm-;n;b;A2ml/Gm-;…;b;A2ml) and by a population study of New Guineans (Gm fa;-;b;A2m2). The individuals with IgGl sub-class deficiency showed elevation of IgG2, IgG4 and in particular of IgG3.Gene deletion can result from unequal crossing over which renders a complementary chromosome with a duplication of a sub-class gene. In one family, duplication of γ3 genes was observed to have happened in one of a twin pair. Quantitation of sub-classes in families with γ1- and with γ3-duplicated haplotypes did not show increased levels of the gene involved. 1744-313X 1744313X |
| shingle_title_1 | GENE DELETION AND GENE DUPLICATION WITHIN THE CLUSTER OF HUMAN HEAVY-CHAIN GENES: SELECTIVE ABSENCE OF IgG SUB-CLASSES |
| shingle_title_2 | GENE DELETION AND GENE DUPLICATION WITHIN THE CLUSTER OF HUMAN HEAVY-CHAIN GENES: SELECTIVE ABSENCE OF IgG SUB-CLASSES |
| shingle_title_3 | GENE DELETION AND GENE DUPLICATION WITHIN THE CLUSTER OF HUMAN HEAVY-CHAIN GENES: SELECTIVE ABSENCE OF IgG SUB-CLASSES |
| shingle_title_4 | GENE DELETION AND GENE DUPLICATION WITHIN THE CLUSTER OF HUMAN HEAVY-CHAIN GENES: SELECTIVE ABSENCE OF IgG SUB-CLASSES |
| sigel_instance_filter | dkfz geomar wilbert ipn albert |
| source_archive | Blackwell Publishing Journal Backfiles 1879-2005 |
| timestamp | 2024-05-06T08:15:51.619Z |
| titel | GENE DELETION AND GENE DUPLICATION WITHIN THE CLUSTER OF HUMAN HEAVY-CHAIN GENES: SELECTIVE ABSENCE OF IgG SUB-CLASSES |
| titel_suche | GENE DELETION AND GENE DUPLICATION WITHIN THE CLUSTER OF HUMAN HEAVY-CHAIN GENES: SELECTIVE ABSENCE OF IgG SUB-CLASSES |
| topic | W WW-YZ |
| uid | nat_lic_papers_NLZ239398432 |