HETEROLOGOUS TUMOUR GROWTH PATTERNS INDUCED IN RELATED MHC - DEFINED CHICKEN LINES BY SEPARATE ISOLATES OF AN AVIAN SARCOMA VIRUS STRAIN
Cutting, J. A. ; Watanabe, D. H. ; Strebel, F. R. ; Vogt, P. K. ; McBride, R. A.
Oxford, UK : Blackwell Publishing Ltd
Published 1981
Oxford, UK : Blackwell Publishing Ltd
Published 1981
| ISSN: |
1744-313X
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|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Biology
Medicine
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| Notes: |
Different patterns of tumour growth resulted from inoculation of separate isolates of the Subgroup C Bratislava 77 strain (B77) of Avian Sarcoma Virus (ASV) into three closely-related inbred lines of chickens. The major genetic difference between these chicken lines is that each is homozygous for a different MHC haplotype. Since for one of the viral isolates, resistance to progressive tumour growth has been shown to be controlled by MHC-linked genes, the data presented here suggest that MHC-controlled tumour rejection operates on viral or cellular determinants different from those which define classical viral group or subgroup specificity.
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| Type of Medium: |
Electronic Resource
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| URL: |