ANALYSIS OF UNEXPECTED INHIBITIONS OF T LYMPHOCYTE PROLIFERATION TO SOLUBLE ANTIGEN, ALLOANTIGEN AND MITOGEN BY UNFRAGMENTED ANTI-I-Ak OR ANTI-I-E/Ck MONOCLONAL ANTIBODIES
Dubreuil, P. C. ; Caillol, Danielle H. ; Lemonnier, F. A.
Oxford, UK : Blackwell Publishing Ltd
Published 1982
Oxford, UK : Blackwell Publishing Ltd
Published 1982
| ISSN: |
1744-313X
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|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Biology
Medicine
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| Notes: |
We investigated the capacity of anti-I-Ak and anti-I-E/Ck monoclonal antibodies (m.Ab.) to inhibit T lymphocyte proliferative responses to soluble antigen (Keyhole limpet hemocyanin), alloantigens (H-2 or non-H-2 related) and a mitogen (Concanavalin A). Surprisingly, specific inhibition was observed in all circumstances, and with both anti-I-Ak and anti-I-E/Ck m.Ab., whether the responses tested were I restricted in cell mixing experiments or not.The significance of the inhibition by anti-Ia m.Ab. of non-Ia-restricted responses is still not completely understood. These results, however, strongly suggest that in vitro inhibition by anti-Ia antibodies of T cell proliferative responses does not necessarily indicate I restriction of the presentation to T lymphocytes of the corresponding antigen.
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| Type of Medium: |
Electronic Resource
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| URL: |