Circulating levels of IgG1 and IgG4 Anti-IgE antibodies and asthma severity
Shakib, F. ; Sihoe, J. ; Smith, S. J. ; Wilding, P. ; Clark, M. M. ; Knox, A.
Oxford, UK : Blackwell Publishing Ltd
Published 1994
Oxford, UK : Blackwell Publishing Ltd
Published 1994
| ISSN: |
1398-9995
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|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
In this paper, we have determined the levels of IgG1 and IgG4 anti-IgE in the sera of 66 asthma patients suffering from mild (n= 24), moderate (n= 23), or severe (n= 19) symptoms, and 20 nonatopic, healthy subjects. The study has revealed that although asthma patients have significantly elevated levels of IgG1 and IgG4 anti-IgE antibodies, the concentration of these autoantibodies is not related to the severity of asthma. This conclusion may be related to the known heterogeneity of autoanti-IgE antibodies in terms of their ability to trigger basophil histamine release.
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| Type of Medium: |
Electronic Resource
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| URL: |