Psoriasis: a defect in the regulation of epidermal proteases, as shown by serial biopsies after cantharidin application
DUBERTRET, L. ; BERTAUX, B. ; FOSSE, M. ; TOURAINE, R.
Oxford, UK : Blackwell Publishing Ltd
Published 1984
Oxford, UK : Blackwell Publishing Ltd
Published 1984
| ISSN: |
1365-2133
|
|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
|
| Topics: |
Medicine
|
| Notes: |
The possible role of epidermal serine proteases in the genesis of psoriatic lesions was investigated by sequential biopsies of the epidermal damage induced by topical cantharidin. In the skin of normal subjects, epidermal damage was followed by the transient appearance of proteolytic activity in the upper epidermis accompanied by temporary hyperacanthosis and perivascular inflammatory cells in the superficial dermis. In the uninvolved skin of five patients with psoriasis this proteolysis persisted longer, for more than 7 days. Thereafter, in three of the patients, the proteolysis abated, and this was followed by disappearance of the hyperacanthosis and the dermal infiltrate; in the other two psoriatics the proteolysis and hyperacanthosis increased, and a typical Koebner phenomenon ensued. Migration of neutrophils into the epidermis occurred as a later event. Thus the abnormal persistence of proteolytic activity in the upper epidermis after cantharidin application distinguishes the normal from the psoriatic skin injury response and might initiate the psoriatic lesion.
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798290089814523905 |
|---|---|
| autor | DUBERTRET, L. BERTAUX, B. FOSSE, M. TOURAINE, R. |
| autorsonst | TOURAINE, R. |
| book_url | http://dx.doi.org/10.1111/j.1365-2133.1984.tb04654.x |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLZ239032551 |
| insertion_date | 2012-04-17 |
| issn | 1365-2133 |
| journal_name | British journal of dermatology |
| materialart | 1 |
| notes | The possible role of epidermal serine proteases in the genesis of psoriatic lesions was investigated by sequential biopsies of the epidermal damage induced by topical cantharidin. In the skin of normal subjects, epidermal damage was followed by the transient appearance of proteolytic activity in the upper epidermis accompanied by temporary hyperacanthosis and perivascular inflammatory cells in the superficial dermis. In the uninvolved skin of five patients with psoriasis this proteolysis persisted longer, for more than 7 days. Thereafter, in three of the patients, the proteolysis abated, and this was followed by disappearance of the hyperacanthosis and the dermal infiltrate; in the other two psoriatics the proteolysis and hyperacanthosis increased, and a typical Koebner phenomenon ensued. Migration of neutrophils into the epidermis occurred as a later event. Thus the abnormal persistence of proteolytic activity in the upper epidermis after cantharidin application distinguishes the normal from the psoriatic skin injury response and might initiate the psoriatic lesion. |
| package_name | Blackwell Publishing |
| publikationsjahr_anzeige | 1984 |
| publikationsjahr_facette | 1984 |
| publikationsjahr_intervall | 8019:1980-1984 |
| publikationsjahr_sort | 1984 |
| publikationsort | Oxford, UK |
| publisher | Blackwell Publishing Ltd |
| reference | 110 (1984), S. 0 |
| search_space | articles |
| shingle_author_1 | DUBERTRET, L. BERTAUX, B. FOSSE, M. TOURAINE, R. |
| shingle_author_2 | DUBERTRET, L. BERTAUX, B. FOSSE, M. TOURAINE, R. |
| shingle_author_3 | DUBERTRET, L. BERTAUX, B. FOSSE, M. TOURAINE, R. |
| shingle_author_4 | DUBERTRET, L. BERTAUX, B. FOSSE, M. TOURAINE, R. |
| shingle_catch_all_1 | DUBERTRET, L. BERTAUX, B. FOSSE, M. TOURAINE, R. Psoriasis: a defect in the regulation of epidermal proteases, as shown by serial biopsies after cantharidin application Blackwell Publishing Ltd The possible role of epidermal serine proteases in the genesis of psoriatic lesions was investigated by sequential biopsies of the epidermal damage induced by topical cantharidin. In the skin of normal subjects, epidermal damage was followed by the transient appearance of proteolytic activity in the upper epidermis accompanied by temporary hyperacanthosis and perivascular inflammatory cells in the superficial dermis. In the uninvolved skin of five patients with psoriasis this proteolysis persisted longer, for more than 7 days. Thereafter, in three of the patients, the proteolysis abated, and this was followed by disappearance of the hyperacanthosis and the dermal infiltrate; in the other two psoriatics the proteolysis and hyperacanthosis increased, and a typical Koebner phenomenon ensued. Migration of neutrophils into the epidermis occurred as a later event. Thus the abnormal persistence of proteolytic activity in the upper epidermis after cantharidin application distinguishes the normal from the psoriatic skin injury response and might initiate the psoriatic lesion. 1365-2133 13652133 |
| shingle_catch_all_2 | DUBERTRET, L. BERTAUX, B. FOSSE, M. TOURAINE, R. Psoriasis: a defect in the regulation of epidermal proteases, as shown by serial biopsies after cantharidin application Blackwell Publishing Ltd The possible role of epidermal serine proteases in the genesis of psoriatic lesions was investigated by sequential biopsies of the epidermal damage induced by topical cantharidin. In the skin of normal subjects, epidermal damage was followed by the transient appearance of proteolytic activity in the upper epidermis accompanied by temporary hyperacanthosis and perivascular inflammatory cells in the superficial dermis. In the uninvolved skin of five patients with psoriasis this proteolysis persisted longer, for more than 7 days. Thereafter, in three of the patients, the proteolysis abated, and this was followed by disappearance of the hyperacanthosis and the dermal infiltrate; in the other two psoriatics the proteolysis and hyperacanthosis increased, and a typical Koebner phenomenon ensued. Migration of neutrophils into the epidermis occurred as a later event. Thus the abnormal persistence of proteolytic activity in the upper epidermis after cantharidin application distinguishes the normal from the psoriatic skin injury response and might initiate the psoriatic lesion. 1365-2133 13652133 |
| shingle_catch_all_3 | DUBERTRET, L. BERTAUX, B. FOSSE, M. TOURAINE, R. Psoriasis: a defect in the regulation of epidermal proteases, as shown by serial biopsies after cantharidin application Blackwell Publishing Ltd The possible role of epidermal serine proteases in the genesis of psoriatic lesions was investigated by sequential biopsies of the epidermal damage induced by topical cantharidin. In the skin of normal subjects, epidermal damage was followed by the transient appearance of proteolytic activity in the upper epidermis accompanied by temporary hyperacanthosis and perivascular inflammatory cells in the superficial dermis. In the uninvolved skin of five patients with psoriasis this proteolysis persisted longer, for more than 7 days. Thereafter, in three of the patients, the proteolysis abated, and this was followed by disappearance of the hyperacanthosis and the dermal infiltrate; in the other two psoriatics the proteolysis and hyperacanthosis increased, and a typical Koebner phenomenon ensued. Migration of neutrophils into the epidermis occurred as a later event. Thus the abnormal persistence of proteolytic activity in the upper epidermis after cantharidin application distinguishes the normal from the psoriatic skin injury response and might initiate the psoriatic lesion. 1365-2133 13652133 |
| shingle_catch_all_4 | DUBERTRET, L. BERTAUX, B. FOSSE, M. TOURAINE, R. Psoriasis: a defect in the regulation of epidermal proteases, as shown by serial biopsies after cantharidin application Blackwell Publishing Ltd The possible role of epidermal serine proteases in the genesis of psoriatic lesions was investigated by sequential biopsies of the epidermal damage induced by topical cantharidin. In the skin of normal subjects, epidermal damage was followed by the transient appearance of proteolytic activity in the upper epidermis accompanied by temporary hyperacanthosis and perivascular inflammatory cells in the superficial dermis. In the uninvolved skin of five patients with psoriasis this proteolysis persisted longer, for more than 7 days. Thereafter, in three of the patients, the proteolysis abated, and this was followed by disappearance of the hyperacanthosis and the dermal infiltrate; in the other two psoriatics the proteolysis and hyperacanthosis increased, and a typical Koebner phenomenon ensued. Migration of neutrophils into the epidermis occurred as a later event. Thus the abnormal persistence of proteolytic activity in the upper epidermis after cantharidin application distinguishes the normal from the psoriatic skin injury response and might initiate the psoriatic lesion. 1365-2133 13652133 |
| shingle_title_1 | Psoriasis: a defect in the regulation of epidermal proteases, as shown by serial biopsies after cantharidin application |
| shingle_title_2 | Psoriasis: a defect in the regulation of epidermal proteases, as shown by serial biopsies after cantharidin application |
| shingle_title_3 | Psoriasis: a defect in the regulation of epidermal proteases, as shown by serial biopsies after cantharidin application |
| shingle_title_4 | Psoriasis: a defect in the regulation of epidermal proteases, as shown by serial biopsies after cantharidin application |
| sigel_instance_filter | dkfz geomar wilbert ipn albert |
| source_archive | Blackwell Publishing Journal Backfiles 1879-2005 |
| timestamp | 2024-05-06T08:11:11.991Z |
| titel | Psoriasis: a defect in the regulation of epidermal proteases, as shown by serial biopsies after cantharidin application |
| titel_suche | Psoriasis: a defect in the regulation of epidermal proteases, as shown by serial biopsies after cantharidin application |
| topic | WW-YZ |
| uid | nat_lic_papers_NLZ239032551 |