Increased thickness of pregnancy-associated melanoma

TRAVERS, R.L. ; SOBER, A.J. ; BERWICK, M. ; MIHM, M.C. ; HARNHILL, R.L. ; DUNCAN, L. M.

Oxford, UK : Blackwell Publishing Ltd
Published 1995
ISSN:
1365-2133
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Summary The effects of pregnancy on the pathophysiology of melanoma remain unclear. Although a gender-specific advantage for women vs. men is seen for characteristics such as stage at presentation, site of primary tumour, and survival time, an adverse effect of pregnancy on melanoma development and progression has been reported.In a retrospective study, we investigated the tumour characteristics of women who developed pregnancy-associated melanoma, and compared them with melanomas arising in non-pregnant women of child-bearing age. The patient records of the Massachusetts General Hospital Pigmented Lesion Clinic were reviewed, and 465 women of reproductive age (16–45 years) who developed melanoma were identified. Of these, in 45 women (age 21–42 years) there was a close temporal relationship between diagnosis of the tumour and pregnancy. Clinical and histological characteristics of the primary tumours were recorded. Differences in tumour thickness, site and histological type were analysed.The mean thickness of pregnancy-associated melanomas was significantly greater than that of non-pregnancy-associated tumours (2.28 vs. 1.22 mm, respectively: P 〈 0.007). No differences in histological type (P = 0.64) or site (P = 0.74) of the primary tumours were found between the two patient groups. Not surprisingly, multivariate analysis revealed that tumour thickness was a statistically significant variable in determining prognosis (P = 0001). An unexpected finding, on multivariate analysis, was a possible pregnancy-associated prognostic advantage (P = 008).Melanomas arising during pregnancy are thicker, but are not necessarily associated with a less favourable prognosis than tumours arising in non-pregnant women of child-bearing age. The mechanisms by which pregnancy may lead to increased thickness of melanoma have yet to be elucidated, and merit further study.
Type of Medium:
Electronic Resource
URL:
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autor TRAVERS, R.L.
SOBER, A.J.
BERWICK, M.
MIHM, M.C.
HARNHILL, R.L.
DUNCAN, L. M.
autorsonst MIHM, M.C.
HARNHILL, R.L.
DUNCAN, L. M.
book_url http://dx.doi.org/10.1111/j.1365-2133.1995.tb16942.x
datenlieferant nat_lic_papers
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insertion_date 2012-04-17
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journal_name British journal of dermatology
materialart 1
notes Summary The effects of pregnancy on the pathophysiology of melanoma remain unclear. Although a gender-specific advantage for women vs. men is seen for characteristics such as stage at presentation, site of primary tumour, and survival time, an adverse effect of pregnancy on melanoma development and progression has been reported.In a retrospective study, we investigated the tumour characteristics of women who developed pregnancy-associated melanoma, and compared them with melanomas arising in non-pregnant women of child-bearing age. The patient records of the Massachusetts General Hospital Pigmented Lesion Clinic were reviewed, and 465 women of reproductive age (16–45 years) who developed melanoma were identified. Of these, in 45 women (age 21–42 years) there was a close temporal relationship between diagnosis of the tumour and pregnancy. Clinical and histological characteristics of the primary tumours were recorded. Differences in tumour thickness, site and histological type were analysed.The mean thickness of pregnancy-associated melanomas was significantly greater than that of non-pregnancy-associated tumours (2.28 vs. 1.22 mm, respectively: P 〈 0.007). No differences in histological type (P = 0.64) or site (P = 0.74) of the primary tumours were found between the two patient groups. Not surprisingly, multivariate analysis revealed that tumour thickness was a statistically significant variable in determining prognosis (P = 0001). An unexpected finding, on multivariate analysis, was a possible pregnancy-associated prognostic advantage (P = 008).Melanomas arising during pregnancy are thicker, but are not necessarily associated with a less favourable prognosis than tumours arising in non-pregnant women of child-bearing age. The mechanisms by which pregnancy may lead to increased thickness of melanoma have yet to be elucidated, and merit further study.
package_name Blackwell Publishing
publikationsjahr_anzeige 1995
publikationsjahr_facette 1995
publikationsjahr_intervall 8004:1995-1999
publikationsjahr_sort 1995
publikationsort Oxford, UK
publisher Blackwell Publishing Ltd
reference 132 (1995), S. 0
search_space articles
shingle_author_1 TRAVERS, R.L.
SOBER, A.J.
BERWICK, M.
MIHM, M.C.
HARNHILL, R.L.
DUNCAN, L. M.
shingle_author_2 TRAVERS, R.L.
SOBER, A.J.
BERWICK, M.
MIHM, M.C.
HARNHILL, R.L.
DUNCAN, L. M.
shingle_author_3 TRAVERS, R.L.
SOBER, A.J.
BERWICK, M.
MIHM, M.C.
HARNHILL, R.L.
DUNCAN, L. M.
shingle_author_4 TRAVERS, R.L.
SOBER, A.J.
BERWICK, M.
MIHM, M.C.
HARNHILL, R.L.
DUNCAN, L. M.
shingle_catch_all_1 TRAVERS, R.L.
SOBER, A.J.
BERWICK, M.
MIHM, M.C.
HARNHILL, R.L.
DUNCAN, L. M.
Increased thickness of pregnancy-associated melanoma
Blackwell Publishing Ltd
Summary The effects of pregnancy on the pathophysiology of melanoma remain unclear. Although a gender-specific advantage for women vs. men is seen for characteristics such as stage at presentation, site of primary tumour, and survival time, an adverse effect of pregnancy on melanoma development and progression has been reported.In a retrospective study, we investigated the tumour characteristics of women who developed pregnancy-associated melanoma, and compared them with melanomas arising in non-pregnant women of child-bearing age. The patient records of the Massachusetts General Hospital Pigmented Lesion Clinic were reviewed, and 465 women of reproductive age (16–45 years) who developed melanoma were identified. Of these, in 45 women (age 21–42 years) there was a close temporal relationship between diagnosis of the tumour and pregnancy. Clinical and histological characteristics of the primary tumours were recorded. Differences in tumour thickness, site and histological type were analysed.The mean thickness of pregnancy-associated melanomas was significantly greater than that of non-pregnancy-associated tumours (2.28 vs. 1.22 mm, respectively: P 〈 0.007). No differences in histological type (P = 0.64) or site (P = 0.74) of the primary tumours were found between the two patient groups. Not surprisingly, multivariate analysis revealed that tumour thickness was a statistically significant variable in determining prognosis (P = 0001). An unexpected finding, on multivariate analysis, was a possible pregnancy-associated prognostic advantage (P = 008).Melanomas arising during pregnancy are thicker, but are not necessarily associated with a less favourable prognosis than tumours arising in non-pregnant women of child-bearing age. The mechanisms by which pregnancy may lead to increased thickness of melanoma have yet to be elucidated, and merit further study.
1365-2133
13652133
shingle_catch_all_2 TRAVERS, R.L.
SOBER, A.J.
BERWICK, M.
MIHM, M.C.
HARNHILL, R.L.
DUNCAN, L. M.
Increased thickness of pregnancy-associated melanoma
Blackwell Publishing Ltd
Summary The effects of pregnancy on the pathophysiology of melanoma remain unclear. Although a gender-specific advantage for women vs. men is seen for characteristics such as stage at presentation, site of primary tumour, and survival time, an adverse effect of pregnancy on melanoma development and progression has been reported.In a retrospective study, we investigated the tumour characteristics of women who developed pregnancy-associated melanoma, and compared them with melanomas arising in non-pregnant women of child-bearing age. The patient records of the Massachusetts General Hospital Pigmented Lesion Clinic were reviewed, and 465 women of reproductive age (16–45 years) who developed melanoma were identified. Of these, in 45 women (age 21–42 years) there was a close temporal relationship between diagnosis of the tumour and pregnancy. Clinical and histological characteristics of the primary tumours were recorded. Differences in tumour thickness, site and histological type were analysed.The mean thickness of pregnancy-associated melanomas was significantly greater than that of non-pregnancy-associated tumours (2.28 vs. 1.22 mm, respectively: P 〈 0.007). No differences in histological type (P = 0.64) or site (P = 0.74) of the primary tumours were found between the two patient groups. Not surprisingly, multivariate analysis revealed that tumour thickness was a statistically significant variable in determining prognosis (P = 0001). An unexpected finding, on multivariate analysis, was a possible pregnancy-associated prognostic advantage (P = 008).Melanomas arising during pregnancy are thicker, but are not necessarily associated with a less favourable prognosis than tumours arising in non-pregnant women of child-bearing age. The mechanisms by which pregnancy may lead to increased thickness of melanoma have yet to be elucidated, and merit further study.
1365-2133
13652133
shingle_catch_all_3 TRAVERS, R.L.
SOBER, A.J.
BERWICK, M.
MIHM, M.C.
HARNHILL, R.L.
DUNCAN, L. M.
Increased thickness of pregnancy-associated melanoma
Blackwell Publishing Ltd
Summary The effects of pregnancy on the pathophysiology of melanoma remain unclear. Although a gender-specific advantage for women vs. men is seen for characteristics such as stage at presentation, site of primary tumour, and survival time, an adverse effect of pregnancy on melanoma development and progression has been reported.In a retrospective study, we investigated the tumour characteristics of women who developed pregnancy-associated melanoma, and compared them with melanomas arising in non-pregnant women of child-bearing age. The patient records of the Massachusetts General Hospital Pigmented Lesion Clinic were reviewed, and 465 women of reproductive age (16–45 years) who developed melanoma were identified. Of these, in 45 women (age 21–42 years) there was a close temporal relationship between diagnosis of the tumour and pregnancy. Clinical and histological characteristics of the primary tumours were recorded. Differences in tumour thickness, site and histological type were analysed.The mean thickness of pregnancy-associated melanomas was significantly greater than that of non-pregnancy-associated tumours (2.28 vs. 1.22 mm, respectively: P 〈 0.007). No differences in histological type (P = 0.64) or site (P = 0.74) of the primary tumours were found between the two patient groups. Not surprisingly, multivariate analysis revealed that tumour thickness was a statistically significant variable in determining prognosis (P = 0001). An unexpected finding, on multivariate analysis, was a possible pregnancy-associated prognostic advantage (P = 008).Melanomas arising during pregnancy are thicker, but are not necessarily associated with a less favourable prognosis than tumours arising in non-pregnant women of child-bearing age. The mechanisms by which pregnancy may lead to increased thickness of melanoma have yet to be elucidated, and merit further study.
1365-2133
13652133
shingle_catch_all_4 TRAVERS, R.L.
SOBER, A.J.
BERWICK, M.
MIHM, M.C.
HARNHILL, R.L.
DUNCAN, L. M.
Increased thickness of pregnancy-associated melanoma
Blackwell Publishing Ltd
Summary The effects of pregnancy on the pathophysiology of melanoma remain unclear. Although a gender-specific advantage for women vs. men is seen for characteristics such as stage at presentation, site of primary tumour, and survival time, an adverse effect of pregnancy on melanoma development and progression has been reported.In a retrospective study, we investigated the tumour characteristics of women who developed pregnancy-associated melanoma, and compared them with melanomas arising in non-pregnant women of child-bearing age. The patient records of the Massachusetts General Hospital Pigmented Lesion Clinic were reviewed, and 465 women of reproductive age (16–45 years) who developed melanoma were identified. Of these, in 45 women (age 21–42 years) there was a close temporal relationship between diagnosis of the tumour and pregnancy. Clinical and histological characteristics of the primary tumours were recorded. Differences in tumour thickness, site and histological type were analysed.The mean thickness of pregnancy-associated melanomas was significantly greater than that of non-pregnancy-associated tumours (2.28 vs. 1.22 mm, respectively: P 〈 0.007). No differences in histological type (P = 0.64) or site (P = 0.74) of the primary tumours were found between the two patient groups. Not surprisingly, multivariate analysis revealed that tumour thickness was a statistically significant variable in determining prognosis (P = 0001). An unexpected finding, on multivariate analysis, was a possible pregnancy-associated prognostic advantage (P = 008).Melanomas arising during pregnancy are thicker, but are not necessarily associated with a less favourable prognosis than tumours arising in non-pregnant women of child-bearing age. The mechanisms by which pregnancy may lead to increased thickness of melanoma have yet to be elucidated, and merit further study.
1365-2133
13652133
shingle_title_1 Increased thickness of pregnancy-associated melanoma
shingle_title_2 Increased thickness of pregnancy-associated melanoma
shingle_title_3 Increased thickness of pregnancy-associated melanoma
shingle_title_4 Increased thickness of pregnancy-associated melanoma
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timestamp 2024-05-06T08:11:06.657Z
titel Increased thickness of pregnancy-associated melanoma
titel_suche Increased thickness of pregnancy-associated melanoma
topic WW-YZ
uid nat_lic_papers_NLZ238984923