Graft-versus-host reaction affecting lesional skin but not normal skin in a patient with piebaldism
| ISSN: |
1365-2133
|
|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
|
| Topics: |
Medicine
|
| Notes: |
Summary A case of graft-vs.-host disease (GVHD) arising solely within an area affected by piebaldism is described. The patient, a 35-year-old woman with a single hypopigmented patch on the right leg present since birth, had received an allogeneic bone marrow transplant (BMT) from an HLA-identical sibling donor, for treatment of a myelodysplastic syndrome (MDS). Beginning on day + 38 post-BMT, the patch developed changes which were histologically consistent with GVHD. Syngeneic mixed epidermal cell-lymphocyte reaction (MECLR) testing of tissue from the patch, and from adjacent normal skin, showed differences which suggest that piebaldism-affected skin is immunologically different from normal skin. These findings may offer new insight into the pathophysiology of this disorder.
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798290084249731073 |
|---|---|
| autor | CHOW, R. K. P. STEWART, W. D. HO, V. C. |
| book_url | http://dx.doi.org/10.1046/j.1365-2133.1996.d01-760.x |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLZ238982092 |
| insertion_date | 2012-04-17 |
| issn | 1365-2133 |
| journal_name | British journal of dermatology |
| materialart | 1 |
| notes | Summary A case of graft-vs.-host disease (GVHD) arising solely within an area affected by piebaldism is described. The patient, a 35-year-old woman with a single hypopigmented patch on the right leg present since birth, had received an allogeneic bone marrow transplant (BMT) from an HLA-identical sibling donor, for treatment of a myelodysplastic syndrome (MDS). Beginning on day + 38 post-BMT, the patch developed changes which were histologically consistent with GVHD. Syngeneic mixed epidermal cell-lymphocyte reaction (MECLR) testing of tissue from the patch, and from adjacent normal skin, showed differences which suggest that piebaldism-affected skin is immunologically different from normal skin. These findings may offer new insight into the pathophysiology of this disorder. |
| package_name | Blackwell Publishing |
| publikationsjahr_anzeige | 1996 |
| publikationsjahr_facette | 1996 |
| publikationsjahr_intervall | 8004:1995-1999 |
| publikationsjahr_sort | 1996 |
| publikationsort | Oxford, UK |
| publisher | Blackwell Publishing Ltd |
| reference | 134 (1996), S. 0 |
| search_space | articles |
| shingle_author_1 | CHOW, R. K. P. STEWART, W. D. HO, V. C. |
| shingle_author_2 | CHOW, R. K. P. STEWART, W. D. HO, V. C. |
| shingle_author_3 | CHOW, R. K. P. STEWART, W. D. HO, V. C. |
| shingle_author_4 | CHOW, R. K. P. STEWART, W. D. HO, V. C. |
| shingle_catch_all_1 | CHOW, R. K. P. STEWART, W. D. HO, V. C. Graft-versus-host reaction affecting lesional skin but not normal skin in a patient with piebaldism Blackwell Publishing Ltd Summary A case of graft-vs.-host disease (GVHD) arising solely within an area affected by piebaldism is described. The patient, a 35-year-old woman with a single hypopigmented patch on the right leg present since birth, had received an allogeneic bone marrow transplant (BMT) from an HLA-identical sibling donor, for treatment of a myelodysplastic syndrome (MDS). Beginning on day + 38 post-BMT, the patch developed changes which were histologically consistent with GVHD. Syngeneic mixed epidermal cell-lymphocyte reaction (MECLR) testing of tissue from the patch, and from adjacent normal skin, showed differences which suggest that piebaldism-affected skin is immunologically different from normal skin. These findings may offer new insight into the pathophysiology of this disorder. 1365-2133 13652133 |
| shingle_catch_all_2 | CHOW, R. K. P. STEWART, W. D. HO, V. C. Graft-versus-host reaction affecting lesional skin but not normal skin in a patient with piebaldism Blackwell Publishing Ltd Summary A case of graft-vs.-host disease (GVHD) arising solely within an area affected by piebaldism is described. The patient, a 35-year-old woman with a single hypopigmented patch on the right leg present since birth, had received an allogeneic bone marrow transplant (BMT) from an HLA-identical sibling donor, for treatment of a myelodysplastic syndrome (MDS). Beginning on day + 38 post-BMT, the patch developed changes which were histologically consistent with GVHD. Syngeneic mixed epidermal cell-lymphocyte reaction (MECLR) testing of tissue from the patch, and from adjacent normal skin, showed differences which suggest that piebaldism-affected skin is immunologically different from normal skin. These findings may offer new insight into the pathophysiology of this disorder. 1365-2133 13652133 |
| shingle_catch_all_3 | CHOW, R. K. P. STEWART, W. D. HO, V. C. Graft-versus-host reaction affecting lesional skin but not normal skin in a patient with piebaldism Blackwell Publishing Ltd Summary A case of graft-vs.-host disease (GVHD) arising solely within an area affected by piebaldism is described. The patient, a 35-year-old woman with a single hypopigmented patch on the right leg present since birth, had received an allogeneic bone marrow transplant (BMT) from an HLA-identical sibling donor, for treatment of a myelodysplastic syndrome (MDS). Beginning on day + 38 post-BMT, the patch developed changes which were histologically consistent with GVHD. Syngeneic mixed epidermal cell-lymphocyte reaction (MECLR) testing of tissue from the patch, and from adjacent normal skin, showed differences which suggest that piebaldism-affected skin is immunologically different from normal skin. These findings may offer new insight into the pathophysiology of this disorder. 1365-2133 13652133 |
| shingle_catch_all_4 | CHOW, R. K. P. STEWART, W. D. HO, V. C. Graft-versus-host reaction affecting lesional skin but not normal skin in a patient with piebaldism Blackwell Publishing Ltd Summary A case of graft-vs.-host disease (GVHD) arising solely within an area affected by piebaldism is described. The patient, a 35-year-old woman with a single hypopigmented patch on the right leg present since birth, had received an allogeneic bone marrow transplant (BMT) from an HLA-identical sibling donor, for treatment of a myelodysplastic syndrome (MDS). Beginning on day + 38 post-BMT, the patch developed changes which were histologically consistent with GVHD. Syngeneic mixed epidermal cell-lymphocyte reaction (MECLR) testing of tissue from the patch, and from adjacent normal skin, showed differences which suggest that piebaldism-affected skin is immunologically different from normal skin. These findings may offer new insight into the pathophysiology of this disorder. 1365-2133 13652133 |
| shingle_title_1 | Graft-versus-host reaction affecting lesional skin but not normal skin in a patient with piebaldism |
| shingle_title_2 | Graft-versus-host reaction affecting lesional skin but not normal skin in a patient with piebaldism |
| shingle_title_3 | Graft-versus-host reaction affecting lesional skin but not normal skin in a patient with piebaldism |
| shingle_title_4 | Graft-versus-host reaction affecting lesional skin but not normal skin in a patient with piebaldism |
| sigel_instance_filter | dkfz geomar wilbert ipn albert |
| source_archive | Blackwell Publishing Journal Backfiles 1879-2005 |
| timestamp | 2024-05-06T08:11:06.657Z |
| titel | Graft-versus-host reaction affecting lesional skin but not normal skin in a patient with piebaldism |
| titel_suche | Graft-versus-host reaction affecting lesional skin but not normal skin in a patient with piebaldism |
| topic | WW-YZ |
| uid | nat_lic_papers_NLZ238982092 |