Does oestriol add to the beneficial effect of combined hormonal prophylaxis against early postmenopausal osteoporosis?

1471-0528

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Sixty-nine healthy women in the early menopause were assessed in terms of calcium metabolism, coronary risk factors, Kuerman index, and various serum hormones before and during replacement therapy with l7β-oestradiol plus oestriol and norethisterone acetate. The patients were followed for 1 year, and the daily doses used were: 17β-oestradiol: 2 mg from day 1 to day 22, 1 mg from day 23 to day 28; oestriol: 1 mg from day 1 to day 22, 0.5 mg from day 23 to day 28; and norethisterone acetate: 1 mg from day 13 to day 22. Group A (n=22) received 17β-oestradiol and norethisterone acetate; group B (n=20) received 17β-oestradiol plus oestriol and norethisterone acetate and group C (n=23) received a placebo. The responses in groups A and B were similar with no significant difference between the two therapy regimens. The results suggest that in the dose given, oestriol does not add significantly to the beneficial effect of combined hormonal prophylaxis against early postmenopausal osteoporosis.

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