The prognostic significance of the half-life of serum CA 125 in patients responding to chemotherapy for epithelial ovarian carcinoma
HAWKINS, R. E. ; ROBERTS, K. ; WILTSHAW, E. ; MUNDY, J. ; FRYATT, I. J. ; McCREADY, V.
Oxford, UK : Blackwell Publishing Ltd
Published 1989
Oxford, UK : Blackwell Publishing Ltd
Published 1989
| ISSN: |
1471-0528
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| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
Various prognostic factors were studied in 29 patients with stage III or IV ovarian cancer who responded to initial chemotherapy after initial diagnostic surgery. The half-life of CA 125 in serum during initial chemotherapy was the most important prognostic indicator for survival (P〈0·001) and the chance of achieving complete remission (P= 0·012). A CA 125 half-life of 〈20 days, 20–40 days and 〉40 days appears to identify patients with a good, intermediate or poor prognosis, the two year actuarial survival being 76%, 48% and 0% respectively. The chance of achieving a complete remission was 15% and 67% respectively for patients with a serum CA 125 half-life of 〉20 or 〈20 days.
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| Type of Medium: |
Electronic Resource
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| URL: |