DEMONSTRATION OF α-ADRENOCEPTOR ANTAGONISM BY THE 5HT2 ANTAGONIST, KETANSERIN (R49945), IN SHEEP
Nelson, M. A. ; Coghlan, J. P. ; Denton, D. A. ; Mills, E. H. ; Spence, C. D. ; Whitworth, J. A. ; Scoggins, B. A.
Oxford, UK : Blackwell Publishing Ltd
Published 1984
Oxford, UK : Blackwell Publishing Ltd
Published 1984
| ISSN: |
1440-1681
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| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
1. Serotonin causes a dose related (0.1–20 μg/kg i.v.) increase in mean arterial blood pressure (MAP) and heart rate in conscious sheep.2. Ketanserin (0.1 mg/kg per h i.v.) causes a decrease in blood pressure, and an increase in heart rate. In the presence of ketanserin, serotonin induced increases in MAP are attenuated, or abolished, but the increases in heart rate are enhanced.3. Ketanserin (10 mg/kg per h i.v.) attenuates or abolishes the increase in blood pressure induced by the α-adrenoceptor agonist phenylephrine in conscious sheep. When administered in the presence of the α-adrenoceptor antagonist prazosin, ketanserin (0.1 mg/kg per h i.v.) fails to induce a further hypotensive response.4. These data suggest that in the conscious sheep ketanserin exhibits predominantly α-adrenoceptor antagonism.
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| Type of Medium: |
Electronic Resource
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| URL: |