MICROINJECTION OF KAINIC ACID INTO THE ROSTRAL VENTROLATERAL MEDULLA CAUSES HYPERTENSION AND RELEASE OF NEUROPEPTIDE Y-LIKE IMMUNOREACTIVITY FROM RABBIT SPINAL CORD
Morris, M. J. ; Pilowsky, P. M. ; Minson, J. B. ; West, M. J. ; Chalmers, J. P.
Oxford, UK : Blackwell Publishing Ltd
Published 1987
Oxford, UK : Blackwell Publishing Ltd
Published 1987
| ISSN: |
1440-1681
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| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
SUMMARY1. Microinjections of kainic acid were made into the pressor area of the rostral ventrolateral medulla oblongata of anaesthetized rabbits, in the region of the C1 adrenaline-containing neurons.2. Over the 65 min following the microinjection, there was a significant increase in blood pressure, as well as an increase in the release of neuropeptide Y-like immunoreactivity into the spinal subarachnoid space.3. These data provide evidence for a functional bulbospinal neuropeptide Y-containing projection which may be responsible for mediating the pressor effects of stimulation of the rostral ventrolateral medulla.
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| Type of Medium: |
Electronic Resource
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| URL: |