INTERACTIONS BETWEEN 5-HYDROXYTRYPTAMINE, NORADRENALINE AND THE THROMBOXANE-A2 MIMETIC U44069 IN THE MARMOSET ISOLATED AORTA
Dyer, S. M. ; Bexis, S. ; Mano, M. T. ; Lande, I. S. ; Frewin, D. B. ; Head, R. J.
Oxford, UK : Blackwell Publishing Ltd
Published 1994
Oxford, UK : Blackwell Publishing Ltd
Published 1994
| ISSN: |
1440-1681
|
|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
|
| Topics: |
Medicine
|
| Notes: |
1. The effects of 5-hydroxytryptamine (5-HT) in the absence and presence of noradrenaline (NA) or the thromboxane-A2 mimetic, U44069, were investigated in ring preparations of marmoset aorta.2. 5-HT (0.001-10 μmol/L) produced little or no contractile response in preparations at basal tone. When the tone was elevated to 50% of maximum with NA the predominant response to 5-HT was relaxation. The 5-HT2 receptor antagonist LY53857 (0.1 μmol/L) unmasked a contractile response to low concentrations of 5-HT (0.01 - 1.0 μmol/L) and reduced relaxation to high concentrations of 5-HT (1.0-10 μmol/L) in vessels precontracted with NA.3. In U44069-contracted vessels, 5-HT was contractile in the range 0.01-1 μmol/L and relaxant in concentrations of 6.0-10.0 μmol/L. Ketanserin (1.0 μmol/L) had no effect on the contraction or relaxation to 5-HT.4. The relaxant response to 5-HT was not significantly diminished in endothelium-impaired arteries.5. In conclusion, 5-HT exerts complex inhibitory and excitatory actions on the marmoset aorta. The inhibitory actions are not endothelium-dependent and the excitatory actions do not appear to involve the 5-HT2 receptor.
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798290145130053632 |
|---|---|
| autor | Dyer, S. M. Bexis, S. Mano, M. T. Lande, I. S. Frewin, D. B. Head, R. J. |
| autorsonst | Lande, I. S. Frewin, D. B. Head, R. J. |
| book_url | http://dx.doi.org/10.1111/j.1440-1681.1994.tb02496.x |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLZ238601676 |
| insertion_date | 2012-04-17 |
| issn | 1440-1681 |
| journal_name | Clinical and experimental pharmacology and physiology |
| materialart | 1 |
| notes | 1. The effects of 5-hydroxytryptamine (5-HT) in the absence and presence of noradrenaline (NA) or the thromboxane-A2 mimetic, U44069, were investigated in ring preparations of marmoset aorta.2. 5-HT (0.001-10 μmol/L) produced little or no contractile response in preparations at basal tone. When the tone was elevated to 50% of maximum with NA the predominant response to 5-HT was relaxation. The 5-HT2 receptor antagonist LY53857 (0.1 μmol/L) unmasked a contractile response to low concentrations of 5-HT (0.01 - 1.0 μmol/L) and reduced relaxation to high concentrations of 5-HT (1.0-10 μmol/L) in vessels precontracted with NA.3. In U44069-contracted vessels, 5-HT was contractile in the range 0.01-1 μmol/L and relaxant in concentrations of 6.0-10.0 μmol/L. Ketanserin (1.0 μmol/L) had no effect on the contraction or relaxation to 5-HT.4. The relaxant response to 5-HT was not significantly diminished in endothelium-impaired arteries.5. In conclusion, 5-HT exerts complex inhibitory and excitatory actions on the marmoset aorta. The inhibitory actions are not endothelium-dependent and the excitatory actions do not appear to involve the 5-HT2 receptor. |
| package_name | Blackwell Publishing |
| publikationsjahr_anzeige | 1994 |
| publikationsjahr_facette | 1994 |
| publikationsjahr_intervall | 8009:1990-1994 |
| publikationsjahr_sort | 1994 |
| publikationsort | Oxford, UK |
| publisher | Blackwell Publishing Ltd |
| reference | 21 (1994), S. 0 |
| search_space | articles |
| shingle_author_1 | Dyer, S. M. Bexis, S. Mano, M. T. Lande, I. S. Frewin, D. B. Head, R. J. |
| shingle_author_2 | Dyer, S. M. Bexis, S. Mano, M. T. Lande, I. S. Frewin, D. B. Head, R. J. |
| shingle_author_3 | Dyer, S. M. Bexis, S. Mano, M. T. Lande, I. S. Frewin, D. B. Head, R. J. |
| shingle_author_4 | Dyer, S. M. Bexis, S. Mano, M. T. Lande, I. S. Frewin, D. B. Head, R. J. |
| shingle_catch_all_1 | Dyer, S. M. Bexis, S. Mano, M. T. Lande, I. S. Frewin, D. B. Head, R. J. INTERACTIONS BETWEEN 5-HYDROXYTRYPTAMINE, NORADRENALINE AND THE THROMBOXANE-A2 MIMETIC U44069 IN THE MARMOSET ISOLATED AORTA Blackwell Publishing Ltd 1. The effects of 5-hydroxytryptamine (5-HT) in the absence and presence of noradrenaline (NA) or the thromboxane-A2 mimetic, U44069, were investigated in ring preparations of marmoset aorta.2. 5-HT (0.001-10 μmol/L) produced little or no contractile response in preparations at basal tone. When the tone was elevated to 50% of maximum with NA the predominant response to 5-HT was relaxation. The 5-HT2 receptor antagonist LY53857 (0.1 μmol/L) unmasked a contractile response to low concentrations of 5-HT (0.01 - 1.0 μmol/L) and reduced relaxation to high concentrations of 5-HT (1.0-10 μmol/L) in vessels precontracted with NA.3. In U44069-contracted vessels, 5-HT was contractile in the range 0.01-1 μmol/L and relaxant in concentrations of 6.0-10.0 μmol/L. Ketanserin (1.0 μmol/L) had no effect on the contraction or relaxation to 5-HT.4. The relaxant response to 5-HT was not significantly diminished in endothelium-impaired arteries.5. In conclusion, 5-HT exerts complex inhibitory and excitatory actions on the marmoset aorta. The inhibitory actions are not endothelium-dependent and the excitatory actions do not appear to involve the 5-HT2 receptor. 1440-1681 14401681 |
| shingle_catch_all_2 | Dyer, S. M. Bexis, S. Mano, M. T. Lande, I. S. Frewin, D. B. Head, R. J. INTERACTIONS BETWEEN 5-HYDROXYTRYPTAMINE, NORADRENALINE AND THE THROMBOXANE-A2 MIMETIC U44069 IN THE MARMOSET ISOLATED AORTA Blackwell Publishing Ltd 1. The effects of 5-hydroxytryptamine (5-HT) in the absence and presence of noradrenaline (NA) or the thromboxane-A2 mimetic, U44069, were investigated in ring preparations of marmoset aorta.2. 5-HT (0.001-10 μmol/L) produced little or no contractile response in preparations at basal tone. When the tone was elevated to 50% of maximum with NA the predominant response to 5-HT was relaxation. The 5-HT2 receptor antagonist LY53857 (0.1 μmol/L) unmasked a contractile response to low concentrations of 5-HT (0.01 - 1.0 μmol/L) and reduced relaxation to high concentrations of 5-HT (1.0-10 μmol/L) in vessels precontracted with NA.3. In U44069-contracted vessels, 5-HT was contractile in the range 0.01-1 μmol/L and relaxant in concentrations of 6.0-10.0 μmol/L. Ketanserin (1.0 μmol/L) had no effect on the contraction or relaxation to 5-HT.4. The relaxant response to 5-HT was not significantly diminished in endothelium-impaired arteries.5. In conclusion, 5-HT exerts complex inhibitory and excitatory actions on the marmoset aorta. The inhibitory actions are not endothelium-dependent and the excitatory actions do not appear to involve the 5-HT2 receptor. 1440-1681 14401681 |
| shingle_catch_all_3 | Dyer, S. M. Bexis, S. Mano, M. T. Lande, I. S. Frewin, D. B. Head, R. J. INTERACTIONS BETWEEN 5-HYDROXYTRYPTAMINE, NORADRENALINE AND THE THROMBOXANE-A2 MIMETIC U44069 IN THE MARMOSET ISOLATED AORTA Blackwell Publishing Ltd 1. The effects of 5-hydroxytryptamine (5-HT) in the absence and presence of noradrenaline (NA) or the thromboxane-A2 mimetic, U44069, were investigated in ring preparations of marmoset aorta.2. 5-HT (0.001-10 μmol/L) produced little or no contractile response in preparations at basal tone. When the tone was elevated to 50% of maximum with NA the predominant response to 5-HT was relaxation. The 5-HT2 receptor antagonist LY53857 (0.1 μmol/L) unmasked a contractile response to low concentrations of 5-HT (0.01 - 1.0 μmol/L) and reduced relaxation to high concentrations of 5-HT (1.0-10 μmol/L) in vessels precontracted with NA.3. In U44069-contracted vessels, 5-HT was contractile in the range 0.01-1 μmol/L and relaxant in concentrations of 6.0-10.0 μmol/L. Ketanserin (1.0 μmol/L) had no effect on the contraction or relaxation to 5-HT.4. The relaxant response to 5-HT was not significantly diminished in endothelium-impaired arteries.5. In conclusion, 5-HT exerts complex inhibitory and excitatory actions on the marmoset aorta. The inhibitory actions are not endothelium-dependent and the excitatory actions do not appear to involve the 5-HT2 receptor. 1440-1681 14401681 |
| shingle_catch_all_4 | Dyer, S. M. Bexis, S. Mano, M. T. Lande, I. S. Frewin, D. B. Head, R. J. INTERACTIONS BETWEEN 5-HYDROXYTRYPTAMINE, NORADRENALINE AND THE THROMBOXANE-A2 MIMETIC U44069 IN THE MARMOSET ISOLATED AORTA Blackwell Publishing Ltd 1. The effects of 5-hydroxytryptamine (5-HT) in the absence and presence of noradrenaline (NA) or the thromboxane-A2 mimetic, U44069, were investigated in ring preparations of marmoset aorta.2. 5-HT (0.001-10 μmol/L) produced little or no contractile response in preparations at basal tone. When the tone was elevated to 50% of maximum with NA the predominant response to 5-HT was relaxation. The 5-HT2 receptor antagonist LY53857 (0.1 μmol/L) unmasked a contractile response to low concentrations of 5-HT (0.01 - 1.0 μmol/L) and reduced relaxation to high concentrations of 5-HT (1.0-10 μmol/L) in vessels precontracted with NA.3. In U44069-contracted vessels, 5-HT was contractile in the range 0.01-1 μmol/L and relaxant in concentrations of 6.0-10.0 μmol/L. Ketanserin (1.0 μmol/L) had no effect on the contraction or relaxation to 5-HT.4. The relaxant response to 5-HT was not significantly diminished in endothelium-impaired arteries.5. In conclusion, 5-HT exerts complex inhibitory and excitatory actions on the marmoset aorta. The inhibitory actions are not endothelium-dependent and the excitatory actions do not appear to involve the 5-HT2 receptor. 1440-1681 14401681 |
| shingle_title_1 | INTERACTIONS BETWEEN 5-HYDROXYTRYPTAMINE, NORADRENALINE AND THE THROMBOXANE-A2 MIMETIC U44069 IN THE MARMOSET ISOLATED AORTA |
| shingle_title_2 | INTERACTIONS BETWEEN 5-HYDROXYTRYPTAMINE, NORADRENALINE AND THE THROMBOXANE-A2 MIMETIC U44069 IN THE MARMOSET ISOLATED AORTA |
| shingle_title_3 | INTERACTIONS BETWEEN 5-HYDROXYTRYPTAMINE, NORADRENALINE AND THE THROMBOXANE-A2 MIMETIC U44069 IN THE MARMOSET ISOLATED AORTA |
| shingle_title_4 | INTERACTIONS BETWEEN 5-HYDROXYTRYPTAMINE, NORADRENALINE AND THE THROMBOXANE-A2 MIMETIC U44069 IN THE MARMOSET ISOLATED AORTA |
| sigel_instance_filter | dkfz geomar wilbert ipn albert |
| source_archive | Blackwell Publishing Journal Backfiles 1879-2005 |
| timestamp | 2024-05-06T08:12:04.178Z |
| titel | INTERACTIONS BETWEEN 5-HYDROXYTRYPTAMINE, NORADRENALINE AND THE THROMBOXANE-A2 MIMETIC U44069 IN THE MARMOSET ISOLATED AORTA |
| titel_suche | INTERACTIONS BETWEEN 5-HYDROXYTRYPTAMINE, NORADRENALINE AND THE THROMBOXANE-A2 MIMETIC U44069 IN THE MARMOSET ISOLATED AORTA |
| topic | WW-YZ |
| uid | nat_lic_papers_NLZ238601676 |