Darier's disease: a focal abnormality of cell adhesion
Burge, S. M. ; Millard, P. R. ; Wojnarowska, F. ; Ryan, T. J.
Oxford, UK : Blackwell Publishing Ltd
Published 1990
Oxford, UK : Blackwell Publishing Ltd
Published 1990
| ISSN: |
1600-0560
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|---|---|
| Source: |
Blackwell Publishing Journal Backfiles 1879-2005
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| Topics: |
Medicine
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| Notes: |
Cell adhesion in clinically normal and involved skin in Darier's disease has been investigated using a suction blister technique. We have been unable to detect a subclinical abnormality in cell adhesion which could predispose to the development of acantholytic papules. There may be synthesis of functionally deficient desmosomes, increased breakdown of desmosomes or abnormalities in other adhesion proteins on the surface of the keradnocyte in Darier's disease, but the abnormality in adhesion is focal and restricted to the clinically and histologically abnormal papules.
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| Type of Medium: |
Electronic Resource
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| URL: |