Targeting of non-lg sequences in place of the V segment by somatic hyper mutation
Yélamos, J. ; Klix, N. ; Goyenechea, B. ; Lozano, F. ; Chui, Y. L. ; FernÃndez, A. GonzÃlez ; Pannell, R. ; Neuberger, M. S. ; Milstein, C.
[s.l.] : Nature Publishing Group
Published 1995
[s.l.] : Nature Publishing Group
Published 1995
| ISSN: |
1476-4687
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|---|---|
| Source: |
Nature Archives 1869 - 2009
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| Topics: |
Biology
Chemistry and Pharmacology
Medicine
Natural Sciences in General
Physics
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| Notes: |
[Auszug] Affinity maturation of antibodies is characterized by localized hypermutation of the DNA around the V segment. Here we show, using mice containing single or multiple transgene constructs, that an immunoglobulin VK segment can be replaced by human β-globin or prokaryotic neo or gpt ...
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| Type of Medium: |
Electronic Resource
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| URL: |