Conversion of thrombin into an anticoagulant by protein engineering
Gibbs, C. S. ; Coutré, S. E. ; Tsiang, M. ; Li, W-X. ; Jain, A. K. ; Dunn, K. E. ; Law, V. S. ; Mao, C. T. ; Matsumura, S. Y. ; Mejza, S. Y. ; Paborsky, L. R. ; Leung, L. L. K.
[s.l.] : Nature Publishing Group
Published 1995
[s.l.] : Nature Publishing Group
Published 1995
| ISSN: |
1476-4687
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|---|---|
| Source: |
Nature Archives 1869 - 2009
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| Topics: |
Biology
Chemistry and Pharmacology
Medicine
Natural Sciences in General
Physics
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| Notes: |
[Auszug] A library of 62 thrombin mutants11, in which the solvent-exposed charged and polar amino acids were substituted with alanine, was screened for mutants that were defective in fibrin-ogen clotting yet retained their ability to activate protein C in the presence of thrombomodulin. One mutation, E229A, ...
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| Type of Medium: |
Electronic Resource
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| URL: |