Dopaminergic supersensitivity induced by denervation and chronic receptor blockade is additive

Staunton, D. A. ; Magistretti, P. J. ; Koob, G. F. ; Shoemaker, W. J. ; Bloom, F. E.

[s.l.] : Nature Publishing Group
Published 1982
ISSN:
1476-4687
Source:
Nature Archives 1869 - 2009
Topics:
Biology
Chemistry and Pharmacology
Medicine
Natural Sciences in General
Physics
Notes:
[Auszug] Male Sprague-Dawley rats (Charles River Laboratories; mean weight 305 g) were used. To study denervation super-sensitivity, 8 jjig of 6-hydroxydopamine were injected into the nucleus accumbens on each side as previously described14. Sham-treated control subjects were prepared with bilateral ...
Type of Medium:
Electronic Resource
URL: