Creation of Mice Expressing Human Antibody Light Chains by Introduction of a Yeast Artificial Chromosome Containing the Core Region of the Human Immunoglobulin κ Locus
Davies, Nicholas P. ; Rosewell, Ian R. ; Richardson, Jenny C. ; Cook, Graham P. ; Neuberger, Michael S. ; Brownstein, Bernard H. ; Norris, Mike L. ; Brüggemann, Marianne
[s.l.] : Nature Publishing Company
Published 1993
[s.l.] : Nature Publishing Company
Published 1993
| ISSN: |
1546-1696
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|---|---|
| Source: |
Nature Archives 1869 - 2009
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| Topics: |
Biology
Process Engineering, Biotechnology, Nutrition Technology
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| Notes: |
[Auszug] We have previously described a strategy for integrating selectable marker genes into yeast artificial chromosomes (YACs) to facilitate their transfer into embryonic stem (ES) cells. Here we apply this technology to create mice carrying the core region of the human immunoglobulin (Ig) κ light ...
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| Type of Medium: |
Electronic Resource
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| URL: |