Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia
Graux, C. ; Cools, J. ; Melotte, C. ; Quentmeier, H. ; Ferrando, A. ; Levine, R. ; Vermeesch, J.R. ; Stul, M. ; Dutta, B. ; Boeckx, N. ; Bosly, A. ; Heimann, P. ; Uyttebroeck, A. ; Mentens, N. ; Somers, R. ; MacLeod, R.A.F. ; Drexler, H.G. ; Look, A.T. ; Gilliland, D.G. ; Michaux, L. ; Vandenberghe, P. ; Wlodarska, I. ; Marynen, Peter ; Hagemeijer, Anne
[s.l.] : Nature Publishing Group
Published 2004
[s.l.] : Nature Publishing Group
Published 2004
| ISSN: |
1546-1718
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|---|---|
| Source: |
Nature Archives 1869 - 2009
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| Topics: |
Biology
Medicine
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| Notes: |
[Auszug] In T-cell acute lymphoblastic leukemia (T-ALL), transcription factors are known to be deregulated by chromosomal translocations, but mutations in protein tyrosine kinases have only rarely been identified. Here we describe the extrachromosomal (episomal) amplification of ABL1 in 5 of 90 (5.6%) ...
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| Type of Medium: |
Electronic Resource
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| URL: |