De novo expansion of a (CAG) n repeat in sporadic Huntington's disease
Myers, R. H. ; MacDonald, M. E. ; Koroshetz, W. J. ; Duyao, M. P. ; Ambrose, C. M. ; Taylor, S. A. M. ; Barnes, G. ; Srinidhi, J. ; Lin, C. S. ; Whaley, W. L. ; Lazzarini, A. M. ; Schwarz, M. ; Wolff, G. ; Bird, E. D. ; Vonsattel, J.-P. G. ; Gusella, J. F.
[s.l.] : Nature Publishing Group
Published 1993
[s.l.] : Nature Publishing Group
Published 1993
| ISSN: |
1546-1718
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|---|---|
| Source: |
Nature Archives 1869 - 2009
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| Topics: |
Biology
Medicine
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| Notes: |
[Auszug] Huntington's disease (HD) chromosomes contain an expanded unstable (CAG)n repeat in chromosome 4p16.3. We have examined nine families with potential de novo expression of the disease. With one exception, all of the affected individuals had 42 or more repeat units, well above the normal range. In ...
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| Type of Medium: |
Electronic Resource
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| URL: |