Killed but metabolically active microbes: a new vaccine paradigm for eliciting effector T-cell responses and protective immunity
Brockstedt, D G ; Bahjat, K S ; Giedlin, M A ; Liu, W ; Leong, M ; Luckett, W ; Gao, Y ; Schnupf, P ; Kapadia, D ; Castro, G ; Lim, J Y H ; Sampson-Johannes, A ; Herskovits, A A ; Stassinopoulos, A ; Bouwer, H G Archie ; Hearst, J E ; Portnoy, D A ; Cook, D N ; Dubensky, T W
[s.l.] : Nature Publishing Group
Published 2005
[s.l.] : Nature Publishing Group
Published 2005
| ISSN: |
1546-170X
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|---|---|
| Source: |
Nature Archives 1869 - 2009
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| Topics: |
Biology
Medicine
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| Notes: |
[Auszug] We developed a new class of vaccines, based on killed but metabolically active (KBMA) bacteria, that simultaneously takes advantage of the potency of live vaccines and the safety of killed vaccines. We removed genes required for nucleotide excision repair (uvrAB), rendering microbial-based vaccines ...
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| Type of Medium: |
Electronic Resource
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| URL: |