Founding mutations and Alu-mediated recombination in hereditary colon cancer
Nyström-Lahti, Minna ; Kristo, Paula ; Nicolaides, Nicholas C. ; Chang, Sheng-Yung ; Aaltonen, Lauri A. ; Moisio, Anu-Liisa ; Järvinen, Heikki J. ; Mecklin, Jukka-Pekka ; Kinzler, Kenneth W. ; Vogelstein, Bert ; De La Chapelle, Albert ; Peltomäki, Päivi
[s.l.] : Nature Publishing Group
Published 1995
[s.l.] : Nature Publishing Group
Published 1995
| ISSN: |
1546-170X
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|---|---|
| Source: |
Nature Archives 1869 - 2009
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| Topics: |
Biology
Medicine
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| Notes: |
[Auszug] By screening members of Finnish families displaying hereditary nonpolyposis colorectal cancer (HNPCC) for predisposing germline mutations in MSH2 and MLH1, we show that two mutations in MLH1 together account for 63% (19/30) of kindreds meeting international diagnostic criteria. Mutation 1, ...
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| Type of Medium: |
Electronic Resource
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| URL: |