A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer
DiGiammarino, Enrico L. ; Lee, Amanda S. ; Cadwell, Craig ; Zhang, Weixing ; Bothner, Brian ; Ribeiro, Raul C. ; Zambetti, Gerard ; Kriwacki, Richard W.
[s.l.] : Nature Publishing Group
Published 2002
[s.l.] : Nature Publishing Group
Published 2002
| ISSN: |
1072-8368
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|---|---|
| Source: |
Nature Archives 1869 - 2009
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| Topics: |
Biology
Medicine
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| Notes: |
[Auszug] The p53 tumor suppressor requires tetramerization to function as an initiator of cell cycle arrest and/or apoptosis. Children in southern Brazil that exhibit an elevated incidence of adrenocortical carcinoma (ACC) harbor an Arg 337 to His mutation within the tetramerization domain of p53 ...
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| Type of Medium: |
Electronic Resource
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| URL: |