Interactions of dicarboxylic porphyrins with membranes in relation to their ionization state
| ISSN: |
1011-1344
|
|---|---|
| Keywords: |
Fluorescence ; Ionization ; Kinetics ; Membrane models ; Partition ; Photodynamic therapy ; Porphyrins ; Small unilamellar vesicles ; pH
|
| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
|
| Topics: |
Biology
Chemistry and Pharmacology
Medicine
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798292151080058881 |
|---|---|
| autor | Brault, D. Vever-Bizet, C. Kuzelova, K. |
| autorsonst | Brault, D. Vever-Bizet, C. Kuzelova, K. |
| book_url | http://linkinghub.elsevier.com/retrieve/pii/1011-1344(93)80150-8 |
| datenlieferant | nat_lic_papers |
| fussnote | The interactions of dicarboxylic porphyrins with membrane systems are discussed with particular emphasis on the effect of the charge of the porphyrin and the nature of the side-chains. The incorporation of hematoporphyrin or related dicarboxylic porphyrins within small unilamellar vesicles as membrane models is favored by a decrease of the pH in the range of physiological pH values. This effect might play an important role in the retention of porphyrins by tumors, which are more acidic than normal tissues. Kinetics studies also show that the partition of the porphyrin between the lipidic bilayer and the aqueous phase is governed by its release rate rather than by its incorporation rate. |
| hauptsatz | hsatz_simple |
| identnr | NLZ188459774 |
| issn | 1011-1344 |
| journal_name | Journal of Photochemistry and Photobiology B: Biology |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 20 (1993), S. 191-195 |
| schlagwort | Fluorescence Ionization Kinetics Membrane models Partition Photodynamic therapy Porphyrins Small unilamellar vesicles pH |
| search_space | articles |
| shingle_author_1 | Brault, D. Vever-Bizet, C. Kuzelova, K. |
| shingle_author_2 | Brault, D. Vever-Bizet, C. Kuzelova, K. |
| shingle_author_3 | Brault, D. Vever-Bizet, C. Kuzelova, K. |
| shingle_author_4 | Brault, D. Vever-Bizet, C. Kuzelova, K. |
| shingle_catch_all_1 | Brault, D. Vever-Bizet, C. Kuzelova, K. Interactions of dicarboxylic porphyrins with membranes in relation to their ionization state Fluorescence Ionization Kinetics Membrane models Partition Photodynamic therapy Porphyrins Small unilamellar vesicles pH Fluorescence Ionization Kinetics Membrane models Partition Photodynamic therapy Porphyrins Small unilamellar vesicles pH 1011-1344 10111344 Elsevier |
| shingle_catch_all_2 | Brault, D. Vever-Bizet, C. Kuzelova, K. Interactions of dicarboxylic porphyrins with membranes in relation to their ionization state Fluorescence Ionization Kinetics Membrane models Partition Photodynamic therapy Porphyrins Small unilamellar vesicles pH Fluorescence Ionization Kinetics Membrane models Partition Photodynamic therapy Porphyrins Small unilamellar vesicles pH 1011-1344 10111344 Elsevier |
| shingle_catch_all_3 | Brault, D. Vever-Bizet, C. Kuzelova, K. Interactions of dicarboxylic porphyrins with membranes in relation to their ionization state Fluorescence Ionization Kinetics Membrane models Partition Photodynamic therapy Porphyrins Small unilamellar vesicles pH Fluorescence Ionization Kinetics Membrane models Partition Photodynamic therapy Porphyrins Small unilamellar vesicles pH 1011-1344 10111344 Elsevier |
| shingle_catch_all_4 | Brault, D. Vever-Bizet, C. Kuzelova, K. Interactions of dicarboxylic porphyrins with membranes in relation to their ionization state Fluorescence Ionization Kinetics Membrane models Partition Photodynamic therapy Porphyrins Small unilamellar vesicles pH Fluorescence Ionization Kinetics Membrane models Partition Photodynamic therapy Porphyrins Small unilamellar vesicles pH 1011-1344 10111344 Elsevier |
| shingle_title_1 | Interactions of dicarboxylic porphyrins with membranes in relation to their ionization state |
| shingle_title_2 | Interactions of dicarboxylic porphyrins with membranes in relation to their ionization state |
| shingle_title_3 | Interactions of dicarboxylic porphyrins with membranes in relation to their ionization state |
| shingle_title_4 | Interactions of dicarboxylic porphyrins with membranes in relation to their ionization state |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:43:57.032Z |
| titel | Interactions of dicarboxylic porphyrins with membranes in relation to their ionization state |
| titel_suche | Interactions of dicarboxylic porphyrins with membranes in relation to their ionization state The interactions of dicarboxylic porphyrins with membrane systems are discussed with particular emphasis on the effect of the charge of the porphyrin and the nature of the side-chains. The incorporation of hematoporphyrin or related dicarboxylic porphyrins within small unilamellar vesicles as membrane models is favored by a decrease of the pH in the range of physiological pH values. This effect might play an important role in the retention of porphyrins by tumors, which are more acidic than normal tissues. Kinetics studies also show that the partition of the porphyrin between the lipidic bilayer and the aqueous phase is governed by its release rate rather than by its incorporation rate. |
| topic | W V WW-YZ |
| uid | nat_lic_papers_NLZ188459774 |