High-performance liquid chromatographic determination of N-methylformamide and N-methyl-N-(hydroxymethyl)-formamide in human urine
Santoni, G. ; Bavazzano, P. ; Perico, A. ; Colzi, A. ; Benassi, S. ; Medica, A. ; La Morgia, R. ; Giuliano, G.
Amsterdam : Elsevier
Amsterdam : Elsevier
| ISSN: |
0378-4347
|
|---|---|
| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
|
| Topics: |
Chemistry and Pharmacology
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798292018256936961 |
|---|---|
| autor | Santoni, G. Bavazzano, P. Perico, A. Colzi, A. Benassi, S. Medica, A. La Morgia, R. Giuliano, G. |
| autorsonst | Santoni, G. Bavazzano, P. Perico, A. Colzi, A. Benassi, S. Medica, A. La Morgia, R. Giuliano, G. |
| book_url | http://linkinghub.elsevier.com/retrieve/pii/0378-4347(92)80284-W |
| datenlieferant | nat_lic_papers |
| fussnote | A reliable high-performance liquid chromatographic (HPLC) method which allows the determination in human urine of two important metabolites of N,N-dimethylformamide (DMF), namely N-methylformamide (MMF) and N-methyl-N-(hydroxymethyl)formamide (DMFOH), is reported. A single-step rapid purification of urine was performed on a C"1"8 solid-phase extraction column and the eluate was injected directly on to the HPLC column. HPLC was carried out isocratically on Aminex Ion Exclusion HPX-87H column using 7.5 . 10^-^4 M sulphuric acid as the mobile phase with ultraviolet detection at 196 nm. The method is specific, accurate, precise and sufficiently sensitive to be applied to the biological monitoring of MMF and DMFOH in workers exposed to DMF. |
| hauptsatz | hsatz_simple |
| identnr | NLZ188306528 |
| issn | 0378-4347 |
| journal_name | Journal of Chromatography B: Biomedical Sciences and Applications |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 581 (1992), S. 287-292 |
| search_space | articles |
| shingle_author_1 | Santoni, G. Bavazzano, P. Perico, A. Colzi, A. Benassi, S. Medica, A. La Morgia, R. Giuliano, G. |
| shingle_author_2 | Santoni, G. Bavazzano, P. Perico, A. Colzi, A. Benassi, S. Medica, A. La Morgia, R. Giuliano, G. |
| shingle_author_3 | Santoni, G. Bavazzano, P. Perico, A. Colzi, A. Benassi, S. Medica, A. La Morgia, R. Giuliano, G. |
| shingle_author_4 | Santoni, G. Bavazzano, P. Perico, A. Colzi, A. Benassi, S. Medica, A. La Morgia, R. Giuliano, G. |
| shingle_catch_all_1 | Santoni, G. Bavazzano, P. Perico, A. Colzi, A. Benassi, S. Medica, A. La Morgia, R. Giuliano, G. High-performance liquid chromatographic determination of N-methylformamide and N-methyl-N-(hydroxymethyl)-formamide in human urine 0378-4347 03784347 Elsevier |
| shingle_catch_all_2 | Santoni, G. Bavazzano, P. Perico, A. Colzi, A. Benassi, S. Medica, A. La Morgia, R. Giuliano, G. High-performance liquid chromatographic determination of N-methylformamide and N-methyl-N-(hydroxymethyl)-formamide in human urine 0378-4347 03784347 Elsevier |
| shingle_catch_all_3 | Santoni, G. Bavazzano, P. Perico, A. Colzi, A. Benassi, S. Medica, A. La Morgia, R. Giuliano, G. High-performance liquid chromatographic determination of N-methylformamide and N-methyl-N-(hydroxymethyl)-formamide in human urine 0378-4347 03784347 Elsevier |
| shingle_catch_all_4 | Santoni, G. Bavazzano, P. Perico, A. Colzi, A. Benassi, S. Medica, A. La Morgia, R. Giuliano, G. High-performance liquid chromatographic determination of N-methylformamide and N-methyl-N-(hydroxymethyl)-formamide in human urine 0378-4347 03784347 Elsevier |
| shingle_title_1 | High-performance liquid chromatographic determination of N-methylformamide and N-methyl-N-(hydroxymethyl)-formamide in human urine |
| shingle_title_2 | High-performance liquid chromatographic determination of N-methylformamide and N-methyl-N-(hydroxymethyl)-formamide in human urine |
| shingle_title_3 | High-performance liquid chromatographic determination of N-methylformamide and N-methyl-N-(hydroxymethyl)-formamide in human urine |
| shingle_title_4 | High-performance liquid chromatographic determination of N-methylformamide and N-methyl-N-(hydroxymethyl)-formamide in human urine |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:41:50.590Z |
| titel | High-performance liquid chromatographic determination of N-methylformamide and N-methyl-N-(hydroxymethyl)-formamide in human urine |
| titel_suche | High-performance liquid chromatographic determination of N-methylformamide and N-methyl-N-(hydroxymethyl)-formamide in human urine A reliable high-performance liquid chromatographic (HPLC) method which allows the determination in human urine of two important metabolites of N,N-dimethylformamide (DMF), namely N-methylformamide (MMF) and N-methyl-N-(hydroxymethyl)formamide (DMFOH), is reported. A single-step rapid purification of urine was performed on a C"1"8 solid-phase extraction column and the eluate was injected directly on to the HPLC column. HPLC was carried out isocratically on Aminex Ion Exclusion HPX-87H column using 7.5 . 10^-^4 M sulphuric acid as the mobile phase with ultraviolet detection at 196 nm. The method is specific, accurate, precise and sufficiently sensitive to be applied to the biological monitoring of MMF and DMFOH in workers exposed to DMF. |
| topic | V |
| uid | nat_lic_papers_NLZ188306528 |