Androstenedione metabolism in streptozotocin diabetes and fasting male rats: Similarities and differences
| ISSN: |
0300-9629
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|---|---|
| Keywords: |
2β-OHA ; 6β-OHA ; Androstenedione ; Fasting male rats ; Insulin treatment ; Streptozotocin diabetes
|
| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
|
| Topics: |
Biology
Chemistry and Pharmacology
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798291776899907585 |
|---|---|
| autor | Valdes, E. Orellana, M. Del Villar, E. Vargas, M. |
| autorsonst | Valdes, E. Orellana, M. Del Villar, E. Vargas, M. |
| book_url | http://dx.doi.org/10.1016/0300-9629(94)90304-2 |
| datenlieferant | nat_lic_papers |
| fussnote | The oxidation products of androstenedione catalysed by liver microsomes from streptozotocin-diabetic and fasting male rats have been studied. Diabetic and starved rats displayed increased activity for 7α androstenedione hydroxylase and diminished activity for 16a androstenedione hydroxylase in comparison to the normal animals. Insulin treatment to diabetic rats did not antagonize the changes observed in untreated diabetic rats. Opposite to the diabetic state, the rate of 6β-OHA and 2β-OHA formation were increased in the course of the starved periods. The results suggest that under diabetes and fasting conditions distinct alterations occur in specific individual cytochrome P-450s. |
| hauptsatz | hsatz_simple |
| identnr | NLZ187804133 |
| issn | 0300-9629 |
| journal_name | Comparative Biochemistry and Physiology -- Part A: Physiology |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 107 (1994), S. 261-267 |
| schlagwort | 2β-OHA 6β-OHA Androstenedione Fasting male rats Insulin treatment Streptozotocin diabetes |
| search_space | articles |
| shingle_author_1 | Valdes, E. Orellana, M. Del Villar, E. Vargas, M. |
| shingle_author_2 | Valdes, E. Orellana, M. Del Villar, E. Vargas, M. |
| shingle_author_3 | Valdes, E. Orellana, M. Del Villar, E. Vargas, M. |
| shingle_author_4 | Valdes, E. Orellana, M. Del Villar, E. Vargas, M. |
| shingle_catch_all_1 | Valdes, E. Orellana, M. Del Villar, E. Vargas, M. Androstenedione metabolism in streptozotocin diabetes and fasting male rats: Similarities and differences 2β-OHA 6β-OHA Androstenedione Fasting male rats Insulin treatment Streptozotocin diabetes 2β-OHA 6β-OHA Androstenedione Fasting male rats Insulin treatment Streptozotocin diabetes 0300-9629 03009629 Elsevier |
| shingle_catch_all_2 | Valdes, E. Orellana, M. Del Villar, E. Vargas, M. Androstenedione metabolism in streptozotocin diabetes and fasting male rats: Similarities and differences 2β-OHA 6β-OHA Androstenedione Fasting male rats Insulin treatment Streptozotocin diabetes 2β-OHA 6β-OHA Androstenedione Fasting male rats Insulin treatment Streptozotocin diabetes 0300-9629 03009629 Elsevier |
| shingle_catch_all_3 | Valdes, E. Orellana, M. Del Villar, E. Vargas, M. Androstenedione metabolism in streptozotocin diabetes and fasting male rats: Similarities and differences 2β-OHA 6β-OHA Androstenedione Fasting male rats Insulin treatment Streptozotocin diabetes 2β-OHA 6β-OHA Androstenedione Fasting male rats Insulin treatment Streptozotocin diabetes 0300-9629 03009629 Elsevier |
| shingle_catch_all_4 | Valdes, E. Orellana, M. Del Villar, E. Vargas, M. Androstenedione metabolism in streptozotocin diabetes and fasting male rats: Similarities and differences 2β-OHA 6β-OHA Androstenedione Fasting male rats Insulin treatment Streptozotocin diabetes 2β-OHA 6β-OHA Androstenedione Fasting male rats Insulin treatment Streptozotocin diabetes 0300-9629 03009629 Elsevier |
| shingle_title_1 | Androstenedione metabolism in streptozotocin diabetes and fasting male rats: Similarities and differences |
| shingle_title_2 | Androstenedione metabolism in streptozotocin diabetes and fasting male rats: Similarities and differences |
| shingle_title_3 | Androstenedione metabolism in streptozotocin diabetes and fasting male rats: Similarities and differences |
| shingle_title_4 | Androstenedione metabolism in streptozotocin diabetes and fasting male rats: Similarities and differences |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:37:59.766Z |
| titel | Androstenedione metabolism in streptozotocin diabetes and fasting male rats: Similarities and differences |
| titel_suche | Androstenedione metabolism in streptozotocin diabetes and fasting male rats: Similarities and differences The oxidation products of androstenedione catalysed by liver microsomes from streptozotocin-diabetic and fasting male rats have been studied. Diabetic and starved rats displayed increased activity for 7α androstenedione hydroxylase and diminished activity for 16a androstenedione hydroxylase in comparison to the normal animals. Insulin treatment to diabetic rats did not antagonize the changes observed in untreated diabetic rats. Opposite to the diabetic state, the rate of 6β-OHA and 2β-OHA formation were increased in the course of the starved periods. The results suggest that under diabetes and fasting conditions distinct alterations occur in specific individual cytochrome P-450s. |
| topic | W V |
| uid | nat_lic_papers_NLZ187804133 |