The effects of ionophore A23187 on erythrocytes relationship of ATP and 2,3-diphosphoglycerate to calcium-binding capacity
| ISSN: |
0005-2736
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|---|---|
| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
|
| Topics: |
Biology
Chemistry and Pharmacology
Medicine
Physics
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798292210528026624 |
|---|---|
| autor | Edmondson, J.W. Li, T.-K. |
| autorsonst | Edmondson, J.W. Li, T.-K. |
| book_url | http://dx.doi.org/10.1016/0005-2736(76)90494-6 |
| datenlieferant | nat_lic_papers |
| fussnote | The divalent cation ionophore, A23187, was employed as a means to load fresh human erythrocytes with calcium, and the capacity for accumulation was characterized. Erythrocytes exposed to A23187 in calcium-containing media rapidly accumulated calcium in millimolar quantities. The final cellular concentration was dependent upon medium calcium concentration and the size of the cellular organophosphate pool. When ATP and 2,3-diphosphoglycerate contents were depleted or repleted, the cellular calcium content changed proportionally. Calcium loading of fresh erythrocytes produced no discernible change in the cellular concentrations of ATP or 2,3-diphosphoglycerate. Calcium accumulation was also accompanied by loss of cellular potassium and H"2O, deterioration of cell filterability, and spheroechinocytic transformation. |
| hauptsatz | hsatz_simple |
| identnr | NLZ187664544 |
| issn | 0005-2736 |
| journal_name | Biochimica et Biophysica Acta (BBA)/Biomembranes |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 443 (1976), S. 106-113 |
| search_space | articles |
| shingle_author_1 | Edmondson, J.W. Li, T.-K. |
| shingle_author_2 | Edmondson, J.W. Li, T.-K. |
| shingle_author_3 | Edmondson, J.W. Li, T.-K. |
| shingle_author_4 | Edmondson, J.W. Li, T.-K. |
| shingle_catch_all_1 | Edmondson, J.W. Li, T.-K. The effects of ionophore A23187 on erythrocytes relationship of ATP and 2,3-diphosphoglycerate to calcium-binding capacity 0005-2736 00052736 Elsevier |
| shingle_catch_all_2 | Edmondson, J.W. Li, T.-K. The effects of ionophore A23187 on erythrocytes relationship of ATP and 2,3-diphosphoglycerate to calcium-binding capacity 0005-2736 00052736 Elsevier |
| shingle_catch_all_3 | Edmondson, J.W. Li, T.-K. The effects of ionophore A23187 on erythrocytes relationship of ATP and 2,3-diphosphoglycerate to calcium-binding capacity 0005-2736 00052736 Elsevier |
| shingle_catch_all_4 | Edmondson, J.W. Li, T.-K. The effects of ionophore A23187 on erythrocytes relationship of ATP and 2,3-diphosphoglycerate to calcium-binding capacity 0005-2736 00052736 Elsevier |
| shingle_title_1 | The effects of ionophore A23187 on erythrocytes relationship of ATP and 2,3-diphosphoglycerate to calcium-binding capacity |
| shingle_title_2 | The effects of ionophore A23187 on erythrocytes relationship of ATP and 2,3-diphosphoglycerate to calcium-binding capacity |
| shingle_title_3 | The effects of ionophore A23187 on erythrocytes relationship of ATP and 2,3-diphosphoglycerate to calcium-binding capacity |
| shingle_title_4 | The effects of ionophore A23187 on erythrocytes relationship of ATP and 2,3-diphosphoglycerate to calcium-binding capacity |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:44:52.948Z |
| titel | The effects of ionophore A23187 on erythrocytes relationship of ATP and 2,3-diphosphoglycerate to calcium-binding capacity |
| titel_suche | The effects of ionophore A23187 on erythrocytes relationship of ATP and 2,3-diphosphoglycerate to calcium-binding capacity The divalent cation ionophore, A23187, was employed as a means to load fresh human erythrocytes with calcium, and the capacity for accumulation was characterized. Erythrocytes exposed to A23187 in calcium-containing media rapidly accumulated calcium in millimolar quantities. The final cellular concentration was dependent upon medium calcium concentration and the size of the cellular organophosphate pool. When ATP and 2,3-diphosphoglycerate contents were depleted or repleted, the cellular calcium content changed proportionally. Calcium loading of fresh erythrocytes produced no discernible change in the cellular concentrations of ATP or 2,3-diphosphoglycerate. Calcium accumulation was also accompanied by loss of cellular potassium and H"2O, deterioration of cell filterability, and spheroechinocytic transformation. |
| topic | W V WW-YZ U |
| uid | nat_lic_papers_NLZ187664544 |