Effects of 9-ene-tetrahydrocannabinol on uterine estrogenicity in the mouse
| ISSN: |
0960-0760
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|---|---|
| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
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| Topics: |
Biology
Chemistry and Pharmacology
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798292136007827456 |
|---|---|
| autor | Paria, B.C. Kapur, S. Dey, S.K. |
| autorsonst | Paria, B.C. Kapur, S. Dey, S.K. |
| book_url | http://linkinghub.elsevier.com/retrieve/pii/0960-0760(92)90112-V |
| datenlieferant | nat_lic_papers |
| fussnote | Several early (Phase I) and late (Phase II) estrogenic effects of 9-ene-tetrahydrocannabinol (THC) were examined in the adult mouse uterus. An injection of THC (2.5 or 10 mg/kg body wt) in ovariectomized mice neither stimulated uterine water imbibition or accumulation of [^1^2^5I]bovine serum albumin (Phase I responses) at 6 h, nor antagonized these Phase I responses elicited by estradiol-17β (E"2). With respect to Phase II responses, although single injections of THC (2.5, 5.0 and 10 mg/kg body wt) alone were ineffective in influencing uterine weight at 24 h or incorporation of [^3H]thymidine at 18 h, this drug interfered with these responses elicited by E"2 in a dose-dependent manner. In contrast, an injection of THC in progesterone (P"4)-primed ovariectomized mice modestly enhanced (61%) uterine incorporation of [^3H]thymidine. However, E"2-stimulated uterine thymidine incorporation in P"4-primed ovariectomized mice was antagonized by THC treatment. Effects of THC on blastocyst implantation were examined. Single or multiple injections of various doses of THC neither induced implantation in P"4-primed delayed implanting mice, nor interfered with E"2-induced implantation. Furthermore, daily injections of THC (10 mg/kg body wt) during the periimplantation period had no apparent adverse effects on implantation, or on experimentally induced decidualization (deciduomata). The data suggest that THC is neither pro- nor antiestrogenic with respect to Phase I responses. However as regards Phase II responses, THC is modestly proestrogenic in the P"4-treated uterus, but is antiestrogenic in the presence of E"2. These estrogen agonistic/antagonistic effects of THC on uterine Phase II responses do not adversely affect the process of implantation and decidualization. |
| hauptsatz | hsatz_simple |
| identnr | NLZ187417393 |
| issn | 0960-0760 |
| journal_name | The @Journal of Steroid Biochemistry and Molecular Biology |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 42 (1992), S. 713-719 |
| search_space | articles |
| shingle_author_1 | Paria, B.C. Kapur, S. Dey, S.K. |
| shingle_author_2 | Paria, B.C. Kapur, S. Dey, S.K. |
| shingle_author_3 | Paria, B.C. Kapur, S. Dey, S.K. |
| shingle_author_4 | Paria, B.C. Kapur, S. Dey, S.K. |
| shingle_catch_all_1 | Paria, B.C. Kapur, S. Dey, S.K. Effects of 9-ene-tetrahydrocannabinol on uterine estrogenicity in the mouse 0960-0760 09600760 Elsevier |
| shingle_catch_all_2 | Paria, B.C. Kapur, S. Dey, S.K. Effects of 9-ene-tetrahydrocannabinol on uterine estrogenicity in the mouse 0960-0760 09600760 Elsevier |
| shingle_catch_all_3 | Paria, B.C. Kapur, S. Dey, S.K. Effects of 9-ene-tetrahydrocannabinol on uterine estrogenicity in the mouse 0960-0760 09600760 Elsevier |
| shingle_catch_all_4 | Paria, B.C. Kapur, S. Dey, S.K. Effects of 9-ene-tetrahydrocannabinol on uterine estrogenicity in the mouse 0960-0760 09600760 Elsevier |
| shingle_title_1 | Effects of 9-ene-tetrahydrocannabinol on uterine estrogenicity in the mouse |
| shingle_title_2 | Effects of 9-ene-tetrahydrocannabinol on uterine estrogenicity in the mouse |
| shingle_title_3 | Effects of 9-ene-tetrahydrocannabinol on uterine estrogenicity in the mouse |
| shingle_title_4 | Effects of 9-ene-tetrahydrocannabinol on uterine estrogenicity in the mouse |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:43:43.239Z |
| titel | Effects of 9-ene-tetrahydrocannabinol on uterine estrogenicity in the mouse |
| titel_suche | Effects of 9-ene-tetrahydrocannabinol on uterine estrogenicity in the mouse Several early (Phase I) and late (Phase II) estrogenic effects of 9-ene-tetrahydrocannabinol (THC) were examined in the adult mouse uterus. An injection of THC (2.5 or 10 mg/kg body wt) in ovariectomized mice neither stimulated uterine water imbibition or accumulation of [^1^2^5I]bovine serum albumin (Phase I responses) at 6 h, nor antagonized these Phase I responses elicited by estradiol-17β (E"2). With respect to Phase II responses, although single injections of THC (2.5, 5.0 and 10 mg/kg body wt) alone were ineffective in influencing uterine weight at 24 h or incorporation of [^3H]thymidine at 18 h, this drug interfered with these responses elicited by E"2 in a dose-dependent manner. In contrast, an injection of THC in progesterone (P"4)-primed ovariectomized mice modestly enhanced (61%) uterine incorporation of [^3H]thymidine. However, E"2-stimulated uterine thymidine incorporation in P"4-primed ovariectomized mice was antagonized by THC treatment. Effects of THC on blastocyst implantation were examined. Single or multiple injections of various doses of THC neither induced implantation in P"4-primed delayed implanting mice, nor interfered with E"2-induced implantation. Furthermore, daily injections of THC (10 mg/kg body wt) during the periimplantation period had no apparent adverse effects on implantation, or on experimentally induced decidualization (deciduomata). The data suggest that THC is neither pro- nor antiestrogenic with respect to Phase I responses. However as regards Phase II responses, THC is modestly proestrogenic in the P"4-treated uterus, but is antiestrogenic in the presence of E"2. These estrogen agonistic/antagonistic effects of THC on uterine Phase II responses do not adversely affect the process of implantation and decidualization. |
| topic | W V |
| uid | nat_lic_papers_NLZ187417393 |