Influence of age and sex on basal secretion of growth hormone (GH) and on GH-induced release by porcine GH-releasing factor pGRF(1-29NH"2) in growing pigs
Dubreuil, P. ; Pelletier, G. ; Petitclerc, D. ; Lapierre, H. ; Couture, Y. ; Brazeau, P. ; Gaudreau, P. ; Morisset, J.
Amsterdam : Elsevier
Amsterdam : Elsevier
| ISSN: |
0739-7240
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|---|---|
| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
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| Topics: |
Medicine
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798292072685371392 |
|---|---|
| autor | Dubreuil, P. Pelletier, G. Petitclerc, D. Lapierre, H. Couture, Y. Brazeau, P. Gaudreau, P. Morisset, J. |
| autorsonst | Dubreuil, P. Pelletier, G. Petitclerc, D. Lapierre, H. Couture, Y. Brazeau, P. Gaudreau, P. Morisset, J. |
| book_url | http://linkinghub.elsevier.com/retrieve/pii/0739-7240(87)90026-9 |
| datenlieferant | nat_lic_papers |
| fussnote | The aim of this study was to determine the effect of age and sex on basal secretory patterns of growth hormone (GH) and growth hormone-releasing factor (GRF) induced GH release. Eighteen pigs (9 castrated males and 9 females) were stimulated with pGRF(1-29)NH"2 at 7,11,15,19 and 23 weeks of age. Blood samples were taken from each animal via jugular vein cannulate every 20 min, from 6 hr before to 5 hr after iv GRF administration at a dose of 4 μg/kg. GH baseline levels, amplitude of the GH peaks, area under the GH peaks and the overall mean of GH serum levels decreased (P〈.001) with age in both sexes. Age also had a marked effect on GRF-induced GH release: the amplitude of GH peaks and area under the GH peaks decreased (P〈.001) with age. The GH response to pGRF(1-29)NH"2 varied considerably, depending on the timing of the episodic endogenous secretion of GH. An immediate response (〈30 min) was observed when GRF was injected at the end of a trough period or at the beginning of a peak, but there was no immediate response when GRF was injected at the end of a peak or at the beginning of a trough period. Our results show that both endogenous GH secretion and pGRF(1-29)NH"2-induced GH release declines with age, suggesting a decreased sensitivity of the somatotroph cells to GRF with age; and that the high variability of the GH response to pGRF(1-29)NH"2 stimulation depends greatly on the timing of the episodic endogenous GH release, thus implying a possible episodic endogenous somatostatin secretion by the hypothalamus. |
| hauptsatz | hsatz_simple |
| identnr | NLZ187364230 |
| issn | 0739-7240 |
| journal_name | Domestic Animal Endocrinology |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 4 (1987), S. 299-307 |
| search_space | articles |
| shingle_author_1 | Dubreuil, P. Pelletier, G. Petitclerc, D. Lapierre, H. Couture, Y. Brazeau, P. Gaudreau, P. Morisset, J. |
| shingle_author_2 | Dubreuil, P. Pelletier, G. Petitclerc, D. Lapierre, H. Couture, Y. Brazeau, P. Gaudreau, P. Morisset, J. |
| shingle_author_3 | Dubreuil, P. Pelletier, G. Petitclerc, D. Lapierre, H. Couture, Y. Brazeau, P. Gaudreau, P. Morisset, J. |
| shingle_author_4 | Dubreuil, P. Pelletier, G. Petitclerc, D. Lapierre, H. Couture, Y. Brazeau, P. Gaudreau, P. Morisset, J. |
| shingle_catch_all_1 | Dubreuil, P. Pelletier, G. Petitclerc, D. Lapierre, H. Couture, Y. Brazeau, P. Gaudreau, P. Morisset, J. Influence of age and sex on basal secretion of growth hormone (GH) and on GH-induced release by porcine GH-releasing factor pGRF(1-29NH"2) in growing pigs 0739-7240 07397240 Elsevier |
| shingle_catch_all_2 | Dubreuil, P. Pelletier, G. Petitclerc, D. Lapierre, H. Couture, Y. Brazeau, P. Gaudreau, P. Morisset, J. Influence of age and sex on basal secretion of growth hormone (GH) and on GH-induced release by porcine GH-releasing factor pGRF(1-29NH"2) in growing pigs 0739-7240 07397240 Elsevier |
| shingle_catch_all_3 | Dubreuil, P. Pelletier, G. Petitclerc, D. Lapierre, H. Couture, Y. Brazeau, P. Gaudreau, P. Morisset, J. Influence of age and sex on basal secretion of growth hormone (GH) and on GH-induced release by porcine GH-releasing factor pGRF(1-29NH"2) in growing pigs 0739-7240 07397240 Elsevier |
| shingle_catch_all_4 | Dubreuil, P. Pelletier, G. Petitclerc, D. Lapierre, H. Couture, Y. Brazeau, P. Gaudreau, P. Morisset, J. Influence of age and sex on basal secretion of growth hormone (GH) and on GH-induced release by porcine GH-releasing factor pGRF(1-29NH"2) in growing pigs 0739-7240 07397240 Elsevier |
| shingle_title_1 | Influence of age and sex on basal secretion of growth hormone (GH) and on GH-induced release by porcine GH-releasing factor pGRF(1-29NH"2) in growing pigs |
| shingle_title_2 | Influence of age and sex on basal secretion of growth hormone (GH) and on GH-induced release by porcine GH-releasing factor pGRF(1-29NH"2) in growing pigs |
| shingle_title_3 | Influence of age and sex on basal secretion of growth hormone (GH) and on GH-induced release by porcine GH-releasing factor pGRF(1-29NH"2) in growing pigs |
| shingle_title_4 | Influence of age and sex on basal secretion of growth hormone (GH) and on GH-induced release by porcine GH-releasing factor pGRF(1-29NH"2) in growing pigs |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:42:42.688Z |
| titel | Influence of age and sex on basal secretion of growth hormone (GH) and on GH-induced release by porcine GH-releasing factor pGRF(1-29NH"2) in growing pigs |
| titel_suche | Influence of age and sex on basal secretion of growth hormone (GH) and on GH-induced release by porcine GH-releasing factor pGRF(1-29NH"2) in growing pigs The aim of this study was to determine the effect of age and sex on basal secretory patterns of growth hormone (GH) and growth hormone-releasing factor (GRF) induced GH release. Eighteen pigs (9 castrated males and 9 females) were stimulated with pGRF(1-29)NH"2 at 7,11,15,19 and 23 weeks of age. Blood samples were taken from each animal via jugular vein cannulate every 20 min, from 6 hr before to 5 hr after iv GRF administration at a dose of 4 μg/kg. GH baseline levels, amplitude of the GH peaks, area under the GH peaks and the overall mean of GH serum levels decreased (P〈.001) with age in both sexes. Age also had a marked effect on GRF-induced GH release: the amplitude of GH peaks and area under the GH peaks decreased (P〈.001) with age. The GH response to pGRF(1-29)NH"2 varied considerably, depending on the timing of the episodic endogenous secretion of GH. An immediate response (〈30 min) was observed when GRF was injected at the end of a trough period or at the beginning of a peak, but there was no immediate response when GRF was injected at the end of a peak or at the beginning of a trough period. Our results show that both endogenous GH secretion and pGRF(1-29)NH"2-induced GH release declines with age, suggesting a decreased sensitivity of the somatotroph cells to GRF with age; and that the high variability of the GH response to pGRF(1-29)NH"2 stimulation depends greatly on the timing of the episodic endogenous GH release, thus implying a possible episodic endogenous somatostatin secretion by the hypothalamus. |
| topic | WW-YZ |
| uid | nat_lic_papers_NLZ187364230 |