Dependence of tissue histamine content on local histidine decarboxylase activity
| ISSN: |
0304-4165
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|---|---|
| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
|
| Topics: |
Biology
Chemistry and Pharmacology
Medicine
Physics
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798291823958949888 |
|---|---|
| autor | Tredway Graham, H. Hannegan, T.W. Muller Nourse, C. |
| autorsonst | Tredway Graham, H. Hannegan, T.W. Muller Nourse, C. |
| book_url | http://linkinghub.elsevier.com/retrieve/pii/0304-4165(56)90283-5 |
| datenlieferant | nat_lic_papers |
| fussnote | 1. The histidine decarboxylase activity of mammalian tissues has been estimated by measuring the increase in histamine content of tissue homogenates during incubation in a histidine-containing solution. The incubation was carried out at pH 9.2 in the presence of a strong reducing agent to prevent histaminase activity. The histidine decarboxylase activity so measured varied over a hundred-fold range in the tissues investigated.2. The histidine decarboxylase activity of tissues varied in general in proportion to the histamine content of the tissues. Since there is strong evidence that histamine is localized almost exclusively in mast cells, these are probably also the locus of histidine decarboxylase.3. The distribution of histaminase activity was found not to be related either directly or inversely to the histamine content of tissues.4. The amount of combined histamine in the tissues was less than the amount of free histamine and bore little relation to the amount of combined histamine produced during incubation with histidine. |
| hauptsatz | hsatz_simple |
| identnr | NLZ187119848 |
| issn | 0304-4165 |
| journal_name | Biochimica et Biophysica Acta (BBA)/General Subjects |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 20 (1956), S. 243-250 |
| search_space | articles |
| shingle_author_1 | Tredway Graham, H. Hannegan, T.W. Muller Nourse, C. |
| shingle_author_2 | Tredway Graham, H. Hannegan, T.W. Muller Nourse, C. |
| shingle_author_3 | Tredway Graham, H. Hannegan, T.W. Muller Nourse, C. |
| shingle_author_4 | Tredway Graham, H. Hannegan, T.W. Muller Nourse, C. |
| shingle_catch_all_1 | Tredway Graham, H. Hannegan, T.W. Muller Nourse, C. Dependence of tissue histamine content on local histidine decarboxylase activity 0304-4165 03044165 Elsevier |
| shingle_catch_all_2 | Tredway Graham, H. Hannegan, T.W. Muller Nourse, C. Dependence of tissue histamine content on local histidine decarboxylase activity 0304-4165 03044165 Elsevier |
| shingle_catch_all_3 | Tredway Graham, H. Hannegan, T.W. Muller Nourse, C. Dependence of tissue histamine content on local histidine decarboxylase activity 0304-4165 03044165 Elsevier |
| shingle_catch_all_4 | Tredway Graham, H. Hannegan, T.W. Muller Nourse, C. Dependence of tissue histamine content on local histidine decarboxylase activity 0304-4165 03044165 Elsevier |
| shingle_title_1 | Dependence of tissue histamine content on local histidine decarboxylase activity |
| shingle_title_2 | Dependence of tissue histamine content on local histidine decarboxylase activity |
| shingle_title_3 | Dependence of tissue histamine content on local histidine decarboxylase activity |
| shingle_title_4 | Dependence of tissue histamine content on local histidine decarboxylase activity |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:38:45.854Z |
| titel | Dependence of tissue histamine content on local histidine decarboxylase activity |
| titel_suche | Dependence of tissue histamine content on local histidine decarboxylase activity 1. The histidine decarboxylase activity of mammalian tissues has been estimated by measuring the increase in histamine content of tissue homogenates during incubation in a histidine-containing solution. The incubation was carried out at pH 9.2 in the presence of a strong reducing agent to prevent histaminase activity. The histidine decarboxylase activity so measured varied over a hundred-fold range in the tissues investigated.2. The histidine decarboxylase activity of tissues varied in general in proportion to the histamine content of the tissues. Since there is strong evidence that histamine is localized almost exclusively in mast cells, these are probably also the locus of histidine decarboxylase.3. The distribution of histaminase activity was found not to be related either directly or inversely to the histamine content of tissues.4. The amount of combined histamine in the tissues was less than the amount of free histamine and bore little relation to the amount of combined histamine produced during incubation with histidine. |
| topic | W V WW-YZ U |
| uid | nat_lic_papers_NLZ187119848 |