High concentrations of arachidonic acid induce platelet aggregation and serotonin release independent of prostagladin endoperoxides and thromboxane A"2
Hashimoto, Y. ; Naito, C. ; Kume, S. ; Kato, H. ; Watanabe, T. ; Kawamura, M. ; Teramoto, T. ; Oka, H.
Amsterdam : Elsevier
Amsterdam : Elsevier
| ISSN: |
0304-4165
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|---|---|
| Keywords: |
Arachidonic acid ; Platelet aggregation ; Prostaglandin endoperoxide ; Serotonin release ; Thromboxane A"2
|
| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
|
| Topics: |
Biology
Chemistry and Pharmacology
Medicine
Physics
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798291820647546881 |
|---|---|
| autor | Hashimoto, Y. Naito, C. Kume, S. Kato, H. Watanabe, T. Kawamura, M. Teramoto, T. Oka, H. |
| autorsonst | Hashimoto, Y. Naito, C. Kume, S. Kato, H. Watanabe, T. Kawamura, M. Teramoto, T. Oka, H. |
| book_url | http://linkinghub.elsevier.com/retrieve/pii/0304-4165(85)90070-4 |
| datenlieferant | nat_lic_papers |
| fussnote | We examined platelet aggregation and serotonin release, induced by less than 60 μM arachidonic acid, using washed platelet suspensions in the absense of albumin. The concentration of arachidonic acid use did not cause platelet lysis. Platelet responses induced by less than 20 μM arachidonic acid were inhibited by aspirin, whereas those induced by above 30 μM arachidonic acid were not inhibited, even by both aspirin and 5,8,11,14-eicosatetraynoic acid. Although phosphatidic acid and 1,2-diacylglcerol increased after the addition of arachidonic acid in aspirin-treated platelets, the amounts were not parallel to platelet aggregation. Oleic, linoleic and linolenic acids also induced platelet responses, while palmitic, stearic and arachidic acids did not. EDTA, dibutyryl cyclic AMP, apyrase and creatine phosphate / creatin phosphokinase brought about almost the same effects in platelet responses induced by the unsaturated fatty acids, other than arachodinic acid, as those induced by 40 μM arachodonic acid. These results suggest that the mechanism of the actions of more than 30 μM arachodinic acid on platelets is the same as that of the other unsaturated fatty acids and is independent of prostaglandin endoperoxides, thromboxane A"2 and, perhaps, phosphatidic acid and 1,2-diacylglycerol. |
| hauptsatz | hsatz_simple |
| identnr | NLZ187088764 |
| issn | 0304-4165 |
| journal_name | Biochimica et Biophysica Acta (BBA)/General Subjects |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 841 (1985), S. 283-291 |
| schlagwort | Arachidonic acid Platelet aggregation Prostaglandin endoperoxide Serotonin release Thromboxane A"2 |
| search_space | articles |
| shingle_author_1 | Hashimoto, Y. Naito, C. Kume, S. Kato, H. Watanabe, T. Kawamura, M. Teramoto, T. Oka, H. |
| shingle_author_2 | Hashimoto, Y. Naito, C. Kume, S. Kato, H. Watanabe, T. Kawamura, M. Teramoto, T. Oka, H. |
| shingle_author_3 | Hashimoto, Y. Naito, C. Kume, S. Kato, H. Watanabe, T. Kawamura, M. Teramoto, T. Oka, H. |
| shingle_author_4 | Hashimoto, Y. Naito, C. Kume, S. Kato, H. Watanabe, T. Kawamura, M. Teramoto, T. Oka, H. |
| shingle_catch_all_1 | Hashimoto, Y. Naito, C. Kume, S. Kato, H. Watanabe, T. Kawamura, M. Teramoto, T. Oka, H. High concentrations of arachidonic acid induce platelet aggregation and serotonin release independent of prostagladin endoperoxides and thromboxane A"2 Arachidonic acid Platelet aggregation Prostaglandin endoperoxide Serotonin release Thromboxane A"2 Arachidonic acid Platelet aggregation Prostaglandin endoperoxide Serotonin release Thromboxane A"2 0304-4165 03044165 Elsevier |
| shingle_catch_all_2 | Hashimoto, Y. Naito, C. Kume, S. Kato, H. Watanabe, T. Kawamura, M. Teramoto, T. Oka, H. High concentrations of arachidonic acid induce platelet aggregation and serotonin release independent of prostagladin endoperoxides and thromboxane A"2 Arachidonic acid Platelet aggregation Prostaglandin endoperoxide Serotonin release Thromboxane A"2 Arachidonic acid Platelet aggregation Prostaglandin endoperoxide Serotonin release Thromboxane A"2 0304-4165 03044165 Elsevier |
| shingle_catch_all_3 | Hashimoto, Y. Naito, C. Kume, S. Kato, H. Watanabe, T. Kawamura, M. Teramoto, T. Oka, H. High concentrations of arachidonic acid induce platelet aggregation and serotonin release independent of prostagladin endoperoxides and thromboxane A"2 Arachidonic acid Platelet aggregation Prostaglandin endoperoxide Serotonin release Thromboxane A"2 Arachidonic acid Platelet aggregation Prostaglandin endoperoxide Serotonin release Thromboxane A"2 0304-4165 03044165 Elsevier |
| shingle_catch_all_4 | Hashimoto, Y. Naito, C. Kume, S. Kato, H. Watanabe, T. Kawamura, M. Teramoto, T. Oka, H. High concentrations of arachidonic acid induce platelet aggregation and serotonin release independent of prostagladin endoperoxides and thromboxane A"2 Arachidonic acid Platelet aggregation Prostaglandin endoperoxide Serotonin release Thromboxane A"2 Arachidonic acid Platelet aggregation Prostaglandin endoperoxide Serotonin release Thromboxane A"2 0304-4165 03044165 Elsevier |
| shingle_title_1 | High concentrations of arachidonic acid induce platelet aggregation and serotonin release independent of prostagladin endoperoxides and thromboxane A"2 |
| shingle_title_2 | High concentrations of arachidonic acid induce platelet aggregation and serotonin release independent of prostagladin endoperoxides and thromboxane A"2 |
| shingle_title_3 | High concentrations of arachidonic acid induce platelet aggregation and serotonin release independent of prostagladin endoperoxides and thromboxane A"2 |
| shingle_title_4 | High concentrations of arachidonic acid induce platelet aggregation and serotonin release independent of prostagladin endoperoxides and thromboxane A"2 |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:38:41.923Z |
| titel | High concentrations of arachidonic acid induce platelet aggregation and serotonin release independent of prostagladin endoperoxides and thromboxane A"2 |
| titel_suche | High concentrations of arachidonic acid induce platelet aggregation and serotonin release independent of prostagladin endoperoxides and thromboxane A"2 We examined platelet aggregation and serotonin release, induced by less than 60 μM arachidonic acid, using washed platelet suspensions in the absense of albumin. The concentration of arachidonic acid use did not cause platelet lysis. Platelet responses induced by less than 20 μM arachidonic acid were inhibited by aspirin, whereas those induced by above 30 μM arachidonic acid were not inhibited, even by both aspirin and 5,8,11,14-eicosatetraynoic acid. Although phosphatidic acid and 1,2-diacylglcerol increased after the addition of arachidonic acid in aspirin-treated platelets, the amounts were not parallel to platelet aggregation. Oleic, linoleic and linolenic acids also induced platelet responses, while palmitic, stearic and arachidic acids did not. EDTA, dibutyryl cyclic AMP, apyrase and creatine phosphate / creatin phosphokinase brought about almost the same effects in platelet responses induced by the unsaturated fatty acids, other than arachodinic acid, as those induced by 40 μM arachodonic acid. These results suggest that the mechanism of the actions of more than 30 μM arachodinic acid on platelets is the same as that of the other unsaturated fatty acids and is independent of prostaglandin endoperoxides, thromboxane A"2 and, perhaps, phosphatidic acid and 1,2-diacylglycerol. |
| topic | W V WW-YZ U |
| uid | nat_lic_papers_NLZ187088764 |