In vivo conversion of vasopressin after microinjection into limbic brain areas of rats
| ISSN: |
0196-9781
|
|---|---|
| Keywords: |
Aminopeptidase ; Brain microinjection ; In vivo metabolism ; Neuropeptides ; Vasopressin ; Vasopressin fragments
|
| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
|
| Topics: |
Chemistry and Pharmacology
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798291720586133504 |
|---|---|
| autor | Stark, H. Burbach, J.P.H. Van Der Kleij, A.A.M. De Wied, D. |
| autorsonst | Stark, H. Burbach, J.P.H. Van Der Kleij, A.A.M. De Wied, D. |
| book_url | http://linkinghub.elsevier.com/retrieve/pii/0196-9781(89)90102-2 |
| datenlieferant | nat_lic_papers |
| fussnote | The nonapeptide [Arg^8]vasopressin was rapidly degraded with a half-life of lower than 1 minute after local administration into the hippocampus. During the conversion of vasopressin C-terminal fragments were transiently generated. The profile of these metabolites indicated that they were formed by aminopeptidase activity. The aminopeptidase inhibitor amastatin partially inhibited the conversion of vasopressin. A minor pathway involved cleavages in the C-terminus. The results indicate a predominant involvement of aminopeptidase activity in the in vivo metabolism of exogenous vasopressin in the brain. Since products of this metabolic route have been shown to have potent behavioral activities, the behavioral effects seen after microinjection of vasopressin in the brain may be partially due to generation of vasopressin fragments. |
| hauptsatz | hsatz_simple |
| identnr | NLZ187005397 |
| issn | 0196-9781 |
| journal_name | Peptides |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 10 (1989), S. 717-720 |
| schlagwort | Aminopeptidase Brain microinjection In vivo metabolism Neuropeptides Vasopressin Vasopressin fragments |
| search_space | articles |
| shingle_author_1 | Stark, H. Burbach, J.P.H. Van Der Kleij, A.A.M. De Wied, D. |
| shingle_author_2 | Stark, H. Burbach, J.P.H. Van Der Kleij, A.A.M. De Wied, D. |
| shingle_author_3 | Stark, H. Burbach, J.P.H. Van Der Kleij, A.A.M. De Wied, D. |
| shingle_author_4 | Stark, H. Burbach, J.P.H. Van Der Kleij, A.A.M. De Wied, D. |
| shingle_catch_all_1 | Stark, H. Burbach, J.P.H. Van Der Kleij, A.A.M. De Wied, D. In vivo conversion of vasopressin after microinjection into limbic brain areas of rats Aminopeptidase Brain microinjection In vivo metabolism Neuropeptides Vasopressin Vasopressin fragments Aminopeptidase Brain microinjection In vivo metabolism Neuropeptides Vasopressin Vasopressin fragments 0196-9781 01969781 Elsevier |
| shingle_catch_all_2 | Stark, H. Burbach, J.P.H. Van Der Kleij, A.A.M. De Wied, D. In vivo conversion of vasopressin after microinjection into limbic brain areas of rats Aminopeptidase Brain microinjection In vivo metabolism Neuropeptides Vasopressin Vasopressin fragments Aminopeptidase Brain microinjection In vivo metabolism Neuropeptides Vasopressin Vasopressin fragments 0196-9781 01969781 Elsevier |
| shingle_catch_all_3 | Stark, H. Burbach, J.P.H. Van Der Kleij, A.A.M. De Wied, D. In vivo conversion of vasopressin after microinjection into limbic brain areas of rats Aminopeptidase Brain microinjection In vivo metabolism Neuropeptides Vasopressin Vasopressin fragments Aminopeptidase Brain microinjection In vivo metabolism Neuropeptides Vasopressin Vasopressin fragments 0196-9781 01969781 Elsevier |
| shingle_catch_all_4 | Stark, H. Burbach, J.P.H. Van Der Kleij, A.A.M. De Wied, D. In vivo conversion of vasopressin after microinjection into limbic brain areas of rats Aminopeptidase Brain microinjection In vivo metabolism Neuropeptides Vasopressin Vasopressin fragments Aminopeptidase Brain microinjection In vivo metabolism Neuropeptides Vasopressin Vasopressin fragments 0196-9781 01969781 Elsevier |
| shingle_title_1 | In vivo conversion of vasopressin after microinjection into limbic brain areas of rats |
| shingle_title_2 | In vivo conversion of vasopressin after microinjection into limbic brain areas of rats |
| shingle_title_3 | In vivo conversion of vasopressin after microinjection into limbic brain areas of rats |
| shingle_title_4 | In vivo conversion of vasopressin after microinjection into limbic brain areas of rats |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:37:06.382Z |
| titel | In vivo conversion of vasopressin after microinjection into limbic brain areas of rats |
| titel_suche | In vivo conversion of vasopressin after microinjection into limbic brain areas of rats The nonapeptide [Arg^8]vasopressin was rapidly degraded with a half-life of lower than 1 minute after local administration into the hippocampus. During the conversion of vasopressin C-terminal fragments were transiently generated. The profile of these metabolites indicated that they were formed by aminopeptidase activity. The aminopeptidase inhibitor amastatin partially inhibited the conversion of vasopressin. A minor pathway involved cleavages in the C-terminus. The results indicate a predominant involvement of aminopeptidase activity in the in vivo metabolism of exogenous vasopressin in the brain. Since products of this metabolic route have been shown to have potent behavioral activities, the behavioral effects seen after microinjection of vasopressin in the brain may be partially due to generation of vasopressin fragments. |
| topic | V |
| uid | nat_lic_papers_NLZ187005397 |