Molecular structure of the Cβ catalytic subunit of rat cAMP-dependent protein kinase and differential expression of Cα and Cβ isoforms in rat tissues and cultured cells
| ISSN: |
0167-4781
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| Keywords: |
(Mammalian cell and tissue) ; (Rat brain) ; Cβ catalytic subunit ; Expression ; cAMP-dependent protein kinase ; cDNA
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| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
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| Topics: |
Biology
Chemistry and Pharmacology
Medicine
Physics
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798292540121677824 |
|---|---|
| autor | Shuntoh, H. Sakamoto, N. Matsuyama, S. Saitoh, M. Tanaka, C. |
| autorsonst | Shuntoh, H. Sakamoto, N. Matsuyama, S. Saitoh, M. Tanaka, C. |
| book_url | http://linkinghub.elsevier.com/retrieve/pii/0167-4781(92)90073-9 |
| datenlieferant | nat_lic_papers |
| fussnote | A full-length cDNA clone encoding the Cβ catalytic subunit of cAMP-dependent protein kinase (PKA) was isolated from a rat brain cDNA library. A 1.1 kb cDNA containing the entire coding region encodes for a protein of 351 amino acids that shows more than 95% sequence homology to the Cβ subunits in mouse, bovine and human. Northern blot analysis showed distinct patterns of Cα and Cβ mRNA expression in the brain and various peripheral tissues. The Cα mRNA was widespread and highly expressed in brain, heart, adrenal gland, testis, lung, kidney, spleen and liver, whereas the Cβ mRNA was unevenly expressed in the brain and adrenal gland and in much lesser amounts in other tissues. The Cα mRNA was evenly distributed and highly expressed through various regions of the brain, while the Cβ mRNA was expressed in lesser amounts and was unevenly distributed. In neuronal and glial cultured cells, Cα mRNA was also predominantly expressed but Cβ mRNA was undetectable. The differential distribution between the C subunit isoforms of PKA suggests that individual subunits are involved in specialized functions. |
| hauptsatz | hsatz_simple |
| identnr | NLZ186811500 |
| issn | 0167-4781 |
| journal_name | Biochimica et Biophysica Acta (BBA)/Gene Structure and Expression |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 1131 (1992), S. 175-180 |
| schlagwort | (Mammalian cell and tissue) (Rat brain) Cβ catalytic subunit Expression cAMP-dependent protein kinase cDNA |
| search_space | articles |
| shingle_author_1 | Shuntoh, H. Sakamoto, N. Matsuyama, S. Saitoh, M. Tanaka, C. |
| shingle_author_2 | Shuntoh, H. Sakamoto, N. Matsuyama, S. Saitoh, M. Tanaka, C. |
| shingle_author_3 | Shuntoh, H. Sakamoto, N. Matsuyama, S. Saitoh, M. Tanaka, C. |
| shingle_author_4 | Shuntoh, H. Sakamoto, N. Matsuyama, S. Saitoh, M. Tanaka, C. |
| shingle_catch_all_1 | Shuntoh, H. Sakamoto, N. Matsuyama, S. Saitoh, M. Tanaka, C. Molecular structure of the Cβ catalytic subunit of rat cAMP-dependent protein kinase and differential expression of Cα and Cβ isoforms in rat tissues and cultured cells (Mammalian cell and tissue) (Rat brain) Cβ catalytic subunit Expression cAMP-dependent protein kinase cDNA (Mammalian cell and tissue) (Rat brain) Cβ catalytic subunit Expression cAMP-dependent protein kinase cDNA 0167-4781 01674781 Elsevier |
| shingle_catch_all_2 | Shuntoh, H. Sakamoto, N. Matsuyama, S. Saitoh, M. Tanaka, C. Molecular structure of the Cβ catalytic subunit of rat cAMP-dependent protein kinase and differential expression of Cα and Cβ isoforms in rat tissues and cultured cells (Mammalian cell and tissue) (Rat brain) Cβ catalytic subunit Expression cAMP-dependent protein kinase cDNA (Mammalian cell and tissue) (Rat brain) Cβ catalytic subunit Expression cAMP-dependent protein kinase cDNA 0167-4781 01674781 Elsevier |
| shingle_catch_all_3 | Shuntoh, H. Sakamoto, N. Matsuyama, S. Saitoh, M. Tanaka, C. Molecular structure of the Cβ catalytic subunit of rat cAMP-dependent protein kinase and differential expression of Cα and Cβ isoforms in rat tissues and cultured cells (Mammalian cell and tissue) (Rat brain) Cβ catalytic subunit Expression cAMP-dependent protein kinase cDNA (Mammalian cell and tissue) (Rat brain) Cβ catalytic subunit Expression cAMP-dependent protein kinase cDNA 0167-4781 01674781 Elsevier |
| shingle_catch_all_4 | Shuntoh, H. Sakamoto, N. Matsuyama, S. Saitoh, M. Tanaka, C. Molecular structure of the Cβ catalytic subunit of rat cAMP-dependent protein kinase and differential expression of Cα and Cβ isoforms in rat tissues and cultured cells (Mammalian cell and tissue) (Rat brain) Cβ catalytic subunit Expression cAMP-dependent protein kinase cDNA (Mammalian cell and tissue) (Rat brain) Cβ catalytic subunit Expression cAMP-dependent protein kinase cDNA 0167-4781 01674781 Elsevier |
| shingle_title_1 | Molecular structure of the Cβ catalytic subunit of rat cAMP-dependent protein kinase and differential expression of Cα and Cβ isoforms in rat tissues and cultured cells |
| shingle_title_2 | Molecular structure of the Cβ catalytic subunit of rat cAMP-dependent protein kinase and differential expression of Cα and Cβ isoforms in rat tissues and cultured cells |
| shingle_title_3 | Molecular structure of the Cβ catalytic subunit of rat cAMP-dependent protein kinase and differential expression of Cα and Cβ isoforms in rat tissues and cultured cells |
| shingle_title_4 | Molecular structure of the Cβ catalytic subunit of rat cAMP-dependent protein kinase and differential expression of Cα and Cβ isoforms in rat tissues and cultured cells |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:50:07.988Z |
| titel | Molecular structure of the Cβ catalytic subunit of rat cAMP-dependent protein kinase and differential expression of Cα and Cβ isoforms in rat tissues and cultured cells |
| titel_suche | Molecular structure of the Cβ catalytic subunit of rat cAMP-dependent protein kinase and differential expression of Cα and Cβ isoforms in rat tissues and cultured cells A full-length cDNA clone encoding the Cβ catalytic subunit of cAMP-dependent protein kinase (PKA) was isolated from a rat brain cDNA library. A 1.1 kb cDNA containing the entire coding region encodes for a protein of 351 amino acids that shows more than 95% sequence homology to the Cβ subunits in mouse, bovine and human. Northern blot analysis showed distinct patterns of Cα and Cβ mRNA expression in the brain and various peripheral tissues. The Cα mRNA was widespread and highly expressed in brain, heart, adrenal gland, testis, lung, kidney, spleen and liver, whereas the Cβ mRNA was unevenly expressed in the brain and adrenal gland and in much lesser amounts in other tissues. The Cα mRNA was evenly distributed and highly expressed through various regions of the brain, while the Cβ mRNA was expressed in lesser amounts and was unevenly distributed. In neuronal and glial cultured cells, Cα mRNA was also predominantly expressed but Cβ mRNA was undetectable. The differential distribution between the C subunit isoforms of PKA suggests that individual subunits are involved in specialized functions. |
| topic | W V WW-YZ U |
| uid | nat_lic_papers_NLZ186811500 |