Effect of somatocrinin and a somatostatin antiserum on duodenal and gastric growth in the rat
| ISSN: |
0167-0115
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|---|---|
| Keywords: |
gastrin and duodenum growth ; hyperplasia ; somatocrinin ; somatostatin antiserum
|
| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
|
| Topics: |
Medicine
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798291613358751746 |
|---|---|
| autor | Dubreuil, P. Morisset, J. |
| autorsonst | Dubreuil, P. Morisset, J. |
| book_url | http://linkinghub.elsevier.com/retrieve/pii/0167-0115(86)90194-1 |
| datenlieferant | nat_lic_papers |
| fussnote | This study examines the effects of somatocrinin (GRF) and somatostatin antiserum (ASS), jointly and separately on gastric and duodenal growth. 24-day-old rats received twice daily SC injections of saline or GRF (4 and 20 μg . kg^-^1) for 14 days. ASS was given IP every 2 days. Alone, GRF increased gastric fundus weight concomitantly with DNA, RNA and protein contents producing hyperplasia and hypertrophy within this gland. Alone, ASS increased RNA and protein cellular concentrations. Joint ASS and GRF treatment stabilized the weight and protein content of the fundus, while reducing RNA contents as well as RNA and protein concentrations. GRF alone caused significant increments in duodenal weight and protein content suggesting cellular hypertrophy. Growth hormone, gastrin, cholecystokinin and secretin may be considered as putative mediators of these trophic effects. |
| hauptsatz | hsatz_simple |
| identnr | NLZ186759266 |
| issn | 0167-0115 |
| journal_name | Regulatory Peptides |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 16 (1986), S. 51-67 |
| schlagwort | gastrin and duodenum growth hyperplasia somatocrinin somatostatin antiserum |
| search_space | articles |
| shingle_author_1 | Dubreuil, P. Morisset, J. |
| shingle_author_2 | Dubreuil, P. Morisset, J. |
| shingle_author_3 | Dubreuil, P. Morisset, J. |
| shingle_author_4 | Dubreuil, P. Morisset, J. |
| shingle_catch_all_1 | Dubreuil, P. Morisset, J. Effect of somatocrinin and a somatostatin antiserum on duodenal and gastric growth in the rat gastrin and duodenum growth hyperplasia somatocrinin somatostatin antiserum gastrin and duodenum growth hyperplasia somatocrinin somatostatin antiserum 0167-0115 01670115 Elsevier |
| shingle_catch_all_2 | Dubreuil, P. Morisset, J. Effect of somatocrinin and a somatostatin antiserum on duodenal and gastric growth in the rat gastrin and duodenum growth hyperplasia somatocrinin somatostatin antiserum gastrin and duodenum growth hyperplasia somatocrinin somatostatin antiserum 0167-0115 01670115 Elsevier |
| shingle_catch_all_3 | Dubreuil, P. Morisset, J. Effect of somatocrinin and a somatostatin antiserum on duodenal and gastric growth in the rat gastrin and duodenum growth hyperplasia somatocrinin somatostatin antiserum gastrin and duodenum growth hyperplasia somatocrinin somatostatin antiserum 0167-0115 01670115 Elsevier |
| shingle_catch_all_4 | Dubreuil, P. Morisset, J. Effect of somatocrinin and a somatostatin antiserum on duodenal and gastric growth in the rat gastrin and duodenum growth hyperplasia somatocrinin somatostatin antiserum gastrin and duodenum growth hyperplasia somatocrinin somatostatin antiserum 0167-0115 01670115 Elsevier |
| shingle_title_1 | Effect of somatocrinin and a somatostatin antiserum on duodenal and gastric growth in the rat |
| shingle_title_2 | Effect of somatocrinin and a somatostatin antiserum on duodenal and gastric growth in the rat |
| shingle_title_3 | Effect of somatocrinin and a somatostatin antiserum on duodenal and gastric growth in the rat |
| shingle_title_4 | Effect of somatocrinin and a somatostatin antiserum on duodenal and gastric growth in the rat |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:35:23.926Z |
| titel | Effect of somatocrinin and a somatostatin antiserum on duodenal and gastric growth in the rat |
| titel_suche | Effect of somatocrinin and a somatostatin antiserum on duodenal and gastric growth in the rat This study examines the effects of somatocrinin (GRF) and somatostatin antiserum (ASS), jointly and separately on gastric and duodenal growth. 24-day-old rats received twice daily SC injections of saline or GRF (4 and 20 μg . kg^-^1) for 14 days. ASS was given IP every 2 days. Alone, GRF increased gastric fundus weight concomitantly with DNA, RNA and protein contents producing hyperplasia and hypertrophy within this gland. Alone, ASS increased RNA and protein cellular concentrations. Joint ASS and GRF treatment stabilized the weight and protein content of the fundus, while reducing RNA contents as well as RNA and protein concentrations. GRF alone caused significant increments in duodenal weight and protein content suggesting cellular hypertrophy. Growth hormone, gastrin, cholecystokinin and secretin may be considered as putative mediators of these trophic effects. |
| topic | WW-YZ |
| uid | nat_lic_papers_NLZ186759266 |