Suppressing effects of human fetal cell extract on micronuclei induced by cyclophosphamide in mice
Chen, S.-q. ; Xue, K.-x. ; Ma, G.-j. ; Wu, J.-z. ; Wang, H. ; Xiang, L.-p. ; Cheng, N.
Amsterdam : Elsevier
Amsterdam : Elsevier
| ISSN: |
0027-5107
|
|---|---|
| Keywords: |
(Mice) ; Humasn fetal cell extract, Cyclophosphamide ; Micronucleus
|
| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
|
| Topics: |
Biology
Medicine
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798291136841777152 |
|---|---|
| autor | Chen, S.-q. Xue, K.-x. Ma, G.-j. Wu, J.-z. Wang, H. Xiang, L.-p. Cheng, N. |
| autorsonst | Chen, S.-q. Xue, K.-x. Ma, G.-j. Wu, J.-z. Wang, H. Xiang, L.-p. Cheng, N. |
| book_url | http://linkinghub.elsevier.com/retrieve/pii/0027-5107(94)90014-0 |
| datenlieferant | nat_lic_papers |
| fussnote | The genotoxicity of human fetal cell extract (HFCE) and its effect on the frequency of micronucleated polychromatic erythrocytes (PCE-MNF) in mice induced by cyclophosphamide (CP) were studied. Statistically significant differences were not foud between the control group and each group treated with HFCE (0.3, 3, 30 mg/kg bw). CP (200 mg/kg bw) induced a marked increase in MNF (P 〈 0.01). Administered together with CP, HFCE suppressed the increase of MNF induced by CP. The reduction effect is dependent on the dose of HFCE. At doses of 3 and 30 mg/kg bw HFCE, MNF decreased markedly (P 〈 0.05 and 〈 0/01, respectively). It showed that HFCE did not induced micronucleus formation, while it could suppress the micronucleus formation induced by CP in mice. The results suggested that HFCE might be antimutagenic and have potential value in clinical application. |
| hauptsatz | hsatz_simple |
| identnr | NLZ186504128 |
| issn | 0027-5107 |
| journal_name | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 310 (1994), S. 113-116 |
| schlagwort | (Mice) Humasn fetal cell extract, Cyclophosphamide Micronucleus |
| search_space | articles |
| shingle_author_1 | Chen, S.-q. Xue, K.-x. Ma, G.-j. Wu, J.-z. Wang, H. Xiang, L.-p. Cheng, N. |
| shingle_author_2 | Chen, S.-q. Xue, K.-x. Ma, G.-j. Wu, J.-z. Wang, H. Xiang, L.-p. Cheng, N. |
| shingle_author_3 | Chen, S.-q. Xue, K.-x. Ma, G.-j. Wu, J.-z. Wang, H. Xiang, L.-p. Cheng, N. |
| shingle_author_4 | Chen, S.-q. Xue, K.-x. Ma, G.-j. Wu, J.-z. Wang, H. Xiang, L.-p. Cheng, N. |
| shingle_catch_all_1 | Chen, S.-q. Xue, K.-x. Ma, G.-j. Wu, J.-z. Wang, H. Xiang, L.-p. Cheng, N. Suppressing effects of human fetal cell extract on micronuclei induced by cyclophosphamide in mice (Mice) Humasn fetal cell extract, Cyclophosphamide Micronucleus (Mice) Humasn fetal cell extract, Cyclophosphamide Micronucleus 0027-5107 00275107 Elsevier |
| shingle_catch_all_2 | Chen, S.-q. Xue, K.-x. Ma, G.-j. Wu, J.-z. Wang, H. Xiang, L.-p. Cheng, N. Suppressing effects of human fetal cell extract on micronuclei induced by cyclophosphamide in mice (Mice) Humasn fetal cell extract, Cyclophosphamide Micronucleus (Mice) Humasn fetal cell extract, Cyclophosphamide Micronucleus 0027-5107 00275107 Elsevier |
| shingle_catch_all_3 | Chen, S.-q. Xue, K.-x. Ma, G.-j. Wu, J.-z. Wang, H. Xiang, L.-p. Cheng, N. Suppressing effects of human fetal cell extract on micronuclei induced by cyclophosphamide in mice (Mice) Humasn fetal cell extract, Cyclophosphamide Micronucleus (Mice) Humasn fetal cell extract, Cyclophosphamide Micronucleus 0027-5107 00275107 Elsevier |
| shingle_catch_all_4 | Chen, S.-q. Xue, K.-x. Ma, G.-j. Wu, J.-z. Wang, H. Xiang, L.-p. Cheng, N. Suppressing effects of human fetal cell extract on micronuclei induced by cyclophosphamide in mice (Mice) Humasn fetal cell extract, Cyclophosphamide Micronucleus (Mice) Humasn fetal cell extract, Cyclophosphamide Micronucleus 0027-5107 00275107 Elsevier |
| shingle_title_1 | Suppressing effects of human fetal cell extract on micronuclei induced by cyclophosphamide in mice |
| shingle_title_2 | Suppressing effects of human fetal cell extract on micronuclei induced by cyclophosphamide in mice |
| shingle_title_3 | Suppressing effects of human fetal cell extract on micronuclei induced by cyclophosphamide in mice |
| shingle_title_4 | Suppressing effects of human fetal cell extract on micronuclei induced by cyclophosphamide in mice |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:27:50.212Z |
| titel | Suppressing effects of human fetal cell extract on micronuclei induced by cyclophosphamide in mice |
| titel_suche | Suppressing effects of human fetal cell extract on micronuclei induced by cyclophosphamide in mice The genotoxicity of human fetal cell extract (HFCE) and its effect on the frequency of micronucleated polychromatic erythrocytes (PCE-MNF) in mice induced by cyclophosphamide (CP) were studied. Statistically significant differences were not foud between the control group and each group treated with HFCE (0.3, 3, 30 mg/kg bw). CP (200 mg/kg bw) induced a marked increase in MNF (P 〈 0.01). Administered together with CP, HFCE suppressed the increase of MNF induced by CP. The reduction effect is dependent on the dose of HFCE. At doses of 3 and 30 mg/kg bw HFCE, MNF decreased markedly (P 〈 0.05 and 〈 0/01, respectively). It showed that HFCE did not induced micronucleus formation, while it could suppress the micronucleus formation induced by CP in mice. The results suggested that HFCE might be antimutagenic and have potential value in clinical application. |
| topic | W WW-YZ |
| uid | nat_lic_papers_NLZ186504128 |