Regulation of low density lipoprotein receptor activity by cultured human arterial smooth muscle cells
| ISSN: |
0005-2760
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|---|---|
| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
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| Topics: |
Biology
Chemistry and Pharmacology
Medicine
Physics
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798292218536001536 |
|---|---|
| autor | Bierman, E.L. Albers, J. |
| autorsonst | Bierman, E.L. Albers, J. |
| book_url | http://linkinghub.elsevier.com/retrieve/pii/0005-2760(77)90133-3 |
| datenlieferant | nat_lic_papers |
| fussnote | The ability of cultured human arterial smooth muscle cells to regulate low density lipoprotein (LDL) receptor activity was tested. In contrast to human skin fibroblasts incubated with lipoprotein deficient medium under identical conditions, smooth muscle cells showed significantly reduced enhancement of ^1^2^5I-labeled LDL and ^1^2^5I-labeled VLDL (very low density lipoprotein) binding. Smooth muscle cells also failed to suppress LDL receptor activity during incubation with either LDL or cholesterol added to the medium, while fibroblasts showed an active regulatory response. Thus, in comparison with the brisk LDL receptor regulation characteristic of skin fibroblasts, arterial smooth muscle cells have an attenuated capacity to regulate their LDL receptor activity. These results may be relevant to the propensity of these cells to accumulate LDL and cholesterol and form ''foam cells'' in the arterial wall in vivo, a process associated with atherogenesis. |
| hauptsatz | hsatz_simple |
| identnr | NLZ185957447 |
| issn | 0005-2760 |
| journal_name | Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 488 (1977), S. 152-160 |
| search_space | articles |
| shingle_author_1 | Bierman, E.L. Albers, J. |
| shingle_author_2 | Bierman, E.L. Albers, J. |
| shingle_author_3 | Bierman, E.L. Albers, J. |
| shingle_author_4 | Bierman, E.L. Albers, J. |
| shingle_catch_all_1 | Bierman, E.L. Albers, J. Regulation of low density lipoprotein receptor activity by cultured human arterial smooth muscle cells 0005-2760 00052760 Elsevier |
| shingle_catch_all_2 | Bierman, E.L. Albers, J. Regulation of low density lipoprotein receptor activity by cultured human arterial smooth muscle cells 0005-2760 00052760 Elsevier |
| shingle_catch_all_3 | Bierman, E.L. Albers, J. Regulation of low density lipoprotein receptor activity by cultured human arterial smooth muscle cells 0005-2760 00052760 Elsevier |
| shingle_catch_all_4 | Bierman, E.L. Albers, J. Regulation of low density lipoprotein receptor activity by cultured human arterial smooth muscle cells 0005-2760 00052760 Elsevier |
| shingle_title_1 | Regulation of low density lipoprotein receptor activity by cultured human arterial smooth muscle cells |
| shingle_title_2 | Regulation of low density lipoprotein receptor activity by cultured human arterial smooth muscle cells |
| shingle_title_3 | Regulation of low density lipoprotein receptor activity by cultured human arterial smooth muscle cells |
| shingle_title_4 | Regulation of low density lipoprotein receptor activity by cultured human arterial smooth muscle cells |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:45:01.428Z |
| titel | Regulation of low density lipoprotein receptor activity by cultured human arterial smooth muscle cells |
| titel_suche | Regulation of low density lipoprotein receptor activity by cultured human arterial smooth muscle cells The ability of cultured human arterial smooth muscle cells to regulate low density lipoprotein (LDL) receptor activity was tested. In contrast to human skin fibroblasts incubated with lipoprotein deficient medium under identical conditions, smooth muscle cells showed significantly reduced enhancement of ^1^2^5I-labeled LDL and ^1^2^5I-labeled VLDL (very low density lipoprotein) binding. Smooth muscle cells also failed to suppress LDL receptor activity during incubation with either LDL or cholesterol added to the medium, while fibroblasts showed an active regulatory response. Thus, in comparison with the brisk LDL receptor regulation characteristic of skin fibroblasts, arterial smooth muscle cells have an attenuated capacity to regulate their LDL receptor activity. These results may be relevant to the propensity of these cells to accumulate LDL and cholesterol and form ''foam cells'' in the arterial wall in vivo, a process associated with atherogenesis. |
| topic | W V WW-YZ U |
| uid | nat_lic_papers_NLZ185957447 |