Achatin-I, an endogenous neuroexcitatory tetrapeptide from achatina fulica ferussac containing A d-amino acid residue
Kamatani, Y. ; Minakata, H. ; Kenny, P.T.M. ; Iwashita, T. ; Watanabe, K. ; Funase, K. ; Xia Ping, S. ; Yongsiri, A. ; Kanapi, C.G. ; Novales, E.T. ; Takeuchi, H. ; Nomoto, K. ; Kim, K.H. ; Novales-Li, P.
Amsterdam : Elsevier
Amsterdam : Elsevier
| ISSN: |
0006-291X
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|---|---|
| Keywords: |
[abr] CD; circular dichroism ; [abr] ED"5"0; effective dose fifty ; [abr] FMRFamide; ; [abr] HPLC; high performance liquid chromatography ; [abr] PON; periodically oscillating neuron ; [abr] SIMS; secondary ionization mass spectrometry ; [abr] TAN; tonically autoactive neuron ; [abr] Tris; tris-(hyroxymethyl) aminomethane ; [abr] VG1; visceral ganglion neuron ; [abr] ^1H-NMR; proton nuclear magnetic resonance ; [abr] d-LCDN; dorsal left cerebral distinct neuron ; [abr] d-RCDN; dorsal right cerebral distinct neuron ; [abr] v-RCDN; ventral right cerebral distinct neuron
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| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
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| Topics: |
Biology
Chemistry and Pharmacology
Physics
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798292257897447425 |
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| autor | Kamatani, Y. Minakata, H. Kenny, P.T.M. Iwashita, T. Watanabe, K. Funase, K. Xia Ping, S. Yongsiri, A. Kanapi, C.G. Novales, E.T. Takeuchi, H. Nomoto, K. Kim, K.H. Novales-Li, P. |
| autorsonst | Kamatani, Y. Minakata, H. Kenny, P.T.M. Iwashita, T. Watanabe, K. Funase, K. Xia Ping, S. Yongsiri, A. Kanapi, C.G. Novales, E.T. Takeuchi, H. Nomoto, K. Kim, K.H. Novales-Li, P. |
| book_url | http://dx.doi.org/10.1016/S0006-291X(89)80103-2 |
| datenlieferant | nat_lic_papers |
| fussnote | A tetrapeptide named achatin-I was purified from the suboesophageal and cerebral ganglia of the African giant snail Achatina fulica Ferussac, and evoked a potent neuroexcitatory effect. The amino acid sequence of achatin-I is Gly-d-Phe-Ala-Asp. Achatin-I induced a voltage-dependent inward current, due to Na^+, on the identifiable giant neuron, periodically oscillating neuron (PON), of the same snail. All possible isomers of achatin-I were synthesized using the solid-phase method. The sensitivity of the neuron to achatin-I and its isomers was strictly stereospecific; among the various isomers, only achatin-I showed marked effects (ED"5"0=2.29x 10^-^6M), while Gly-d-Ala-Asp, the synthetic d-Ala-isomer, was less than 10^-^3 active. |
| hauptsatz | hsatz_simple |
| identnr | NLZ184947456 |
| issn | 0006-291X |
| journal_name | Biochemical and Biophysical Research Communications |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 160 (1989), S. 1015-1020 |
| schlagwort | [abr] CD; circular dichroism [abr] ED"5"0; effective dose fifty [abr] FMRFamide; [abr] HPLC; high performance liquid chromatography [abr] PON; periodically oscillating neuron [abr] SIMS; secondary ionization mass spectrometry [abr] TAN; tonically autoactive neuron [abr] Tris; tris-(hyroxymethyl) aminomethane [abr] VG1; visceral ganglion neuron [abr] ^1H-NMR; proton nuclear magnetic resonance [abr] d-LCDN; dorsal left cerebral distinct neuron [abr] d-RCDN; dorsal right cerebral distinct neuron [abr] v-RCDN; ventral right cerebral distinct neuron |
| search_space | articles |
| shingle_author_1 | Kamatani, Y. Minakata, H. Kenny, P.T.M. Iwashita, T. Watanabe, K. Funase, K. Xia Ping, S. Yongsiri, A. Kanapi, C.G. Novales, E.T. Takeuchi, H. Nomoto, K. Kim, K.H. Novales-Li, P. |
| shingle_author_2 | Kamatani, Y. Minakata, H. Kenny, P.T.M. Iwashita, T. Watanabe, K. Funase, K. Xia Ping, S. Yongsiri, A. Kanapi, C.G. Novales, E.T. Takeuchi, H. Nomoto, K. Kim, K.H. Novales-Li, P. |
| shingle_author_3 | Kamatani, Y. Minakata, H. Kenny, P.T.M. Iwashita, T. Watanabe, K. Funase, K. Xia Ping, S. Yongsiri, A. Kanapi, C.G. Novales, E.T. Takeuchi, H. Nomoto, K. Kim, K.H. Novales-Li, P. |
| shingle_author_4 | Kamatani, Y. Minakata, H. Kenny, P.T.M. Iwashita, T. Watanabe, K. Funase, K. Xia Ping, S. Yongsiri, A. Kanapi, C.G. Novales, E.T. Takeuchi, H. Nomoto, K. Kim, K.H. Novales-Li, P. |
| shingle_catch_all_1 | Kamatani, Y. Minakata, H. Kenny, P.T.M. Iwashita, T. Watanabe, K. Funase, K. Xia Ping, S. Yongsiri, A. Kanapi, C.G. Novales, E.T. Takeuchi, H. Nomoto, K. Kim, K.H. Novales-Li, P. Achatin-I, an endogenous neuroexcitatory tetrapeptide from achatina fulica ferussac containing A d-amino acid residue [abr] CD; circular dichroism [abr] ED"5"0; effective dose fifty [abr] FMRFamide; [abr] HPLC; high performance liquid chromatography [abr] PON; periodically oscillating neuron [abr] SIMS; secondary ionization mass spectrometry [abr] TAN; tonically autoactive neuron [abr] Tris; tris-(hyroxymethyl) aminomethane [abr] VG1; visceral ganglion neuron [abr] ^1H-NMR; proton nuclear magnetic resonance [abr] d-LCDN; dorsal left cerebral distinct neuron [abr] d-RCDN; dorsal right cerebral distinct neuron [abr] v-RCDN; ventral right cerebral distinct neuron [abr] CD; circular dichroism [abr] ED"5"0; effective dose fifty [abr] FMRFamide; [abr] HPLC; high performance liquid chromatography [abr] PON; periodically oscillating neuron [abr] SIMS; secondary ionization mass spectrometry [abr] TAN; tonically autoactive neuron [abr] Tris; tris-(hyroxymethyl) aminomethane [abr] VG1; visceral ganglion neuron [abr] ^1H-NMR; proton nuclear magnetic resonance [abr] d-LCDN; dorsal left cerebral distinct neuron [abr] d-RCDN; dorsal right cerebral distinct neuron [abr] v-RCDN; ventral right cerebral distinct neuron 0006-291X 0006291X Elsevier |
| shingle_catch_all_2 | Kamatani, Y. Minakata, H. Kenny, P.T.M. Iwashita, T. Watanabe, K. Funase, K. Xia Ping, S. Yongsiri, A. Kanapi, C.G. Novales, E.T. Takeuchi, H. Nomoto, K. Kim, K.H. Novales-Li, P. Achatin-I, an endogenous neuroexcitatory tetrapeptide from achatina fulica ferussac containing A d-amino acid residue [abr] CD; circular dichroism [abr] ED"5"0; effective dose fifty [abr] FMRFamide; [abr] HPLC; high performance liquid chromatography [abr] PON; periodically oscillating neuron [abr] SIMS; secondary ionization mass spectrometry [abr] TAN; tonically autoactive neuron [abr] Tris; tris-(hyroxymethyl) aminomethane [abr] VG1; visceral ganglion neuron [abr] ^1H-NMR; proton nuclear magnetic resonance [abr] d-LCDN; dorsal left cerebral distinct neuron [abr] d-RCDN; dorsal right cerebral distinct neuron [abr] v-RCDN; ventral right cerebral distinct neuron [abr] CD; circular dichroism [abr] ED"5"0; effective dose fifty [abr] FMRFamide; [abr] HPLC; high performance liquid chromatography [abr] PON; periodically oscillating neuron [abr] SIMS; secondary ionization mass spectrometry [abr] TAN; tonically autoactive neuron [abr] Tris; tris-(hyroxymethyl) aminomethane [abr] VG1; visceral ganglion neuron [abr] ^1H-NMR; proton nuclear magnetic resonance [abr] d-LCDN; dorsal left cerebral distinct neuron [abr] d-RCDN; dorsal right cerebral distinct neuron [abr] v-RCDN; ventral right cerebral distinct neuron 0006-291X 0006291X Elsevier |
| shingle_catch_all_3 | Kamatani, Y. Minakata, H. Kenny, P.T.M. Iwashita, T. Watanabe, K. Funase, K. Xia Ping, S. Yongsiri, A. Kanapi, C.G. Novales, E.T. Takeuchi, H. Nomoto, K. Kim, K.H. Novales-Li, P. Achatin-I, an endogenous neuroexcitatory tetrapeptide from achatina fulica ferussac containing A d-amino acid residue [abr] CD; circular dichroism [abr] ED"5"0; effective dose fifty [abr] FMRFamide; [abr] HPLC; high performance liquid chromatography [abr] PON; periodically oscillating neuron [abr] SIMS; secondary ionization mass spectrometry [abr] TAN; tonically autoactive neuron [abr] Tris; tris-(hyroxymethyl) aminomethane [abr] VG1; visceral ganglion neuron [abr] ^1H-NMR; proton nuclear magnetic resonance [abr] d-LCDN; dorsal left cerebral distinct neuron [abr] d-RCDN; dorsal right cerebral distinct neuron [abr] v-RCDN; ventral right cerebral distinct neuron [abr] CD; circular dichroism [abr] ED"5"0; effective dose fifty [abr] FMRFamide; [abr] HPLC; high performance liquid chromatography [abr] PON; periodically oscillating neuron [abr] SIMS; secondary ionization mass spectrometry [abr] TAN; tonically autoactive neuron [abr] Tris; tris-(hyroxymethyl) aminomethane [abr] VG1; visceral ganglion neuron [abr] ^1H-NMR; proton nuclear magnetic resonance [abr] d-LCDN; dorsal left cerebral distinct neuron [abr] d-RCDN; dorsal right cerebral distinct neuron [abr] v-RCDN; ventral right cerebral distinct neuron 0006-291X 0006291X Elsevier |
| shingle_catch_all_4 | Kamatani, Y. Minakata, H. Kenny, P.T.M. Iwashita, T. Watanabe, K. Funase, K. Xia Ping, S. Yongsiri, A. Kanapi, C.G. Novales, E.T. Takeuchi, H. Nomoto, K. Kim, K.H. Novales-Li, P. Achatin-I, an endogenous neuroexcitatory tetrapeptide from achatina fulica ferussac containing A d-amino acid residue [abr] CD; circular dichroism [abr] ED"5"0; effective dose fifty [abr] FMRFamide; [abr] HPLC; high performance liquid chromatography [abr] PON; periodically oscillating neuron [abr] SIMS; secondary ionization mass spectrometry [abr] TAN; tonically autoactive neuron [abr] Tris; tris-(hyroxymethyl) aminomethane [abr] VG1; visceral ganglion neuron [abr] ^1H-NMR; proton nuclear magnetic resonance [abr] d-LCDN; dorsal left cerebral distinct neuron [abr] d-RCDN; dorsal right cerebral distinct neuron [abr] v-RCDN; ventral right cerebral distinct neuron [abr] CD; circular dichroism [abr] ED"5"0; effective dose fifty [abr] FMRFamide; [abr] HPLC; high performance liquid chromatography [abr] PON; periodically oscillating neuron [abr] SIMS; secondary ionization mass spectrometry [abr] TAN; tonically autoactive neuron [abr] Tris; tris-(hyroxymethyl) aminomethane [abr] VG1; visceral ganglion neuron [abr] ^1H-NMR; proton nuclear magnetic resonance [abr] d-LCDN; dorsal left cerebral distinct neuron [abr] d-RCDN; dorsal right cerebral distinct neuron [abr] v-RCDN; ventral right cerebral distinct neuron 0006-291X 0006291X Elsevier |
| shingle_title_1 | Achatin-I, an endogenous neuroexcitatory tetrapeptide from achatina fulica ferussac containing A d-amino acid residue |
| shingle_title_2 | Achatin-I, an endogenous neuroexcitatory tetrapeptide from achatina fulica ferussac containing A d-amino acid residue |
| shingle_title_3 | Achatin-I, an endogenous neuroexcitatory tetrapeptide from achatina fulica ferussac containing A d-amino acid residue |
| shingle_title_4 | Achatin-I, an endogenous neuroexcitatory tetrapeptide from achatina fulica ferussac containing A d-amino acid residue |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:45:39.143Z |
| titel | Achatin-I, an endogenous neuroexcitatory tetrapeptide from achatina fulica ferussac containing A d-amino acid residue |
| titel_suche | Achatin-I, an endogenous neuroexcitatory tetrapeptide from achatina fulica ferussac containing A d-amino acid residue A tetrapeptide named achatin-I was purified from the suboesophageal and cerebral ganglia of the African giant snail Achatina fulica Ferussac, and evoked a potent neuroexcitatory effect. The amino acid sequence of achatin-I is Gly-d-Phe-Ala-Asp. Achatin-I induced a voltage-dependent inward current, due to Na^+, on the identifiable giant neuron, periodically oscillating neuron (PON), of the same snail. All possible isomers of achatin-I were synthesized using the solid-phase method. The sensitivity of the neuron to achatin-I and its isomers was strictly stereospecific; among the various isomers, only achatin-I showed marked effects (ED"5"0=2.29x 10^-^6M), while Gly-d-Ala-Asp, the synthetic d-Ala-isomer, was less than 10^-^3 active. |
| topic | W V U |
| uid | nat_lic_papers_NLZ184947456 |