Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver
Ingelman-Sundberg, M. ; Johansson, I. ; Penttila, K.E. ; Glaumann, H. ; Lindros, K.O.
Amsterdam : Elsevier
Amsterdam : Elsevier
| ISSN: |
0006-291X
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|---|---|
| Keywords: |
[abr] ALT; alanine aminotransferase ; [abr] GS; glutamine synthetase ; [abr] P-450IIB1/2; phenobarbital inducible microsomal cytochrome P-450 ; [abr] P-450IIE1; ethanol inducible microsomal cytochrome P-450 (P-450j
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| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
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| Topics: |
Biology
Chemistry and Pharmacology
Physics
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| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798292257360576512 |
|---|---|
| autor | Ingelman-Sundberg, M. Johansson, I. Penttila, K.E. Glaumann, H. Lindros, K.O. |
| autorsonst | Ingelman-Sundberg, M. Johansson, I. Penttila, K.E. Glaumann, H. Lindros, K.O. |
| book_url | http://dx.doi.org/10.1016/S0006-291X(88)80010-X |
| datenlieferant | nat_lic_papers |
| fussnote | Western blot analysis of digitonin eluates as well as immunohistochemical analysis revealed a 30-fold higher concentration of cytochrome P-450IIE1 in the centrilobular than in the periportal regions of the rat liver. Ethanol treatment caused a selective centrilobular induction of P-450IIE1, whereas phenobarbital induced P-450IIB1/2 in both liver lobule regions. The heterogeneous distribution pattern of P-450IIE1 was also observed in cells isolated from either region and correlated to the relative content of P-450IIE1 mRNA in the two cell types. The regiospecific expression and induction of P-450IIE1 may explain why several hepatotoxins, known to be metabolized by this isozyme, primarily damage the centrilobular region in the liver. |
| hauptsatz | hsatz_simple |
| identnr | NLZ184944740 |
| issn | 0006-291X |
| journal_name | Biochemical and Biophysical Research Communications |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 157 (1988), S. 55-60 |
| schlagwort | [abr] ALT; alanine aminotransferase [abr] GS; glutamine synthetase [abr] P-450IIB1/2; phenobarbital inducible microsomal cytochrome P-450 [abr] P-450IIE1; ethanol inducible microsomal cytochrome P-450 (P-450j |
| search_space | articles |
| shingle_author_1 | Ingelman-Sundberg, M. Johansson, I. Penttila, K.E. Glaumann, H. Lindros, K.O. |
| shingle_author_2 | Ingelman-Sundberg, M. Johansson, I. Penttila, K.E. Glaumann, H. Lindros, K.O. |
| shingle_author_3 | Ingelman-Sundberg, M. Johansson, I. Penttila, K.E. Glaumann, H. Lindros, K.O. |
| shingle_author_4 | Ingelman-Sundberg, M. Johansson, I. Penttila, K.E. Glaumann, H. Lindros, K.O. |
| shingle_catch_all_1 | Ingelman-Sundberg, M. Johansson, I. Penttila, K.E. Glaumann, H. Lindros, K.O. Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver [abr] ALT; alanine aminotransferase [abr] GS; glutamine synthetase [abr] P-450IIB1/2; phenobarbital inducible microsomal cytochrome P-450 [abr] P-450IIE1; ethanol inducible microsomal cytochrome P-450 (P-450j [abr] ALT; alanine aminotransferase [abr] GS; glutamine synthetase [abr] P-450IIB1/2; phenobarbital inducible microsomal cytochrome P-450 [abr] P-450IIE1; ethanol inducible microsomal cytochrome P-450 (P-450j 0006-291X 0006291X Elsevier |
| shingle_catch_all_2 | Ingelman-Sundberg, M. Johansson, I. Penttila, K.E. Glaumann, H. Lindros, K.O. Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver [abr] ALT; alanine aminotransferase [abr] GS; glutamine synthetase [abr] P-450IIB1/2; phenobarbital inducible microsomal cytochrome P-450 [abr] P-450IIE1; ethanol inducible microsomal cytochrome P-450 (P-450j [abr] ALT; alanine aminotransferase [abr] GS; glutamine synthetase [abr] P-450IIB1/2; phenobarbital inducible microsomal cytochrome P-450 [abr] P-450IIE1; ethanol inducible microsomal cytochrome P-450 (P-450j 0006-291X 0006291X Elsevier |
| shingle_catch_all_3 | Ingelman-Sundberg, M. Johansson, I. Penttila, K.E. Glaumann, H. Lindros, K.O. Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver [abr] ALT; alanine aminotransferase [abr] GS; glutamine synthetase [abr] P-450IIB1/2; phenobarbital inducible microsomal cytochrome P-450 [abr] P-450IIE1; ethanol inducible microsomal cytochrome P-450 (P-450j [abr] ALT; alanine aminotransferase [abr] GS; glutamine synthetase [abr] P-450IIB1/2; phenobarbital inducible microsomal cytochrome P-450 [abr] P-450IIE1; ethanol inducible microsomal cytochrome P-450 (P-450j 0006-291X 0006291X Elsevier |
| shingle_catch_all_4 | Ingelman-Sundberg, M. Johansson, I. Penttila, K.E. Glaumann, H. Lindros, K.O. Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver [abr] ALT; alanine aminotransferase [abr] GS; glutamine synthetase [abr] P-450IIB1/2; phenobarbital inducible microsomal cytochrome P-450 [abr] P-450IIE1; ethanol inducible microsomal cytochrome P-450 (P-450j [abr] ALT; alanine aminotransferase [abr] GS; glutamine synthetase [abr] P-450IIB1/2; phenobarbital inducible microsomal cytochrome P-450 [abr] P-450IIE1; ethanol inducible microsomal cytochrome P-450 (P-450j 0006-291X 0006291X Elsevier |
| shingle_title_1 | Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver |
| shingle_title_2 | Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver |
| shingle_title_3 | Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver |
| shingle_title_4 | Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:45:39.143Z |
| titel | Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver |
| titel_suche | Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver Western blot analysis of digitonin eluates as well as immunohistochemical analysis revealed a 30-fold higher concentration of cytochrome P-450IIE1 in the centrilobular than in the periportal regions of the rat liver. Ethanol treatment caused a selective centrilobular induction of P-450IIE1, whereas phenobarbital induced P-450IIB1/2 in both liver lobule regions. The heterogeneous distribution pattern of P-450IIE1 was also observed in cells isolated from either region and correlated to the relative content of P-450IIE1 mRNA in the two cell types. The regiospecific expression and induction of P-450IIE1 may explain why several hepatotoxins, known to be metabolized by this isozyme, primarily damage the centrilobular region in the liver. |
| topic | W V U |
| uid | nat_lic_papers_NLZ184944740 |