Effects of gluconeogenic hormones on insulin binding in intact human red blood cells
| ISSN: |
0006-291X
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|---|---|
| Keywords: |
[abr] EDTA; ethylenediaminetetra-acetic acid ; [abr] Hepes,; 4-(2-hydroxyethyl)-1-piperazine-ethanesulphonic acid ; [abr] tris; tris (hydroxymethyl) aminomethane
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| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
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| Topics: |
Biology
Chemistry and Pharmacology
Physics
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798292256732479488 |
|---|---|
| autor | Mokoena, L. Alberts, M. Tyobeka, E. |
| autorsonst | Mokoena, L. Alberts, M. Tyobeka, E. |
| book_url | http://dx.doi.org/10.1016/S0006-291X(87)80101-8 |
| datenlieferant | nat_lic_papers |
| fussnote | The effects of gluconeogenic hormones, adrenaline and cortisol, on insulin binding were studied in intact human red blood cells. Insulin binding was significantly decreased when red blood cells were preincubated with 1.0 ug.ml^-^1 adrenaline or cortisol respectively. The Scatchard plot suggested that this was due to a decrease in surface receptor concentration. Furthermore, it showed that adrenaline also increased insulin receptor affinity. The negative co-operativity affinity profile demonstrated that adrenaline caused a rise in only the upper limit average affinity, K"i, of the insulin receptor. |
| hauptsatz | hsatz_simple |
| identnr | NLZ184902789 |
| issn | 0006-291X |
| journal_name | Biochemical and Biophysical Research Communications |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 147 (1987), S. 158-167 |
| schlagwort | [abr] EDTA; ethylenediaminetetra-acetic acid [abr] Hepes,; 4-(2-hydroxyethyl)-1-piperazine-ethanesulphonic acid [abr] tris; tris (hydroxymethyl) aminomethane |
| search_space | articles |
| shingle_author_1 | Mokoena, L. Alberts, M. Tyobeka, E. |
| shingle_author_2 | Mokoena, L. Alberts, M. Tyobeka, E. |
| shingle_author_3 | Mokoena, L. Alberts, M. Tyobeka, E. |
| shingle_author_4 | Mokoena, L. Alberts, M. Tyobeka, E. |
| shingle_catch_all_1 | Mokoena, L. Alberts, M. Tyobeka, E. Effects of gluconeogenic hormones on insulin binding in intact human red blood cells [abr] EDTA; ethylenediaminetetra-acetic acid [abr] Hepes,; 4-(2-hydroxyethyl)-1-piperazine-ethanesulphonic acid [abr] tris; tris (hydroxymethyl) aminomethane [abr] EDTA; ethylenediaminetetra-acetic acid [abr] Hepes,; 4-(2-hydroxyethyl)-1-piperazine-ethanesulphonic acid [abr] tris; tris (hydroxymethyl) aminomethane 0006-291X 0006291X Elsevier |
| shingle_catch_all_2 | Mokoena, L. Alberts, M. Tyobeka, E. Effects of gluconeogenic hormones on insulin binding in intact human red blood cells [abr] EDTA; ethylenediaminetetra-acetic acid [abr] Hepes,; 4-(2-hydroxyethyl)-1-piperazine-ethanesulphonic acid [abr] tris; tris (hydroxymethyl) aminomethane [abr] EDTA; ethylenediaminetetra-acetic acid [abr] Hepes,; 4-(2-hydroxyethyl)-1-piperazine-ethanesulphonic acid [abr] tris; tris (hydroxymethyl) aminomethane 0006-291X 0006291X Elsevier |
| shingle_catch_all_3 | Mokoena, L. Alberts, M. Tyobeka, E. Effects of gluconeogenic hormones on insulin binding in intact human red blood cells [abr] EDTA; ethylenediaminetetra-acetic acid [abr] Hepes,; 4-(2-hydroxyethyl)-1-piperazine-ethanesulphonic acid [abr] tris; tris (hydroxymethyl) aminomethane [abr] EDTA; ethylenediaminetetra-acetic acid [abr] Hepes,; 4-(2-hydroxyethyl)-1-piperazine-ethanesulphonic acid [abr] tris; tris (hydroxymethyl) aminomethane 0006-291X 0006291X Elsevier |
| shingle_catch_all_4 | Mokoena, L. Alberts, M. Tyobeka, E. Effects of gluconeogenic hormones on insulin binding in intact human red blood cells [abr] EDTA; ethylenediaminetetra-acetic acid [abr] Hepes,; 4-(2-hydroxyethyl)-1-piperazine-ethanesulphonic acid [abr] tris; tris (hydroxymethyl) aminomethane [abr] EDTA; ethylenediaminetetra-acetic acid [abr] Hepes,; 4-(2-hydroxyethyl)-1-piperazine-ethanesulphonic acid [abr] tris; tris (hydroxymethyl) aminomethane 0006-291X 0006291X Elsevier |
| shingle_title_1 | Effects of gluconeogenic hormones on insulin binding in intact human red blood cells |
| shingle_title_2 | Effects of gluconeogenic hormones on insulin binding in intact human red blood cells |
| shingle_title_3 | Effects of gluconeogenic hormones on insulin binding in intact human red blood cells |
| shingle_title_4 | Effects of gluconeogenic hormones on insulin binding in intact human red blood cells |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:45:37.211Z |
| titel | Effects of gluconeogenic hormones on insulin binding in intact human red blood cells |
| titel_suche | Effects of gluconeogenic hormones on insulin binding in intact human red blood cells The effects of gluconeogenic hormones, adrenaline and cortisol, on insulin binding were studied in intact human red blood cells. Insulin binding was significantly decreased when red blood cells were preincubated with 1.0 ug.ml^-^1 adrenaline or cortisol respectively. The Scatchard plot suggested that this was due to a decrease in surface receptor concentration. Furthermore, it showed that adrenaline also increased insulin receptor affinity. The negative co-operativity affinity profile demonstrated that adrenaline caused a rise in only the upper limit average affinity, K"i, of the insulin receptor. |
| topic | W V U |
| uid | nat_lic_papers_NLZ184902789 |