Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel
Traupe, H. ; van den Ouweland, A.M.W. ; van Oost, B.A. ; Vogel, W. ; Vetter, U. ; Warren, S.T. ; Rocchi, M. ; Darlison, M.G. ; Ropers, H.-H.
Amsterdam : Elsevier
Amsterdam : Elsevier
| ISSN: |
0888-7543
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|---|---|
| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
|
| Topics: |
Biology
Medicine
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798292085101559808 |
|---|---|
| autor | Traupe, H. van den Ouweland, A.M.W. van Oost, B.A. Vogel, W. Vetter, U. Warren, S.T. Rocchi, M. Darlison, M.G. Ropers, H.-H. |
| autorsonst | Traupe, H. van den Ouweland, A.M.W. van Oost, B.A. Vogel, W. Vetter, U. Warren, S.T. Rocchi, M. Darlison, M.G. Ropers, H.-H. |
| book_url | http://dx.doi.org/10.1016/0888-7543(92)90279-2 |
| datenlieferant | nat_lic_papers |
| fussnote | Human biglycan is a small proteoglycan that is expressed at high levels in the growing skeleton and in human skin at the cell surface of differentiating keratinocytes. The human gene for biglycan (BGN) has previously been mapped by in situ hybridization to the Xq27-q28 region. Employing somatic hybrid cell lines with human X chromosome breakpoints within this region, we performed a fine mapping of the gene within Xq28. Our results indicate that the biglycan gene is proximal to the red/green cone pigment genes, G6PD, and coagulation factor VIII and is distal to DXS304, DXS305, and GABRA3. The biglycan gene precisely maps to a region of the X chromosome, where, by comparative gene mapping, one would expect to find the gene for X-linked dominant chondrodysplasia punctata/ichthyosis/short stature (Happle) syndrome. Hence, BGN is a candidate gene for the Happle syndrome. |
| hauptsatz | hsatz_simple |
| identnr | NLZ184409691 |
| issn | 0888-7543 |
| journal_name | Genomics |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 13 (1992), S. 481-483 |
| search_space | articles |
| shingle_author_1 | Traupe, H. van den Ouweland, A.M.W. van Oost, B.A. Vogel, W. Vetter, U. Warren, S.T. Rocchi, M. Darlison, M.G. Ropers, H.-H. |
| shingle_author_2 | Traupe, H. van den Ouweland, A.M.W. van Oost, B.A. Vogel, W. Vetter, U. Warren, S.T. Rocchi, M. Darlison, M.G. Ropers, H.-H. |
| shingle_author_3 | Traupe, H. van den Ouweland, A.M.W. van Oost, B.A. Vogel, W. Vetter, U. Warren, S.T. Rocchi, M. Darlison, M.G. Ropers, H.-H. |
| shingle_author_4 | Traupe, H. van den Ouweland, A.M.W. van Oost, B.A. Vogel, W. Vetter, U. Warren, S.T. Rocchi, M. Darlison, M.G. Ropers, H.-H. |
| shingle_catch_all_1 | Traupe, H. van den Ouweland, A.M.W. van Oost, B.A. Vogel, W. Vetter, U. Warren, S.T. Rocchi, M. Darlison, M.G. Ropers, H.-H. Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel 0888-7543 08887543 Elsevier |
| shingle_catch_all_2 | Traupe, H. van den Ouweland, A.M.W. van Oost, B.A. Vogel, W. Vetter, U. Warren, S.T. Rocchi, M. Darlison, M.G. Ropers, H.-H. Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel 0888-7543 08887543 Elsevier |
| shingle_catch_all_3 | Traupe, H. van den Ouweland, A.M.W. van Oost, B.A. Vogel, W. Vetter, U. Warren, S.T. Rocchi, M. Darlison, M.G. Ropers, H.-H. Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel 0888-7543 08887543 Elsevier |
| shingle_catch_all_4 | Traupe, H. van den Ouweland, A.M.W. van Oost, B.A. Vogel, W. Vetter, U. Warren, S.T. Rocchi, M. Darlison, M.G. Ropers, H.-H. Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel 0888-7543 08887543 Elsevier |
| shingle_title_1 | Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel |
| shingle_title_2 | Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel |
| shingle_title_3 | Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel |
| shingle_title_4 | Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:42:54.371Z |
| titel | Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel |
| titel_suche | Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel Human biglycan is a small proteoglycan that is expressed at high levels in the growing skeleton and in human skin at the cell surface of differentiating keratinocytes. The human gene for biglycan (BGN) has previously been mapped by in situ hybridization to the Xq27-q28 region. Employing somatic hybrid cell lines with human X chromosome breakpoints within this region, we performed a fine mapping of the gene within Xq28. Our results indicate that the biglycan gene is proximal to the red/green cone pigment genes, G6PD, and coagulation factor VIII and is distal to DXS304, DXS305, and GABRA3. The biglycan gene precisely maps to a region of the X chromosome, where, by comparative gene mapping, one would expect to find the gene for X-linked dominant chondrodysplasia punctata/ichthyosis/short stature (Happle) syndrome. Hence, BGN is a candidate gene for the Happle syndrome. |
| topic | W WW-YZ |
| uid | nat_lic_papers_NLZ184409691 |