High conservation of sequences involved in cystic fibrosis mutations in five mammalian species
| ISSN: |
0888-7543
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|---|---|
| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
|
| Topics: |
Biology
Medicine
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798292085925740544 |
|---|---|
| autor | Gasparini, P. Nunes, V. Dognini, M. Estivill, X. |
| autorsonst | Gasparini, P. Nunes, V. Dognini, M. Estivill, X. |
| book_url | http://dx.doi.org/10.1016/0888-7543(91)90200-X |
| datenlieferant | nat_lic_papers |
| fussnote | Several mutations have been identified in the first nucleocide binding fold (NBF) of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene. We have analyzed the DNA sequences of exons 10 and 11 in five different mammalian species, marmoset, mouse, cow, pig, and sheep; the amino acid conservation studied for nine disease mutations; and two ''benign'' mutations. For exon 10,87% homology at the DNA level and 93.5% at the amino acid level were found for these species. For exon 11, the lowest homology (70%), as found in mouse and the highest in marmoset (93%), whereas the amino acid sequence conservation ranged from 82.5 to 100%. All codons involved in CF mutations are highly conserved throughout evolution. |
| hauptsatz | hsatz_simple |
| identnr | NLZ18440424X |
| issn | 0888-7543 |
| journal_name | Genomics |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 10 (1991), S. 1070-1072 |
| search_space | articles |
| shingle_author_1 | Gasparini, P. Nunes, V. Dognini, M. Estivill, X. |
| shingle_author_2 | Gasparini, P. Nunes, V. Dognini, M. Estivill, X. |
| shingle_author_3 | Gasparini, P. Nunes, V. Dognini, M. Estivill, X. |
| shingle_author_4 | Gasparini, P. Nunes, V. Dognini, M. Estivill, X. |
| shingle_catch_all_1 | Gasparini, P. Nunes, V. Dognini, M. Estivill, X. High conservation of sequences involved in cystic fibrosis mutations in five mammalian species 0888-7543 08887543 Elsevier |
| shingle_catch_all_2 | Gasparini, P. Nunes, V. Dognini, M. Estivill, X. High conservation of sequences involved in cystic fibrosis mutations in five mammalian species 0888-7543 08887543 Elsevier |
| shingle_catch_all_3 | Gasparini, P. Nunes, V. Dognini, M. Estivill, X. High conservation of sequences involved in cystic fibrosis mutations in five mammalian species 0888-7543 08887543 Elsevier |
| shingle_catch_all_4 | Gasparini, P. Nunes, V. Dognini, M. Estivill, X. High conservation of sequences involved in cystic fibrosis mutations in five mammalian species 0888-7543 08887543 Elsevier |
| shingle_title_1 | High conservation of sequences involved in cystic fibrosis mutations in five mammalian species |
| shingle_title_2 | High conservation of sequences involved in cystic fibrosis mutations in five mammalian species |
| shingle_title_3 | High conservation of sequences involved in cystic fibrosis mutations in five mammalian species |
| shingle_title_4 | High conservation of sequences involved in cystic fibrosis mutations in five mammalian species |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:42:54.116Z |
| titel | High conservation of sequences involved in cystic fibrosis mutations in five mammalian species |
| titel_suche | High conservation of sequences involved in cystic fibrosis mutations in five mammalian species Several mutations have been identified in the first nucleocide binding fold (NBF) of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene. We have analyzed the DNA sequences of exons 10 and 11 in five different mammalian species, marmoset, mouse, cow, pig, and sheep; the amino acid conservation studied for nine disease mutations; and two ''benign'' mutations. For exon 10,87% homology at the DNA level and 93.5% at the amino acid level were found for these species. For exon 11, the lowest homology (70%), as found in mouse and the highest in marmoset (93%), whereas the amino acid sequence conservation ranged from 82.5 to 100%. All codons involved in CF mutations are highly conserved throughout evolution. |
| topic | W WW-YZ |
| uid | nat_lic_papers_NLZ18440424X |