Short-term control of the pentose phosphate cycle by insulin could be modulated by the NADPHNADP ratio in rat adipocytes and hepatocytes
| ISSN: |
0006-291X
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|---|---|
| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
|
| Topics: |
Biology
Chemistry and Pharmacology
Physics
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798292248254742529 |
|---|---|
| autor | Fabregat, I. Revilla, E. Machado, A. |
| autorsonst | Fabregat, I. Revilla, E. Machado, A. |
| book_url | http://dx.doi.org/10.1016/0006-291X(87)90618-8 |
| datenlieferant | nat_lic_papers |
| fussnote | The short-term activation of the pentose phosphate cycle by insulin in rat adipocytes and hepatocytes has been studied. This NADPH-producing pathway is regulated by the activation or inhibition of different NADPH-consuming pathways. The stimulation of the fatty acid synthesis by insulin produced an increase in the flux through the pentose phosphate cycle. Kynurenate produced a decrease in the fatty acid synthesis and, consequently a diminution in the flux through the pentose phosphate cycle. Incubation of adipocytes and hepatocytes in presence of kynurenate (10 mM and 3 mM respectively) and insulin (5 nM), prevents both insulin activation on fatty acid synthesis and pentose phosphate cycle. These results suggest that insulin actives the pentose phosphate cycle through the activation of fatty acid synthesis. |
| hauptsatz | hsatz_simple |
| identnr | NLZ184184592 |
| issn | 0006-291X |
| journal_name | Biochemical and Biophysical Research Communications |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 146 (1987), S. 920-925 |
| search_space | articles |
| shingle_author_1 | Fabregat, I. Revilla, E. Machado, A. |
| shingle_author_2 | Fabregat, I. Revilla, E. Machado, A. |
| shingle_author_3 | Fabregat, I. Revilla, E. Machado, A. |
| shingle_author_4 | Fabregat, I. Revilla, E. Machado, A. |
| shingle_catch_all_1 | Fabregat, I. Revilla, E. Machado, A. Short-term control of the pentose phosphate cycle by insulin could be modulated by the NADPHNADP ratio in rat adipocytes and hepatocytes 0006-291X 0006291X Elsevier |
| shingle_catch_all_2 | Fabregat, I. Revilla, E. Machado, A. Short-term control of the pentose phosphate cycle by insulin could be modulated by the NADPHNADP ratio in rat adipocytes and hepatocytes 0006-291X 0006291X Elsevier |
| shingle_catch_all_3 | Fabregat, I. Revilla, E. Machado, A. Short-term control of the pentose phosphate cycle by insulin could be modulated by the NADPHNADP ratio in rat adipocytes and hepatocytes 0006-291X 0006291X Elsevier |
| shingle_catch_all_4 | Fabregat, I. Revilla, E. Machado, A. Short-term control of the pentose phosphate cycle by insulin could be modulated by the NADPHNADP ratio in rat adipocytes and hepatocytes 0006-291X 0006291X Elsevier |
| shingle_title_1 | Short-term control of the pentose phosphate cycle by insulin could be modulated by the NADPHNADP ratio in rat adipocytes and hepatocytes |
| shingle_title_2 | Short-term control of the pentose phosphate cycle by insulin could be modulated by the NADPHNADP ratio in rat adipocytes and hepatocytes |
| shingle_title_3 | Short-term control of the pentose phosphate cycle by insulin could be modulated by the NADPHNADP ratio in rat adipocytes and hepatocytes |
| shingle_title_4 | Short-term control of the pentose phosphate cycle by insulin could be modulated by the NADPHNADP ratio in rat adipocytes and hepatocytes |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:45:30.315Z |
| titel | Short-term control of the pentose phosphate cycle by insulin could be modulated by the NADPHNADP ratio in rat adipocytes and hepatocytes |
| titel_suche | Short-term control of the pentose phosphate cycle by insulin could be modulated by the NADPHNADP ratio in rat adipocytes and hepatocytes The short-term activation of the pentose phosphate cycle by insulin in rat adipocytes and hepatocytes has been studied. This NADPH-producing pathway is regulated by the activation or inhibition of different NADPH-consuming pathways. The stimulation of the fatty acid synthesis by insulin produced an increase in the flux through the pentose phosphate cycle. Kynurenate produced a decrease in the fatty acid synthesis and, consequently a diminution in the flux through the pentose phosphate cycle. Incubation of adipocytes and hepatocytes in presence of kynurenate (10 mM and 3 mM respectively) and insulin (5 nM), prevents both insulin activation on fatty acid synthesis and pentose phosphate cycle. These results suggest that insulin actives the pentose phosphate cycle through the activation of fatty acid synthesis. |
| topic | W V U |
| uid | nat_lic_papers_NLZ184184592 |