Specific Interaction between a Novel Enediyne Chromophore and Apoprotein in Macromolecular Antitumor Antibiotic C-1027
| ISSN: |
0006-291X
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|---|---|
| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
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| Topics: |
Biology
Chemistry and Pharmacology
Physics
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798292264927100928 |
|---|---|
| autor | Matsumoto, T. Okuno, Y. Sugiura, Y. |
| autorsonst | Matsumoto, T. Okuno, Y. Sugiura, Y. |
| book_url | http://dx.doi.org/10.1006/bbrc.1993.2096 |
| datenlieferant | nat_lic_papers |
| fussnote | The DNA cleavage experiments show that C-1027 chromophore is selectively incorporated into C-1027 apoprotein and is strongly protected by the apoprotein from loss of its DNA cleaving activity. Fluorescence and circular dichroism spectra reveal (1) important participation of tertiary structure of C-1027 apoprotein for the chromophore binding, (2) specific 1:1 binding of C-1027 chromophore to the apoprotein, and (3) significant interaction of the benzoxazine group in the chromophore-apoprotein complex. On the other hand, C-1027 apoprotein does not contribute to sequence-specificity DNA cleavage by C-1027 antibiotics. |
| hauptsatz | hsatz_simple |
| identnr | NLZ183483960 |
| issn | 0006-291X |
| journal_name | Biochemical and Biophysical Research Communications |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 195 (1993), S. 659-666 |
| search_space | articles |
| shingle_author_1 | Matsumoto, T. Okuno, Y. Sugiura, Y. |
| shingle_author_2 | Matsumoto, T. Okuno, Y. Sugiura, Y. |
| shingle_author_3 | Matsumoto, T. Okuno, Y. Sugiura, Y. |
| shingle_author_4 | Matsumoto, T. Okuno, Y. Sugiura, Y. |
| shingle_catch_all_1 | Matsumoto, T. Okuno, Y. Sugiura, Y. Specific Interaction between a Novel Enediyne Chromophore and Apoprotein in Macromolecular Antitumor Antibiotic C-1027 0006-291X 0006291X Elsevier |
| shingle_catch_all_2 | Matsumoto, T. Okuno, Y. Sugiura, Y. Specific Interaction between a Novel Enediyne Chromophore and Apoprotein in Macromolecular Antitumor Antibiotic C-1027 0006-291X 0006291X Elsevier |
| shingle_catch_all_3 | Matsumoto, T. Okuno, Y. Sugiura, Y. Specific Interaction between a Novel Enediyne Chromophore and Apoprotein in Macromolecular Antitumor Antibiotic C-1027 0006-291X 0006291X Elsevier |
| shingle_catch_all_4 | Matsumoto, T. Okuno, Y. Sugiura, Y. Specific Interaction between a Novel Enediyne Chromophore and Apoprotein in Macromolecular Antitumor Antibiotic C-1027 0006-291X 0006291X Elsevier |
| shingle_title_1 | Specific Interaction between a Novel Enediyne Chromophore and Apoprotein in Macromolecular Antitumor Antibiotic C-1027 |
| shingle_title_2 | Specific Interaction between a Novel Enediyne Chromophore and Apoprotein in Macromolecular Antitumor Antibiotic C-1027 |
| shingle_title_3 | Specific Interaction between a Novel Enediyne Chromophore and Apoprotein in Macromolecular Antitumor Antibiotic C-1027 |
| shingle_title_4 | Specific Interaction between a Novel Enediyne Chromophore and Apoprotein in Macromolecular Antitumor Antibiotic C-1027 |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:45:46.431Z |
| titel | Specific Interaction between a Novel Enediyne Chromophore and Apoprotein in Macromolecular Antitumor Antibiotic C-1027 |
| titel_suche | Specific Interaction between a Novel Enediyne Chromophore and Apoprotein in Macromolecular Antitumor Antibiotic C-1027 The DNA cleavage experiments show that C-1027 chromophore is selectively incorporated into C-1027 apoprotein and is strongly protected by the apoprotein from loss of its DNA cleaving activity. Fluorescence and circular dichroism spectra reveal (1) important participation of tertiary structure of C-1027 apoprotein for the chromophore binding, (2) specific 1:1 binding of C-1027 chromophore to the apoprotein, and (3) significant interaction of the benzoxazine group in the chromophore-apoprotein complex. On the other hand, C-1027 apoprotein does not contribute to sequence-specificity DNA cleavage by C-1027 antibiotics. |
| topic | W V U |
| uid | nat_lic_papers_NLZ183483960 |