Cellular Mechanism of Glyburide-Induced Insulin Gene Expression in Isolated Rat Islets
Yamato, E. ; Ikegami, H. ; Tahara, Y. ; Fukuda, M. ; Cha, T. ; Kawaguchi, Y. ; Fujioka, Y. ; Noma, Y. ; Shima, K. ; Ogihara, T.
Amsterdam : Elsevier
Amsterdam : Elsevier
| ISSN: |
0006-291X
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|---|---|
| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
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| Topics: |
Biology
Chemistry and Pharmacology
Physics
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| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798292264630353921 |
|---|---|
| autor | Yamato, E. Ikegami, H. Tahara, Y. Fukuda, M. Cha, T. Kawaguchi, Y. Fujioka, Y. Noma, Y. Shima, K. Ogihara, T. |
| autorsonst | Yamato, E. Ikegami, H. Tahara, Y. Fukuda, M. Cha, T. Kawaguchi, Y. Fujioka, Y. Noma, Y. Shima, K. Ogihara, T. |
| book_url | http://dx.doi.org/10.1006/bbrc.1993.2572 |
| datenlieferant | nat_lic_papers |
| fussnote | The cellular mechanism for the effects of glyburide on the synthesis and release of insulin and insulin gene expression in isolated islets was investigated. On incubation for 1 h, glyburide increased insulin release without affecting either the insulin content or the PPI mRNA level. H-7, an inhibitor of PKC, inhibited the glyburide-induced insulin release, while H-8, an inhibitor of cyclic nucleotide-dependent protein kinases, did not affect the glyburide-induced insulin release. On incubation for 20 h, glyburide increased insulin release and the PPI mRNA level, without affecting the insulin content. H-7 inhibited glyburide-induced insulin release and increased the PPI mRNA level. H-8 significantly inhibited both the glyburide-induced increase in insulin release and increase in PPI mRNA level. In conclusion, glyburide stimulated insulin release via a PKC-mediated pathway and increased the PPI mRNA level via cyclic nucleotide-dependent protein kinase(s). |
| hauptsatz | hsatz_simple |
| identnr | NLZ183482875 |
| issn | 0006-291X |
| journal_name | Biochemical and Biophysical Research Communications |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 197 (1993), S. 957-964 |
| search_space | articles |
| shingle_author_1 | Yamato, E. Ikegami, H. Tahara, Y. Fukuda, M. Cha, T. Kawaguchi, Y. Fujioka, Y. Noma, Y. Shima, K. Ogihara, T. |
| shingle_author_2 | Yamato, E. Ikegami, H. Tahara, Y. Fukuda, M. Cha, T. Kawaguchi, Y. Fujioka, Y. Noma, Y. Shima, K. Ogihara, T. |
| shingle_author_3 | Yamato, E. Ikegami, H. Tahara, Y. Fukuda, M. Cha, T. Kawaguchi, Y. Fujioka, Y. Noma, Y. Shima, K. Ogihara, T. |
| shingle_author_4 | Yamato, E. Ikegami, H. Tahara, Y. Fukuda, M. Cha, T. Kawaguchi, Y. Fujioka, Y. Noma, Y. Shima, K. Ogihara, T. |
| shingle_catch_all_1 | Yamato, E. Ikegami, H. Tahara, Y. Fukuda, M. Cha, T. Kawaguchi, Y. Fujioka, Y. Noma, Y. Shima, K. Ogihara, T. Cellular Mechanism of Glyburide-Induced Insulin Gene Expression in Isolated Rat Islets 0006-291X 0006291X Elsevier |
| shingle_catch_all_2 | Yamato, E. Ikegami, H. Tahara, Y. Fukuda, M. Cha, T. Kawaguchi, Y. Fujioka, Y. Noma, Y. Shima, K. Ogihara, T. Cellular Mechanism of Glyburide-Induced Insulin Gene Expression in Isolated Rat Islets 0006-291X 0006291X Elsevier |
| shingle_catch_all_3 | Yamato, E. Ikegami, H. Tahara, Y. Fukuda, M. Cha, T. Kawaguchi, Y. Fujioka, Y. Noma, Y. Shima, K. Ogihara, T. Cellular Mechanism of Glyburide-Induced Insulin Gene Expression in Isolated Rat Islets 0006-291X 0006291X Elsevier |
| shingle_catch_all_4 | Yamato, E. Ikegami, H. Tahara, Y. Fukuda, M. Cha, T. Kawaguchi, Y. Fujioka, Y. Noma, Y. Shima, K. Ogihara, T. Cellular Mechanism of Glyburide-Induced Insulin Gene Expression in Isolated Rat Islets 0006-291X 0006291X Elsevier |
| shingle_title_1 | Cellular Mechanism of Glyburide-Induced Insulin Gene Expression in Isolated Rat Islets |
| shingle_title_2 | Cellular Mechanism of Glyburide-Induced Insulin Gene Expression in Isolated Rat Islets |
| shingle_title_3 | Cellular Mechanism of Glyburide-Induced Insulin Gene Expression in Isolated Rat Islets |
| shingle_title_4 | Cellular Mechanism of Glyburide-Induced Insulin Gene Expression in Isolated Rat Islets |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:45:45.579Z |
| titel | Cellular Mechanism of Glyburide-Induced Insulin Gene Expression in Isolated Rat Islets |
| titel_suche | Cellular Mechanism of Glyburide-Induced Insulin Gene Expression in Isolated Rat Islets The cellular mechanism for the effects of glyburide on the synthesis and release of insulin and insulin gene expression in isolated islets was investigated. On incubation for 1 h, glyburide increased insulin release without affecting either the insulin content or the PPI mRNA level. H-7, an inhibitor of PKC, inhibited the glyburide-induced insulin release, while H-8, an inhibitor of cyclic nucleotide-dependent protein kinases, did not affect the glyburide-induced insulin release. On incubation for 20 h, glyburide increased insulin release and the PPI mRNA level, without affecting the insulin content. H-7 inhibited glyburide-induced insulin release and increased the PPI mRNA level. H-8 significantly inhibited both the glyburide-induced increase in insulin release and increase in PPI mRNA level. In conclusion, glyburide stimulated insulin release via a PKC-mediated pathway and increased the PPI mRNA level via cyclic nucleotide-dependent protein kinase(s). |
| topic | W V U |
| uid | nat_lic_papers_NLZ183482875 |