Molecular Scanning of the Glycogen Synthase and Insulin Receptor Substrate-1 Genes in Japanese Subjects with Non-Insulin-Dependent Diabetes Mellitus

ISSN:
0006-291X
Source:
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
Topics:
Biology
Chemistry and Pharmacology
Physics
Type of Medium:
Electronic Resource
URL:
_version_ 1798292264448950274
autor Shimokawa, K.
Kadowaki, H.
Sakura, H.
Otabe, S.
Hagura, R.
Kosaka, K.
Yazaki, Y.
Akanuma, Y.
Kadowaki, T.
autorsonst Shimokawa, K.
Kadowaki, H.
Sakura, H.
Otabe, S.
Hagura, R.
Kosaka, K.
Yazaki, Y.
Akanuma, Y.
Kadowaki, T.
book_url http://dx.doi.org/10.1006/bbrc.1994.1951
datenlieferant nat_lic_papers
fussnote We studied a simple tandem repeal DNA polymorphism in the glycogen synthase gene and polymorphisms at codon 513 (Ala-〉Pro) and 972 (Gly-〉Arg) in the insulin receptor substrate-1 (IRS-1) gene in 197 non-insulin-dependent diabetes mellitus (NIDDM) and 178 control subjects in Japan. Eight alleles (-3G, -2G, -1G, 0G, 1G, 2G, 3G, and 4G) were identified in the tandem repeat polymorphism in the glycogen synthase gene. No difference in the frequencies of these alleles was found between diabetics and controls. The codon 972 polymorphism of IRS-1 gene was observed in 7 diabetics (3.6%) and 8 controls (4.5%), whereas the codon 513 polymorphism was not found in either of the two groups. We conclude that the tandem repeat polymorphism in the glycogen synthase gene and the polymorphisms at codons 513 and 972 of the IRS-1 gene are not associated with a higher risk for the development of NIDDM in Japanese subjects.
hauptsatz hsatz_simple
identnr NLZ183478126
issn 0006-291X
journal_name Biochemical and Biophysical Research Communications
materialart 1
package_name Elsevier
publikationsort Amsterdam
publisher Elsevier
reference 202 (1994), S. 463-469
search_space articles
shingle_author_1 Shimokawa, K.
Kadowaki, H.
Sakura, H.
Otabe, S.
Hagura, R.
Kosaka, K.
Yazaki, Y.
Akanuma, Y.
Kadowaki, T.
shingle_author_2 Shimokawa, K.
Kadowaki, H.
Sakura, H.
Otabe, S.
Hagura, R.
Kosaka, K.
Yazaki, Y.
Akanuma, Y.
Kadowaki, T.
shingle_author_3 Shimokawa, K.
Kadowaki, H.
Sakura, H.
Otabe, S.
Hagura, R.
Kosaka, K.
Yazaki, Y.
Akanuma, Y.
Kadowaki, T.
shingle_author_4 Shimokawa, K.
Kadowaki, H.
Sakura, H.
Otabe, S.
Hagura, R.
Kosaka, K.
Yazaki, Y.
Akanuma, Y.
Kadowaki, T.
shingle_catch_all_1 Shimokawa, K.
Kadowaki, H.
Sakura, H.
Otabe, S.
Hagura, R.
Kosaka, K.
Yazaki, Y.
Akanuma, Y.
Kadowaki, T.
Molecular Scanning of the Glycogen Synthase and Insulin Receptor Substrate-1 Genes in Japanese Subjects with Non-Insulin-Dependent Diabetes Mellitus
0006-291X
0006291X
Elsevier
shingle_catch_all_2 Shimokawa, K.
Kadowaki, H.
Sakura, H.
Otabe, S.
Hagura, R.
Kosaka, K.
Yazaki, Y.
Akanuma, Y.
Kadowaki, T.
Molecular Scanning of the Glycogen Synthase and Insulin Receptor Substrate-1 Genes in Japanese Subjects with Non-Insulin-Dependent Diabetes Mellitus
0006-291X
0006291X
Elsevier
shingle_catch_all_3 Shimokawa, K.
Kadowaki, H.
Sakura, H.
Otabe, S.
Hagura, R.
Kosaka, K.
Yazaki, Y.
Akanuma, Y.
Kadowaki, T.
Molecular Scanning of the Glycogen Synthase and Insulin Receptor Substrate-1 Genes in Japanese Subjects with Non-Insulin-Dependent Diabetes Mellitus
0006-291X
0006291X
Elsevier
shingle_catch_all_4 Shimokawa, K.
Kadowaki, H.
Sakura, H.
Otabe, S.
Hagura, R.
Kosaka, K.
Yazaki, Y.
Akanuma, Y.
Kadowaki, T.
Molecular Scanning of the Glycogen Synthase and Insulin Receptor Substrate-1 Genes in Japanese Subjects with Non-Insulin-Dependent Diabetes Mellitus
0006-291X
0006291X
Elsevier
shingle_title_1 Molecular Scanning of the Glycogen Synthase and Insulin Receptor Substrate-1 Genes in Japanese Subjects with Non-Insulin-Dependent Diabetes Mellitus
shingle_title_2 Molecular Scanning of the Glycogen Synthase and Insulin Receptor Substrate-1 Genes in Japanese Subjects with Non-Insulin-Dependent Diabetes Mellitus
shingle_title_3 Molecular Scanning of the Glycogen Synthase and Insulin Receptor Substrate-1 Genes in Japanese Subjects with Non-Insulin-Dependent Diabetes Mellitus
shingle_title_4 Molecular Scanning of the Glycogen Synthase and Insulin Receptor Substrate-1 Genes in Japanese Subjects with Non-Insulin-Dependent Diabetes Mellitus
sigel_instance_filter dkfz
geomar
wilbert
ipn
albert
fhp
source_archive Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
timestamp 2024-05-06T08:45:45.422Z
titel Molecular Scanning of the Glycogen Synthase and Insulin Receptor Substrate-1 Genes in Japanese Subjects with Non-Insulin-Dependent Diabetes Mellitus
titel_suche Molecular Scanning of the Glycogen Synthase and Insulin Receptor Substrate-1 Genes in Japanese Subjects with Non-Insulin-Dependent Diabetes Mellitus
We studied a simple tandem repeal DNA polymorphism in the glycogen synthase gene and polymorphisms at codon 513 (Ala-〉Pro) and 972 (Gly-〉Arg) in the insulin receptor substrate-1 (IRS-1) gene in 197 non-insulin-dependent diabetes mellitus (NIDDM) and 178 control subjects in Japan. Eight alleles (-3G, -2G, -1G, 0G, 1G, 2G, 3G, and 4G) were identified in the tandem repeat polymorphism in the glycogen synthase gene. No difference in the frequencies of these alleles was found between diabetics and controls. The codon 972 polymorphism of IRS-1 gene was observed in 7 diabetics (3.6%) and 8 controls (4.5%), whereas the codon 513 polymorphism was not found in either of the two groups. We conclude that the tandem repeat polymorphism in the glycogen synthase gene and the polymorphisms at codons 513 and 972 of the IRS-1 gene are not associated with a higher risk for the development of NIDDM in Japanese subjects.
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