The effect of substituted phenols on liver weights and liver enzymes in the rat: Structure-activity relationships
| ISSN: |
0015-6264
|
|---|---|
| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
|
| Topics: |
Medicine
Process Engineering, Biotechnology, Nutrition Technology
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798292463252668416 |
|---|---|
| autor | Gilbert, D. Martin, A.D. Gangolli, S.D. Abraham, R. Golberg, L. |
| autorsonst | Gilbert, D. Martin, A.D. Gangolli, S.D. Abraham, R. Golberg, L. |
| book_url | http://dx.doi.org/10.1016/S0015-6264(69)80463-3 |
| datenlieferant | nat_lic_papers |
| fussnote | The relative abilities of substituted phenols to induce drug-metabolizing enzymes were measured either 24 hr after a single dose or after 6-10 daily doses. The phenols carried various combinations of the substituents, methyl, ethyl, isopropyl, tert-butyl, tert-amyl, phenyl, benzyl, methoxy, methoxymethyl, hydroxymethyl, dimethylaminomethyl and nitro. When the effect was measured 24 hr after a single dose, a close relationship was found between the induction of drug-metabolizing enzymes and the lipid-water partition coefficient of the test compound. When the effect was measured after six daily doses this relationship was less distinct; further dosing could lead either to an accentuation or to a diminution of the effect. One compound which provided less evidence of induction after six doses than after a single dose was 2,6-di-tert-butyl-4-methoxymethylphenol. This regression of enzyme activity on repeated dosing was not related to any histological change or to the amount or distribution of histochemically-demonstrable glucose 6-phosphatase in the liver. Many of the substituted phenols also induced uridine diphosphate glucose dehydrogenase, an effect apparently unrelated either to the lipid-water partition coefficient or to the induction of drug-metabolizing enzymes. Liver enlargement was not invariably related to the induction of either drug-metabolizingactivities or uridine diphosphate glucose dehydrogenase. |
| hauptsatz | hsatz_simple |
| identnr | NLZ177139889 |
| issn | 0015-6264 |
| journal_name | Food and Cosmetics Toxicology |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 7 (1969), S. 603-619 |
| search_space | articles |
| shingle_author_1 | Gilbert, D. Martin, A.D. Gangolli, S.D. Abraham, R. Golberg, L. |
| shingle_author_2 | Gilbert, D. Martin, A.D. Gangolli, S.D. Abraham, R. Golberg, L. |
| shingle_author_3 | Gilbert, D. Martin, A.D. Gangolli, S.D. Abraham, R. Golberg, L. |
| shingle_author_4 | Gilbert, D. Martin, A.D. Gangolli, S.D. Abraham, R. Golberg, L. |
| shingle_catch_all_1 | Gilbert, D. Martin, A.D. Gangolli, S.D. Abraham, R. Golberg, L. The effect of substituted phenols on liver weights and liver enzymes in the rat: Structure-activity relationships 0015-6264 00156264 Elsevier |
| shingle_catch_all_2 | Gilbert, D. Martin, A.D. Gangolli, S.D. Abraham, R. Golberg, L. The effect of substituted phenols on liver weights and liver enzymes in the rat: Structure-activity relationships 0015-6264 00156264 Elsevier |
| shingle_catch_all_3 | Gilbert, D. Martin, A.D. Gangolli, S.D. Abraham, R. Golberg, L. The effect of substituted phenols on liver weights and liver enzymes in the rat: Structure-activity relationships 0015-6264 00156264 Elsevier |
| shingle_catch_all_4 | Gilbert, D. Martin, A.D. Gangolli, S.D. Abraham, R. Golberg, L. The effect of substituted phenols on liver weights and liver enzymes in the rat: Structure-activity relationships 0015-6264 00156264 Elsevier |
| shingle_title_1 | The effect of substituted phenols on liver weights and liver enzymes in the rat: Structure-activity relationships |
| shingle_title_2 | The effect of substituted phenols on liver weights and liver enzymes in the rat: Structure-activity relationships |
| shingle_title_3 | The effect of substituted phenols on liver weights and liver enzymes in the rat: Structure-activity relationships |
| shingle_title_4 | The effect of substituted phenols on liver weights and liver enzymes in the rat: Structure-activity relationships |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:48:55.120Z |
| titel | The effect of substituted phenols on liver weights and liver enzymes in the rat: Structure-activity relationships |
| titel_suche | The effect of substituted phenols on liver weights and liver enzymes in the rat: Structure-activity relationships The relative abilities of substituted phenols to induce drug-metabolizing enzymes were measured either 24 hr after a single dose or after 6-10 daily doses. The phenols carried various combinations of the substituents, methyl, ethyl, isopropyl, tert-butyl, tert-amyl, phenyl, benzyl, methoxy, methoxymethyl, hydroxymethyl, dimethylaminomethyl and nitro. When the effect was measured 24 hr after a single dose, a close relationship was found between the induction of drug-metabolizing enzymes and the lipid-water partition coefficient of the test compound. When the effect was measured after six daily doses this relationship was less distinct; further dosing could lead either to an accentuation or to a diminution of the effect. One compound which provided less evidence of induction after six doses than after a single dose was 2,6-di-tert-butyl-4-methoxymethylphenol. This regression of enzyme activity on repeated dosing was not related to any histological change or to the amount or distribution of histochemically-demonstrable glucose 6-phosphatase in the liver. Many of the substituted phenols also induced uridine diphosphate glucose dehydrogenase, an effect apparently unrelated either to the lipid-water partition coefficient or to the induction of drug-metabolizing enzymes. Liver enlargement was not invariably related to the induction of either drug-metabolizingactivities or uridine diphosphate glucose dehydrogenase. |
| topic | WW-YZ ZM |
| uid | nat_lic_papers_NLZ177139889 |