Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in alzheimer's brains
Lin, F.H. ; Lin, R. ; Wisniewski, H.M. ; Hwang, Y.W. ; Grundke-Iqbal, I. ; Healy-Louie, G. ; Iqbal, K.
Amsterdam : Elsevier
Amsterdam : Elsevier
| ISSN: |
0006-291X
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|---|---|
| Keywords: |
[abr] ALS; amyotrophic lateral sclerosis ; [abr] ND2; NADH dehydrogenase (EC 1.6.99.3) subunit 2 ; [abr] ND4; NADH dehydrogenase (EC 1.6.99.3) subunit 4 ; [abr] NFT; neurofibrillary tangles ; [abr] PCR; polymerase chain reaction ; [abr] PHF; paired helical filaments ; [abr] SNuPE; single nucleotide primer extension ; [abr] pfu; plaques forming unit
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| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
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| Topics: |
Biology
Chemistry and Pharmacology
Physics
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798292232975941633 |
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| autor | Lin, F.H. Lin, R. Wisniewski, H.M. Hwang, Y.W. Grundke-Iqbal, I. Healy-Louie, G. Iqbal, K. |
| autorsonst | Lin, F.H. Lin, R. Wisniewski, H.M. Hwang, Y.W. Grundke-Iqbal, I. Healy-Louie, G. Iqbal, K. |
| book_url | http://dx.doi.org/10.1016/S0006-291X(05)80136-6 |
| datenlieferant | nat_lic_papers |
| fussnote | Point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 (ND2) were detected in 10 of 19 Alzheimer's brains but not in 11 normal brains. The same mutations were also detected in 2 of 6 patients with amyotrophic lateral sclerosis (ALS). However, neurofibrillary tangles and neuritic plaques characteristic of Alzheimer's disease were found histologically in the brain of one ALS patient who was positive of the mutation. The finding suggests that a point mutation in ND2 is a potential risk factor for Alzheimer's disease. |
| hauptsatz | hsatz_simple |
| identnr | NLZ177001844 |
| issn | 0006-291X |
| journal_name | Biochemical and Biophysical Research Communications |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 182 (1992), S. 238-246 |
| schlagwort | [abr] ALS; amyotrophic lateral sclerosis [abr] ND2; NADH dehydrogenase (EC 1.6.99.3) subunit 2 [abr] ND4; NADH dehydrogenase (EC 1.6.99.3) subunit 4 [abr] NFT; neurofibrillary tangles [abr] PCR; polymerase chain reaction [abr] PHF; paired helical filaments [abr] SNuPE; single nucleotide primer extension [abr] pfu; plaques forming unit |
| search_space | articles |
| shingle_author_1 | Lin, F.H. Lin, R. Wisniewski, H.M. Hwang, Y.W. Grundke-Iqbal, I. Healy-Louie, G. Iqbal, K. |
| shingle_author_2 | Lin, F.H. Lin, R. Wisniewski, H.M. Hwang, Y.W. Grundke-Iqbal, I. Healy-Louie, G. Iqbal, K. |
| shingle_author_3 | Lin, F.H. Lin, R. Wisniewski, H.M. Hwang, Y.W. Grundke-Iqbal, I. Healy-Louie, G. Iqbal, K. |
| shingle_author_4 | Lin, F.H. Lin, R. Wisniewski, H.M. Hwang, Y.W. Grundke-Iqbal, I. Healy-Louie, G. Iqbal, K. |
| shingle_catch_all_1 | Lin, F.H. Lin, R. Wisniewski, H.M. Hwang, Y.W. Grundke-Iqbal, I. Healy-Louie, G. Iqbal, K. Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in alzheimer's brains [abr] ALS; amyotrophic lateral sclerosis [abr] ND2; NADH dehydrogenase (EC 1.6.99.3) subunit 2 [abr] ND4; NADH dehydrogenase (EC 1.6.99.3) subunit 4 [abr] NFT; neurofibrillary tangles [abr] PCR; polymerase chain reaction [abr] PHF; paired helical filaments [abr] SNuPE; single nucleotide primer extension [abr] pfu; plaques forming unit [abr] ALS; amyotrophic lateral sclerosis [abr] ND2; NADH dehydrogenase (EC 1.6.99.3) subunit 2 [abr] ND4; NADH dehydrogenase (EC 1.6.99.3) subunit 4 [abr] NFT; neurofibrillary tangles [abr] PCR; polymerase chain reaction [abr] PHF; paired helical filaments [abr] SNuPE; single nucleotide primer extension [abr] pfu; plaques forming unit 0006-291X 0006291X Elsevier |
| shingle_catch_all_2 | Lin, F.H. Lin, R. Wisniewski, H.M. Hwang, Y.W. Grundke-Iqbal, I. Healy-Louie, G. Iqbal, K. Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in alzheimer's brains [abr] ALS; amyotrophic lateral sclerosis [abr] ND2; NADH dehydrogenase (EC 1.6.99.3) subunit 2 [abr] ND4; NADH dehydrogenase (EC 1.6.99.3) subunit 4 [abr] NFT; neurofibrillary tangles [abr] PCR; polymerase chain reaction [abr] PHF; paired helical filaments [abr] SNuPE; single nucleotide primer extension [abr] pfu; plaques forming unit [abr] ALS; amyotrophic lateral sclerosis [abr] ND2; NADH dehydrogenase (EC 1.6.99.3) subunit 2 [abr] ND4; NADH dehydrogenase (EC 1.6.99.3) subunit 4 [abr] NFT; neurofibrillary tangles [abr] PCR; polymerase chain reaction [abr] PHF; paired helical filaments [abr] SNuPE; single nucleotide primer extension [abr] pfu; plaques forming unit 0006-291X 0006291X Elsevier |
| shingle_catch_all_3 | Lin, F.H. Lin, R. Wisniewski, H.M. Hwang, Y.W. Grundke-Iqbal, I. Healy-Louie, G. Iqbal, K. Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in alzheimer's brains [abr] ALS; amyotrophic lateral sclerosis [abr] ND2; NADH dehydrogenase (EC 1.6.99.3) subunit 2 [abr] ND4; NADH dehydrogenase (EC 1.6.99.3) subunit 4 [abr] NFT; neurofibrillary tangles [abr] PCR; polymerase chain reaction [abr] PHF; paired helical filaments [abr] SNuPE; single nucleotide primer extension [abr] pfu; plaques forming unit [abr] ALS; amyotrophic lateral sclerosis [abr] ND2; NADH dehydrogenase (EC 1.6.99.3) subunit 2 [abr] ND4; NADH dehydrogenase (EC 1.6.99.3) subunit 4 [abr] NFT; neurofibrillary tangles [abr] PCR; polymerase chain reaction [abr] PHF; paired helical filaments [abr] SNuPE; single nucleotide primer extension [abr] pfu; plaques forming unit 0006-291X 0006291X Elsevier |
| shingle_catch_all_4 | Lin, F.H. Lin, R. Wisniewski, H.M. Hwang, Y.W. Grundke-Iqbal, I. Healy-Louie, G. Iqbal, K. Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in alzheimer's brains [abr] ALS; amyotrophic lateral sclerosis [abr] ND2; NADH dehydrogenase (EC 1.6.99.3) subunit 2 [abr] ND4; NADH dehydrogenase (EC 1.6.99.3) subunit 4 [abr] NFT; neurofibrillary tangles [abr] PCR; polymerase chain reaction [abr] PHF; paired helical filaments [abr] SNuPE; single nucleotide primer extension [abr] pfu; plaques forming unit [abr] ALS; amyotrophic lateral sclerosis [abr] ND2; NADH dehydrogenase (EC 1.6.99.3) subunit 2 [abr] ND4; NADH dehydrogenase (EC 1.6.99.3) subunit 4 [abr] NFT; neurofibrillary tangles [abr] PCR; polymerase chain reaction [abr] PHF; paired helical filaments [abr] SNuPE; single nucleotide primer extension [abr] pfu; plaques forming unit 0006-291X 0006291X Elsevier |
| shingle_title_1 | Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in alzheimer's brains |
| shingle_title_2 | Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in alzheimer's brains |
| shingle_title_3 | Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in alzheimer's brains |
| shingle_title_4 | Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in alzheimer's brains |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:45:15.324Z |
| titel | Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in alzheimer's brains |
| titel_suche | Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in alzheimer's brains Point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 (ND2) were detected in 10 of 19 Alzheimer's brains but not in 11 normal brains. The same mutations were also detected in 2 of 6 patients with amyotrophic lateral sclerosis (ALS). However, neurofibrillary tangles and neuritic plaques characteristic of Alzheimer's disease were found histologically in the brain of one ALS patient who was positive of the mutation. The finding suggests that a point mutation in ND2 is a potential risk factor for Alzheimer's disease. |
| topic | W V U |
| uid | nat_lic_papers_NLZ177001844 |