Increased dolichol content in glucocorticoid-sensitive human T-cell leukemia line grown in the presence of dexamethasone
| ISSN: |
0006-291X
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|---|---|
| Keywords: |
[abr] Dex; dexamethasone, 9α fluoro-11β, 17α, 21 ; [abr] HMG CoA; 3-hydroxy-3-methylglutaryl coenzyme A
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| Source: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
|
| Topics: |
Biology
Chemistry and Pharmacology
Physics
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798292227309436928 |
|---|---|
| autor | Dutta, A. Parikh, B. Maben, R. Melnykovych, G. |
| autorsonst | Dutta, A. Parikh, B. Maben, R. Melnykovych, G. |
| book_url | http://dx.doi.org/10.1016/S0006-291X(89)80192-5 |
| datenlieferant | nat_lic_papers |
| fussnote | Two cell lines, derived from human T-cell acute leukemia, one glucocorticoid sensitive (CEM-C7) and the other glucocorticoid resistant (CEM-C1) were grown in the presence of 1 x 10^-^7 M dexamethasone and were analyzed for their dolichol content. After 24 hrs of incubation, dolichols became significantly elevated in the sensitive but not in the resistant line. Lovastatin, the specific inhibitor of cholesterol synthesis did not affect dolichol levels in either of the two cell lines. The results raise the possibility that dolichol accumulation might be involved in the early stages of the glucocorticoid-induced apoptosis (directed cell killing). |
| hauptsatz | hsatz_simple |
| identnr | NLZ176950575 |
| issn | 0006-291X |
| journal_name | Biochemical and Biophysical Research Communications |
| materialart | 1 |
| package_name | Elsevier |
| publikationsort | Amsterdam |
| publisher | Elsevier |
| reference | 158 (1989), S. 163-169 |
| schlagwort | [abr] Dex; dexamethasone, 9α fluoro-11β, 17α, 21 [abr] HMG CoA; 3-hydroxy-3-methylglutaryl coenzyme A |
| search_space | articles |
| shingle_author_1 | Dutta, A. Parikh, B. Maben, R. Melnykovych, G. |
| shingle_author_2 | Dutta, A. Parikh, B. Maben, R. Melnykovych, G. |
| shingle_author_3 | Dutta, A. Parikh, B. Maben, R. Melnykovych, G. |
| shingle_author_4 | Dutta, A. Parikh, B. Maben, R. Melnykovych, G. |
| shingle_catch_all_1 | Dutta, A. Parikh, B. Maben, R. Melnykovych, G. Increased dolichol content in glucocorticoid-sensitive human T-cell leukemia line grown in the presence of dexamethasone [abr] Dex; dexamethasone, 9α fluoro-11β, 17α, 21 [abr] HMG CoA; 3-hydroxy-3-methylglutaryl coenzyme A [abr] Dex; dexamethasone, 9α fluoro-11β, 17α, 21 [abr] HMG CoA; 3-hydroxy-3-methylglutaryl coenzyme A 0006-291X 0006291X Elsevier |
| shingle_catch_all_2 | Dutta, A. Parikh, B. Maben, R. Melnykovych, G. Increased dolichol content in glucocorticoid-sensitive human T-cell leukemia line grown in the presence of dexamethasone [abr] Dex; dexamethasone, 9α fluoro-11β, 17α, 21 [abr] HMG CoA; 3-hydroxy-3-methylglutaryl coenzyme A [abr] Dex; dexamethasone, 9α fluoro-11β, 17α, 21 [abr] HMG CoA; 3-hydroxy-3-methylglutaryl coenzyme A 0006-291X 0006291X Elsevier |
| shingle_catch_all_3 | Dutta, A. Parikh, B. Maben, R. Melnykovych, G. Increased dolichol content in glucocorticoid-sensitive human T-cell leukemia line grown in the presence of dexamethasone [abr] Dex; dexamethasone, 9α fluoro-11β, 17α, 21 [abr] HMG CoA; 3-hydroxy-3-methylglutaryl coenzyme A [abr] Dex; dexamethasone, 9α fluoro-11β, 17α, 21 [abr] HMG CoA; 3-hydroxy-3-methylglutaryl coenzyme A 0006-291X 0006291X Elsevier |
| shingle_catch_all_4 | Dutta, A. Parikh, B. Maben, R. Melnykovych, G. Increased dolichol content in glucocorticoid-sensitive human T-cell leukemia line grown in the presence of dexamethasone [abr] Dex; dexamethasone, 9α fluoro-11β, 17α, 21 [abr] HMG CoA; 3-hydroxy-3-methylglutaryl coenzyme A [abr] Dex; dexamethasone, 9α fluoro-11β, 17α, 21 [abr] HMG CoA; 3-hydroxy-3-methylglutaryl coenzyme A 0006-291X 0006291X Elsevier |
| shingle_title_1 | Increased dolichol content in glucocorticoid-sensitive human T-cell leukemia line grown in the presence of dexamethasone |
| shingle_title_2 | Increased dolichol content in glucocorticoid-sensitive human T-cell leukemia line grown in the presence of dexamethasone |
| shingle_title_3 | Increased dolichol content in glucocorticoid-sensitive human T-cell leukemia line grown in the presence of dexamethasone |
| shingle_title_4 | Increased dolichol content in glucocorticoid-sensitive human T-cell leukemia line grown in the presence of dexamethasone |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| timestamp | 2024-05-06T08:45:10.371Z |
| titel | Increased dolichol content in glucocorticoid-sensitive human T-cell leukemia line grown in the presence of dexamethasone |
| titel_suche | Increased dolichol content in glucocorticoid-sensitive human T-cell leukemia line grown in the presence of dexamethasone Two cell lines, derived from human T-cell acute leukemia, one glucocorticoid sensitive (CEM-C7) and the other glucocorticoid resistant (CEM-C1) were grown in the presence of 1 x 10^-^7 M dexamethasone and were analyzed for their dolichol content. After 24 hrs of incubation, dolichols became significantly elevated in the sensitive but not in the resistant line. Lovastatin, the specific inhibitor of cholesterol synthesis did not affect dolichol levels in either of the two cell lines. The results raise the possibility that dolichol accumulation might be involved in the early stages of the glucocorticoid-induced apoptosis (directed cell killing). |
| topic | W V U |
| uid | nat_lic_papers_NLZ176950575 |